ID K0JUG2_SACES Unreviewed; 1300 AA.
AC K0JUG2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=ATP-dependent RNA helicase HrpA {ECO:0000313|EMBL:CCH31485.1};
DE EC=3.6.4.13 {ECO:0000313|EMBL:CCH31485.1};
GN Name=hrpA {ECO:0000313|EMBL:CCH31485.1};
GN OrderedLocusNames=BN6_41980 {ECO:0000313|EMBL:CCH31485.1};
OS Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC
OS 15066 / NRRL 15764).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH31485.1, ECO:0000313|Proteomes:UP000006281};
RN [1] {ECO:0000313|EMBL:CCH31485.1, ECO:0000313|Proteomes:UP000006281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC {ECO:0000313|Proteomes:UP000006281};
RX PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT comparison to the other completely sequenced Pseudonocardiaceae.";
RL BMC Genomics 13:465-465(2012).
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DR EMBL; HE804045; CCH31485.1; -; Genomic_DNA.
DR RefSeq; WP_015101597.1; NC_019673.1.
DR STRING; 1179773.BN6_41980; -.
DR KEGG; sesp:BN6_41980; -.
DR PATRIC; fig|1179773.3.peg.4202; -.
DR eggNOG; COG1643; Bacteria.
DR HOGENOM; CLU_001832_3_3_11; -.
DR OrthoDB; 9805617at2; -.
DR BioCyc; SESP1179773:BN6_RS20320-MONOMER; -.
DR Proteomes; UP000006281; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17989; DEXHc_HrpA; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR024590; HrpA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010222; RNA_helicase_HrpA.
DR NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11898; DUF3418; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:CCH31485.1};
KW Hydrolase {ECO:0000313|EMBL:CCH31485.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006281}.
FT DOMAIN 84..247
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 277..444
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 525..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1300 AA; 145705 MW; D60A5574FDE166E7 CRC64;
MNTTAHSDLH RRLSDLMSGD QRRLGRRLDG ARRVRDEQAR AAVHAEIAAE IEQAELRVAL
RRAAVPKITY PGELPVSARK DDIAALIRDH QVVIVAGETG SGKTTQIPKI CLELGRGVLG
QIGHTQPRRL AARTVAERVA QELGTQLGQA VGYKVRFTDQ SGDETLVKLM TDGILLAEIQ
TDRTLSRYDT IIIDEAHERS LNVDFLLGYL KQLLPRRPDL KVVITSATID PERFSRHFAD
APIIEVSGRT YPVEVRYRPV VDPDDPDADP DRDQTQAVCD AVRELQAEGP GDVLVFLSGE
REIRDTADAL AALGLPHTEI LPLYARLSFG EQHKVFQSHR GRRVVLATNV AETSLTVPGI
KYVVDPGTAR ISRYSNRLKV QRLPIEPISQ ASANQRKGRC GRVSAGICVR LYSEDSFDAR
PEFTDPEILR TNLASVILQM TAIGLGDIAA FPFIDPPEAR NINDGVQLLH ELGAIVPAEQ
KLTPLGRKLA QLPVDPRLAR MVIEADRNGC VREVMVIASA LSIQDPRERP SDKQQAADEQ
HNRFKDPDSD FVAYLNLWQY LREQQKALSS NQFRRLCRAE FLNYLRVREW QDIYSQLRQV
AKTLGVHVNE QPAEPRAVHL SLLSGLLSHI GLKDVVKRDP GKRQSSEYLG ARNAKFAIFP
GSALFRKPPQ WVMAAELVET SRLWGRIVAR IEPEWAEGLA EHLVKRSYSE PHWEAKRGAV
MAMEKVTLYG VPIVGARKVN YGQIDPGLCR ELFIRHALVQ GEWTTHHKFF HHNRALLDEV
AELENRARRR DIVVDDDTLY EFYDQRVGED VVSARHFDTW WKKTRHTQPD LLTFDKQMLV
NDRAQVTPEA YPDELTRGGV ALPLTYRFEP GTAVDGVTVR LPLPALTTVP DDALSWQVPG
LRTELVVALI RSLPKPVRRN FVPVPDVAAA ALSRIDADEP LLPALERELR ALTGVVVPRE
EWQLDQVPEH LKLTFQVVDE NNRELAQGKD LAALKQQLRG QLRETLAAAA SNLTRTGLTT
WDLDELPKTV QRRQSGIVVT AYPALVDKGD SVAVEILDTP GRQAAAMRRG TRRLLLLAVP
SPVKLLQRGL TNAEKLTLTR NPHGGVAALL ADCISAAVDH LVTSAGGPAW NAKGFTRLTE
YVRKYLGETV FDVVREVRNV LDAAQEVELR LAGVKGAVYD ESVADVRAQL KGLVHNGFVT
EAGAARLSDL HRYLQGIARR LEKLPENVRR DQDWMDRVHQ VHAEYRDLKA RLPADEPHPE
LDEVRWMIEE LRLSYFAQTI PTRYTVSDKR VFKALDAVPR
//
