ID K0BEH0_9ARCH Unreviewed; 754 AA.
AC K0BEH0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Aconitate hydratase {ECO:0000313|EMBL:AFS83425.1};
DE EC=4.2.1.3 {ECO:0000313|EMBL:AFS83425.1};
GN ORFNames=NSED_08165 {ECO:0000313|EMBL:AFS83425.1};
OS Candidatus Nitrosopumilus sediminis.
OC Archaea; Nitrososphaerota; Nitrososphaeria; Nitrosopumilales;
OC Nitrosopumilaceae; Nitrosopumilus.
OX NCBI_TaxID=1229909 {ECO:0000313|EMBL:AFS83425.1, ECO:0000313|Proteomes:UP000006100};
RN [1] {ECO:0000313|EMBL:AFS83425.1, ECO:0000313|Proteomes:UP000006100}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR2 {ECO:0000313|EMBL:AFS83425.1,
RC ECO:0000313|Proteomes:UP000006100};
RX PubMed=23209211; DOI=10.1128/JB.01869-12;
RA Park S.J., Kim J.G., Jung M.Y., Kim S.J., Cha I.T., Ghai R.,
RA Martin-Cuadrado A.B., Rodriguez-Valera F., Rhee S.K.;
RT "Draft Genome Sequence of an Ammonia-Oxidizing Archaeon, "Candidatus
RT Nitrosopumilus sediminis" AR2, from Svalbard in the Arctic Circle.";
RL J. Bacteriol. 194:6948-6949(2012).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
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DR EMBL; CP003843; AFS83425.1; -; Genomic_DNA.
DR RefSeq; WP_014965795.1; NC_018656.1.
DR AlphaFoldDB; K0BEH0; -.
DR STRING; 1229909.NSED_08165; -.
DR GeneID; 13698392; -.
DR KEGG; nir:NSED_08165; -.
DR PATRIC; fig|1229909.8.peg.1796; -.
DR eggNOG; arCOG01697; Archaea.
DR HOGENOM; CLU_006714_2_2_2; -.
DR OrthoDB; 255at2157; -.
DR Proteomes; UP000006100; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 3.40.1060.10; Aconitase, Domain 2; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR015932; Aconitase_dom2.
DR InterPro; IPR006248; Aconitase_mito-like.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR NCBIfam; TIGR01340; aconitase_mito; 1.
DR PANTHER; PTHR43160; ACONITATE HYDRATASE B; 1.
DR PANTHER; PTHR43160:SF4; ACONITATE HYDRATASE B; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF00694; Aconitase_C; 1.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR PROSITE; PS00450; ACONITASE_1; 1.
DR PROSITE; PS01244; ACONITASE_2; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000313|EMBL:AFS83425.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 36..478
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 560..687
FT /note="Aconitase A/isopropylmalate dehydratase small
FT subunit swivel"
FT /evidence="ECO:0000259|Pfam:PF00694"
SQ SEQUENCE 754 AA; 82581 MW; 8FA33EE37D1CB961 CRC64;
MNIDSTPELV SGVYAKLKEN IAKFRNVTGR PLTLTEKILS GHFNEIDDKN YTGGKDYVFL
KPDRVALQDV TGQMVMLQFM QAGLKQAALP TTVHCDHLIR AEVQGDIDMK VSLDENSEVF
KFLQSAAAKY GCGFWKPGAG IIHQVVLENY AFPGGLMIGT DSHTPNAGGL GMVAIGVGGL
DAAETMAGMP WELLYPKRIG VKLTGELNGW TAPKDIILKV AEKLTVSGGT NSIVEYFGPG
TKSISCTGKA TITNMGAEIG ATCSIFPYDE RMETYLKYTN RGDIAELANQ NKESLVADPE
VESNPEKFFD KVIEINLSTL EPHIVGPHTP DLARSISELS DDVKSNDYVD PISVALIGSC
TNSSYEDMSR AASLAEQAKQ KGIKAKIPLL VTPGSEQIRG TIERDGQMDS LKDIGATVLA
NACGPCIGQW NRPELNNDEK NTIVTTFNRN FPGRNDGHRN TLNFIGSPEM IIALSLGGKL
SFNPLVDELT AADGTKFKLE PPKPAPEVPK EGFVRPEGIF VAPPENSDDV EVIIDPNSKR
LQKLEPFTKW DGNDFEELPI MVKAKGKCTT DHISPAGAWL SLRGHLDNLS DNMLLGAVNA
FNDEVGKGKN VLNNKLESFS KIARQYKEKQ MRWVIIGDNN YGEGSSREHA AMTPRFLGCA
AVITKSLARI HETNLKKQGL LALTFNNPDD YEKILEDDRI SLVDLNNLQP GKQVKCIITH
NDGNKEEIML NHSYNQAQIE WFKAGSALNV LRNR
//
