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Database: UniProt
Entry: K0IE04_NITGG
LinkDB: K0IE04_NITGG
Original site: K0IE04_NITGG 
ID   K0IE04_NITGG            Unreviewed;       350 AA.
AC   K0IE04;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   SubName: Full=NAD-dependent alcohol dehydrogenase {ECO:0000313|EMBL:AFU59601.1};
DE            EC=1.1.1.1 {ECO:0000313|EMBL:AFU59601.1};
GN   Name=adh4 {ECO:0000313|EMBL:AFU59601.1};
GN   OrderedLocusNames=Ngar_c26800 {ECO:0000313|EMBL:AFU59601.1};
OS   Nitrososphaera gargensis (strain Ga9.2).
OC   Archaea; Nitrososphaerota; Nitrososphaeria; Nitrososphaerales;
OC   Nitrososphaeraceae; Nitrososphaera.
OX   NCBI_TaxID=1237085 {ECO:0000313|EMBL:AFU59601.1, ECO:0000313|Proteomes:UP000008037};
RN   [1] {ECO:0000313|EMBL:AFU59601.1, ECO:0000313|Proteomes:UP000008037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ga9.2 {ECO:0000313|Proteomes:UP000008037};
RX   PubMed=23057602; DOI=10.1111/j.1462-2920.2012.02893.x;
RA   Spang A., Poehlein A., Offre P., Zumbragel S., Haider S., Rychlik N.,
RA   Nowka B., Schmeisser C., Lebedeva E.V., Rattei T., Bohm C., Schmid M.,
RA   Galushko A., Hatzenpichler R., Weinmaier T., Daniel R., Schleper C.,
RA   Spieck E., Streit W., Wagner M.;
RT   "The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis:
RT   insights into metabolic versatility and environmental adaptations.";
RL   Environ. Microbiol. 14:3122-45(2012).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; CP002408; AFU59601.1; -; Genomic_DNA.
DR   AlphaFoldDB; K0IE04; -.
DR   STRING; 1237085.Ngar_c26800; -.
DR   KEGG; nga:Ngar_c26800; -.
DR   PATRIC; fig|1237085.11.peg.2655; -.
DR   HOGENOM; CLU_026673_11_2_2; -.
DR   InParanoid; K0IE04; -.
DR   OMA; CERQTQP; -.
DR   OrthoDB; 73567at2157; -.
DR   Proteomes; UP000008037; Chromosome.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08240; 6_hydroxyhexanoate_dh_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43401:SF4; ALCOHOL DEHYDROGENASE GROES DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR43401; L-THREONINE 3-DEHYDROGENASE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:AFU59601.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008037};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          8..348
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   350 AA;  37108 MW;  DC72E19607A41354 CRC64;
     MKAARIIKTK EPLEIKDVGV PKPKNDQVLV RVESAGVCHS DLHLWEGGYA GPQGVFMKVE
     DRGVKFPLTP GHEIAGTIEE MGESVTGFSK GEKVLVYPWI GEGTCPACRV GEENVCDAPR
     SLGIYQDGGY SEMVLVPSHK YLVKLQGLDP NSAASLACSG LTAYTAVKKA GAQPGDTLVI
     VGAGGLGLMA VQIAKSITNA RIAIVDIDDK KLAEAKRLGA HEVINSGASD SVKGVKDITN
     NFGAEAVIDF VNNAKTAPNS LNMLRKRGRL VMVGLFGGSL ELNLPLIPLR AFTLTGAYTG
     KFADLVELVA LARMDKIQSV VSRKFTLDQA NSALEELKSG KIIGRAVINP
//
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