ID   K0IYD9_AMPXN            Unreviewed;       474 AA.
AC   K0IYD9;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=DNA polymerase I {ECO:0000313|EMBL:BAM47525.1};
GN   OrderedLocusNames=AXY_13930 {ECO:0000313|EMBL:BAM47525.1};
OS   Amphibacillus xylanus (strain ATCC 51415 / DSM 6626 / JCM 7361 / LMG 17667
OS   / NBRC 15112 / Ep01).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Amphibacillus.
OX   NCBI_TaxID=698758 {ECO:0000313|EMBL:BAM47525.1, ECO:0000313|Proteomes:UP000006294};
RN   [1] {ECO:0000313|EMBL:BAM47525.1, ECO:0000313|Proteomes:UP000006294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51415 / DSM 6626 / JCM 7361 / LMG 17667 / NBRC 15112 /
RC   Ep01 {ECO:0000313|Proteomes:UP000006294};
RA   Nakazawa H., Katano Y., Nakamura S., Sasagawa M., Fukada J., Arai T.,
RA   Sasakura N., Mochizuki D., Hosoyama A., Harada K., Horikawa H., Kato Y.,
RA   Harada T., Sasaki K., Sekiguchi M., Hodoyama M., Nishiko R., Narita H.,
RA   Hanamaki A., Hata C., Konno Y., Niimura Y., Yamazaki S., Fujita N.;
RT   "Whole genome sequence of Amphibacillus xylinus NBRC 15112.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705}.
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DR   EMBL; AP012050; BAM47525.1; -; Genomic_DNA.
DR   AlphaFoldDB; K0IYD9; -.
DR   STRING; 698758.AXY_13930; -.
DR   KEGG; axl:AXY_13930; -.
DR   PATRIC; fig|698758.3.peg.1389; -.
DR   eggNOG; COG0749; Bacteria.
DR   HOGENOM; CLU_012044_3_2_9; -.
DR   Proteomes; UP000006294; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006294}.
FT   DOMAIN          268..474
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   474 AA;  53886 MW;  F285F0A99AB97BE8 CRC64;
     MVWSAYMGLP LSLESVGAVL GLEKQKLTEG KDLIRYFCIP CKPTKANGGR TRNFPKHDRD
     RWQRFKEYNA RDVETEMLIQ EKLFKFPVPD FIWKEYEMDQ IINDRGIAID MDFVKQAVYI
     DGVSSENLMT VMQDITKLEN PNSVQQMKGW LLENGIETES LGKKAVAKLL ESAKEPYKTV
     LELRQKLAKS SIKKYAAMEN AVCGDGRARG MFQFYGANRT GRFSGRLIQL QNLPQNHMKD
     LGEARSLVRS KNTEALELLY EDVPDTLSQL IRTSFIPKKD KKFIVADFSA IEARVIAWLA
     NEKWRIDVFA DGGDIYCASA SQMFNIPVEK NGINGHLRQK GKIAELALGY GGSIGALDMG
     LKEEELQPLV YAWRQSNPKI TKLWWDVDRA AKNCVKEKTP TETHGIKFIY QSGMLFIVLP
     SGRKLAYVKP RMGENKFGGE AVTYEGVGGT KKWERIESYG PKKVTILWPM SMMK
//