ID K0HWW6_9BURK Unreviewed; 291 AA.
AC K0HWW6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=6-phosphogluconate dehydrogenase {ECO:0000313|EMBL:AFU47433.1};
GN ORFNames=C380_18695 {ECO:0000313|EMBL:AFU47433.1};
OS Acidovorax sp. KKS102.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Acidovorax.
OX NCBI_TaxID=358220 {ECO:0000313|EMBL:AFU47433.1, ECO:0000313|Proteomes:UP000006306};
RN [1] {ECO:0000313|EMBL:AFU47433.1, ECO:0000313|Proteomes:UP000006306}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KKS102 {ECO:0000313|EMBL:AFU47433.1,
RC ECO:0000313|Proteomes:UP000006306};
RX PubMed=23209225; DOI=10.1128/JB.01848-12;
RA Ohtsubo Y., Maruyama F., Mitsui H., Nagata Y., Tsuda M.;
RT "Complete Genome Sequence of Acidovorax sp. Strain KKS102, a
RT Polychlorinated-Biphenyl Degrader.";
RL J. Bacteriol. 194:6970-6971(2012).
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DR EMBL; CP003872; AFU47433.1; -; Genomic_DNA.
DR RefSeq; WP_015015396.1; NC_018708.1.
DR AlphaFoldDB; K0HWW6; -.
DR STRING; 358220.C380_18695; -.
DR KEGG; ack:C380_18695; -.
DR PATRIC; fig|358220.3.peg.3810; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_0_2_4; -.
DR OrthoDB; 9777604at2; -.
DR Proteomes; UP000006306; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 2..160
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 168..284
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 291 AA; 30733 MW; CE1EA7AE4F3D225B CRC64;
MQIGFIGLGV MGLPMALNLA RAGTPLWVWN RSPEKCELLR AAGAQVGATP AEICAQAQVI
ILMLANEPAM DEALQRGTPG FATQVRDRII VHMGTTSPEY SKALEQDILA AGGRYVEAPV
SGSRKPAEAG QLVGMLAGDP ASVQAVQPLL APMCRTTFVC GAVPSALLMK LSVNLFLITM
VTGLCEAAHF ADRNGLDMEL FRSVLDAGPM ASSVSQMKLA KLVARDFEVQ AAIHDVLKNN
QLVAQAARSA RLASPLLDAC HALFAQTADM GLGQEDMVAV VRALEARTEA L
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