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Database: UniProt
Entry: K0JRN5_SACES
LinkDB: K0JRN5_SACES
Original site: K0JRN5_SACES 
ID   K0JRN5_SACES            Unreviewed;       311 AA.
AC   K0JRN5;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   10-APR-2019, entry version 32.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   OrderedLocusNames=BN6_01360 {ECO:0000313|EMBL:CCH27469.1};
OS   Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 /
OS   NBRC 15066 / NRRL 15764).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharothrix.
OX   NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH27469.1, ECO:0000313|Proteomes:UP000006281};
RN   [1] {ECO:0000313|EMBL:CCH27469.1, ECO:0000313|Proteomes:UP000006281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC   {ECO:0000313|Proteomes:UP000006281};
RX   PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA   Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA   Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT   "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT   comparison to the other completely sequenced Pseudonocardiaceae.";
RL   BMC Genomics 13:465-465(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; HE804045; CCH27469.1; -; Genomic_DNA.
DR   STRING; 1179773.BN6_01360; -.
DR   EnsemblBacteria; CCH27469; CCH27469; BN6_01360.
DR   KEGG; sesp:BN6_01360; -.
DR   PATRIC; fig|1179773.3.peg.135; -.
DR   KO; K04518; -.
DR   OMA; REVMSAC; -.
DR   BioCyc; SESP1179773:BN6_RS00665-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000006281; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006281};
KW   Lyase {ECO:0000256|RuleBase:RU361254, ECO:0000313|EMBL:CCH27469.1};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006281}.
FT   DOMAIN        1    179       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      193    270       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        172    172       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   311 AA;  32623 MW;  71CABA3F006DD9C5 CRC64;
     MLAYFGPQGT FTEQAARAFS AADPAHDDLV PFDTVPAALA AARRGEVDAA CVPVENSVEG
     AVPATMDALT EGDPLVAVAE TVLDVRFSVL VRPGAGEPKT IASHPHALAQ VRHWIAENLP
     TATAVATTST AAAARAVLAG EFDAAVSAPV AVRHYPLEVL ATDVADVRDA KTRFLLLRRP
     GPLPRPTGHD RTSVVVTATD RIGALSDLLA ELALRRINLT RIESRPTKGR LGEYRFYIDL
     DGHAAEPGVG DALAALRRHC PDTRFLGSYP KAEPVLRAEA GARAEPGGSP AADEFVAAAE
     WVASLREGLG A
//
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