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Database: UniProt
Entry: J9ZD29_LEPFM
LinkDB: J9ZD29_LEPFM
Original site: J9ZD29_LEPFM 
ID   J9ZD29_LEPFM            Unreviewed;       746 AA.
AC   J9ZD29;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   Name=pcrA {ECO:0000313|EMBL:AFS54264.1};
GN   OrderedLocusNames=LFML04_2068 {ECO:0000313|EMBL:AFS54264.1};
OS   Leptospirillum ferriphilum (strain ML-04).
OC   Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC   Leptospirillum.
OX   NCBI_TaxID=1048260 {ECO:0000313|EMBL:AFS54264.1, ECO:0000313|Proteomes:UP000006177};
RN   [1] {ECO:0000313|EMBL:AFS54264.1, ECO:0000313|Proteomes:UP000006177}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ML-04 {ECO:0000313|EMBL:AFS54264.1,
RC   ECO:0000313|Proteomes:UP000006177};
RX   PubMed=22203551; DOI=10.1007/s12275-011-1099-9;
RA   Mi S., Song J., Lin J., Che Y., Zheng H., Lin J.;
RT   "Complete genome of Leptospirillum ferriphilum ML-04 provides insight into
RT   its physiology and environmental adaptation.";
RL   J. Microbiol. 49:890-901(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; CP002919; AFS54264.1; -; Genomic_DNA.
DR   RefSeq; WP_014961768.1; NC_018649.1.
DR   AlphaFoldDB; J9ZD29; -.
DR   STRING; 1048260.LFML04_2068; -.
DR   KEGG; lfi:LFML04_2068; -.
DR   PATRIC; fig|1048260.3.peg.2251; -.
DR   HOGENOM; CLU_004585_5_2_0; -.
DR   OMA; HCANILI; -.
DR   Proteomes; UP000006177; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW   ECO:0000313|EMBL:AFS54264.1};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          4..281
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          282..562
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          621..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         25..32
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   746 AA;  84571 MW;  7E742219D345F9A3 CRC64;
     MTREELNPAQ QEAVSHEGGP LLVLAPAGSG KTRVVIARLL YLLDRYGWSE ERLLVVTFTR
     KAARELLHRI SRLRPSSRPS WVGTFHSVAA RMLRQHAERV DLPREFTIVD GPDQLQMIRD
     LLGRQGLSDK EVDPKKLAGR IGKWKSAGVD PAEAIRTSFG PFRIQAELYA AYQDNLALQK
     ALDFDDLLLT LVRCLEQDPE VRESYQRQFE HILVDEYQDT NPLQERLLRL LSRDRQNVTV
     VGDDDQSIYR FRGAEVGHIL SFPKEYPGAR QVVLTVNYRS TRPIVTAASS MISSALARYR
     KDMVSTGRPG EPVFLKKLDS EWAEARFVAR TIREKVERGA MFRDQVVLFR MNVQAQPFVR
     AFSEAGIPFQ TRGAVQGFFN RREIRDLLAY LRVSANPFDR ISLGRILNIP PRGMGAKARE
     RLDQQAGNPG LSSWELLERL SLDLSGKARE SARAFANDLQ EASRMARGGD GPLSLLQFWL
     SRTGYEKWVS EEEAGEDAPG REENLKELLR MSERFGNGIG ELTDRTPTGV FLEELALSQE
     DPGEPGESPD RVSLLTIHQA KGLEFPHVYL VGAEEDILPM KSREKVDVEE ERRLFYVAMT
     RARDSLVITW CLTRQLFGRT ESPRPSRFLR DIPPEAFQGD RPVFRPETSA PRQTSESFQR
     KFFSPPPLAP SRPGRDFRPV PEKGSPTPTG VLRPEWIGKT VVHPRFGRGR VEEAYGEGGD
     LELSIRFESS GVRRLLERFA NLQVDG
//
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