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Database: UniProt
Entry: K0JWI9_SACES
LinkDB: K0JWI9_SACES
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ID   K0JWI9_SACES            Unreviewed;       541 AA.
AC   K0JWI9;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   10-APR-2019, entry version 40.
DE   SubName: Full=Multi-sensor signal transduction histidine kinase {ECO:0000313|EMBL:CCH32200.1};
GN   OrderedLocusNames=BN6_49300 {ECO:0000313|EMBL:CCH32200.1};
OS   Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 /
OS   NBRC 15066 / NRRL 15764).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharothrix.
OX   NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH32200.1, ECO:0000313|Proteomes:UP000006281};
RN   [1] {ECO:0000313|EMBL:CCH32200.1, ECO:0000313|Proteomes:UP000006281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC   {ECO:0000313|Proteomes:UP000006281};
RX   PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA   Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA   Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT   "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT   comparison to the other completely sequenced Pseudonocardiaceae.";
RL   BMC Genomics 13:465-465(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; HE804045; CCH32200.1; -; Genomic_DNA.
DR   STRING; 1179773.BN6_49300; -.
DR   EnsemblBacteria; CCH32200; CCH32200; BN6_49300.
DR   KEGG; sesp:BN6_49300; -.
DR   PATRIC; fig|1179773.3.peg.4946; -.
DR   OMA; SQTIIQA; -.
DR   Proteomes; UP000006281; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR007891; CHASE3.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF05227; CHASE3; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006281};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:CCH32200.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006281};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     49     72       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    218    242       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      242    294       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      323    537       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   541 AA;  57733 MW;  7493F5C3AF0A1546 CRC64;
     MAGVLLSWPR SSWRRAVDAV ASWSGGAVRS GSQSGTDNGP AGGRSLRRWS VLISAVLVVI
     LLGAFAVVLS AIGDLSRARS RLLDVVGPAV VSAQQWGSDL VDQETGVRGF ILSRDEAFLG
     PYADGLIGQE VARAAIVAMG SPEVDAGLAA VDAAVATWRD GYAEPAIDAV RAGTDVPGDS
     AGKRQFDAVR AALSVLRDEM ADQRADGRTA LNDAATRMAV TCIIALGVVL IAVCACVVAV
     HMHVVRPLST LRGQVGRVSS GEFGHTVAAT GPQELLELGH GVDIMRRRIV DELDHARDRN
     TALDAATEDL RRSNAELEQF AYVASHDLQE PLRKIASFCQ LLEQRYGDRL DDRATQYIAF
     AVDGAKRMQV LINDLLAFSR VGRNDDKKVV VAAADLVDAA RHNLAEALDS SGARVEVGDL
     PAVRAVPGLV TAVFQNLIGN AVKFRAAQTP VVRVDAEPGE DDTWVFSVSD NGIGIEQRYA
     ERVFVIFQRL HPKDRYPGTG IGLALCRKIV EFHGGRIWLD TDVTGGTTVR FTLPKAHATV
     G
//
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