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Database: UniProt
Entry: K0HUI2_9BURK
LinkDB: K0HUI2_9BURK
Original site: K0HUI2_9BURK 
ID   K0HUI2_9BURK            Unreviewed;       723 AA.
AC   K0HUI2;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   08-MAY-2019, entry version 47.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AFU44397.1};
GN   ORFNames=C380_03360 {ECO:0000313|EMBL:AFU44397.1};
OS   Acidovorax sp. KKS102.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Acidovorax.
OX   NCBI_TaxID=358220 {ECO:0000313|EMBL:AFU44397.1, ECO:0000313|Proteomes:UP000006306};
RN   [1] {ECO:0000313|EMBL:AFU44397.1, ECO:0000313|Proteomes:UP000006306}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KKS102 {ECO:0000313|EMBL:AFU44397.1,
RC   ECO:0000313|Proteomes:UP000006306};
RX   PubMed=23209225; DOI=10.1128/JB.01848-12;
RA   Ohtsubo Y., Maruyama F., Mitsui H., Nagata Y., Tsuda M.;
RT   "Complete Genome Sequence of Acidovorax sp. Strain KKS102, a
RT   Polychlorinated-Biphenyl Degrader.";
RL   J. Bacteriol. 194:6970-6971(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
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DR   EMBL; CP003872; AFU44397.1; -; Genomic_DNA.
DR   RefSeq; WP_015012479.1; NC_018708.1.
DR   STRING; 358220.C380_03360; -.
DR   EnsemblBacteria; AFU44397; AFU44397; C380_03360.
DR   KEGG; ack:C380_03360; -.
DR   PATRIC; fig|358220.3.peg.684; -.
DR   KO; K01782; -.
DR   OrthoDB; 977512at2; -.
DR   BioCyc; ASP358220:G1HB5-673-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000006306; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006306};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN      326    504       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      507    607       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   723 AA;  77629 MW;  0B9C1FBAEE85EE41 CRC64;
     MQTIRYELIP AQGTDGEVVV ITFDETNSPV NTMCRQWQQE LGEVTAQVLG DRERLGPALK
     GIVLASAKTS FFAGADLKAT MRLTPADAPN AFGEIERMKK HFRTLETLGI PVVACLNGAA
     LGGGWEVALV AHYRIAVADP KIQFGLPEVT LGLMPGATGV TKMTRLLGLM GAQPYILEGK
     LFNPAEALEL QLVHELVATR EQLLPAALAH IATHPHAVHP WDDKNYKMPG GTPANPKIAG
     ALTVAPAMLK KTTRGRYPAP EAALAAMVEG AMVDYDTALR IESRYLARLM TGPVARNMIN
     TFFFDMNAIK SGKSRPGSAP RYKPQKVGIL GAGMMGAGIA WAQASRGIAT VLKDVSTEKA
     EAGKAYSAKL TQARVDKGRM TAEAQQALLA RITPTASAAD LAGCDLIIEA VFENRDLKAK
     VTQEAEPQLA PGGFFASNTS TLPISGLATA SSRPEKFVGI HFFSPVDKMK LVEIIRGKQT
     DDETVARAFD YVQALGKVPI VVNDSRGFYT SRTFGTFVME GAAMLGEGIP AAAIENAAMQ
     AGLPVGPLAV LDETALTLSV HVLDQTRADY AAEGKTYTAT PGELLVERMV KELKRPGRAG
     GGGFYDYPAG AKKHLWPELK PLFEKPGVEW SVQEIQDRLL YRQAIETARC LAEGVLTSVH
     DANIGSIFGI GFPAWTGGAM QFVYGTGMET FLKRADELAA KYGTGFSLDA KARETVERYR
     PSY
//
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