ID K0JPJ5_SACES Unreviewed; 340 AA.
AC K0JPJ5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081,
GN ECO:0000313|EMBL:CCH28810.1};
GN OrderedLocusNames=BN6_14860 {ECO:0000313|EMBL:CCH28810.1};
OS Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC
OS 15066 / NRRL 15764).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH28810.1, ECO:0000313|Proteomes:UP000006281};
RN [1] {ECO:0000313|EMBL:CCH28810.1, ECO:0000313|Proteomes:UP000006281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC {ECO:0000313|Proteomes:UP000006281};
RX PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT comparison to the other completely sequenced Pseudonocardiaceae.";
RL BMC Genomics 13:465-465(2012).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; HE804045; CCH28810.1; -; Genomic_DNA.
DR RefSeq; WP_015098923.1; NC_019673.1.
DR AlphaFoldDB; K0JPJ5; -.
DR STRING; 1179773.BN6_14860; -.
DR KEGG; sesp:BN6_14860; -.
DR PATRIC; fig|1179773.3.peg.1490; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_2_0_11; -.
DR OrthoDB; 9783139at2; -.
DR BioCyc; SESP1179773:BN6_RS07295-MONOMER; -.
DR Proteomes; UP000006281; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR001034; DeoR_HTH.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF08220; HTH_DeoR; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006281};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 16..63
FT /note="HTH deoR-type"
FT /evidence="ECO:0000259|Pfam:PF08220"
FT DOMAIN 104..323
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 340 AA; 37093 MW; 5953862453693963 CRC64;
MNTDERRFEV LRAIVADYVS NQEPVGSKAL VERHNLGVSS ATVRNDMAAL EEDGYITQPH
TSAGRVPTDK GYRLFVDRLS EVKPLSSPER RAIRSFLEGA YDLDDVLRRS VRLLAQLTRQ
VAVVQYPTLS RSTVRHLEVL AITPARLMLV LITDTGRVDQ RSVDLGDVIT EENVARMRAM
LNSAMVGKRL SDASAEVAEL PDRAPAELRD VVLRVSTVLI ESLVEHPEER LVLGGTANLT
RNVADFPGSL RQVLEALEEQ VVVLKLLAAS RDPGTVLVHI GEENEAAEMR STSVVSIGYG
SRDNLLGGMG VVGPTRMDYP GTMAAVLAVA SYVGDILTAR
//
