ID K0K0L1_SACES Unreviewed; 6706 AA.
AC K0K0L1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:CCH31896.1};
GN Name=pks8-2 {ECO:0000313|EMBL:CCH31896.1};
GN OrderedLocusNames=BN6_46170 {ECO:0000313|EMBL:CCH31896.1};
OS Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC
OS 15066 / NRRL 15764).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH31896.1, ECO:0000313|Proteomes:UP000006281};
RN [1] {ECO:0000313|EMBL:CCH31896.1, ECO:0000313|Proteomes:UP000006281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC {ECO:0000313|Proteomes:UP000006281};
RX PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT comparison to the other completely sequenced Pseudonocardiaceae.";
RL BMC Genomics 13:465-465(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; HE804045; CCH31896.1; -; Genomic_DNA.
DR STRING; 1179773.BN6_46170; -.
DR KEGG; sesp:BN6_46170; -.
DR PATRIC; fig|1179773.3.peg.4626; -.
DR eggNOG; COG0300; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG2021; Bacteria.
DR eggNOG; COG2226; Bacteria.
DR eggNOG; COG2898; Bacteria.
DR eggNOG; COG3033; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000035_0_0_11; -.
DR BioCyc; SESP1179773:BN6_RS22350-MONOMER; -.
DR Proteomes; UP000006281; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd06558; crotonase-like; 1.
DR CDD; cd08953; KR_2_SDR_x; 3.
DR CDD; cd00833; PKS; 4.
DR Gene3D; 1.10.1240.100; -; 3.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR024320; LPG_synthase_C.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR Pfam; PF00378; ECH_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 4.
DR Pfam; PF00109; ketoacyl-synt; 4.
DR Pfam; PF02801; Ketoacyl-synt_C; 4.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF09924; LPG_synthase_C; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 5.
DR Pfam; PF14765; PS-DH; 3.
DR SMART; SM00826; PKS_DH; 3.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 4.
DR SMART; SM00823; PKS_PP; 6.
DR SMART; SM01294; PKS_PP_betabranch; 5.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 5.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00606; KS3_1; 4.
DR PROSITE; PS52004; KS3_2; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006281};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 295..372
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 810..1227
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1754..1831
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1940..2343
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3438..3511
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3561..3976
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4717..4794
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4836..5246
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5436..5513
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1842..1912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5966..6018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1848..1863
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5968..5999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6706 AA; 704724 MW; E713029AE6367F2A CRC64;
MTDHPADRKE DAMAGFECRM VLTHGDFVME NHRLHGVSVM PGVVFFDLVY RAAVAAGWDR
SRLCVRDTVL AEAIVTTEGY DREILLTVGD EGAAGRPFTV RSRWLRAGEP VSGWHDNAHG
LVCLTDEPLP APLDPAAVRA TATGRDDVAT LYRRAVREGI EHGAPMKCRG ALHLGGGRLL
AELTREVSDP AHEFHLHPAS LDATTLAGFG QLAMPTDDPF VPMFVRELRA PEPLPETCLV
HVAAPERLAP SGDVVTTDYT VHDVDGRFLA SFTGLTCKRI REPGLVHRLL DEVARPAGDL
AGQLRALVAD VLGRPVDQVA TGTGFYDLGL DSVALLGLTG RLEDLVGEQL YPTLLFEHST
IDALAAHLSA NHVIKPSDGS TLSFVDEWVP VAGEGAHHGD VAVVADAPVP GLGSAVATAA
GLRDLPEIPG AVVVVSDDPA AALWSAASAL VDAGPRDLLV VTAAPLTPER AGTGALARTV
SAEVPGLRCR FVHVDRPEDI ARAARAELAC DVEPEVRYRA GTRHVRRWRE VTLDHAARPL
RDEGVYLITG GSGGLARLLA EDLTRRHRAR IGLLSRTAPD PGLVEALERA GGQVHVVTAD
VTDADQVRRA VDAVRARFGR IDGVFHCAGI RRDGLFFRGT PADLAAVAAP KVDGLRHLDA
ATAQDGLDFL AVFSSASASI ANLGQAAYAY ANACTEHVER AGRTVVIGWP LWADGGMAVT
DDVVRRSRET TGRIPLPARE GLAVLHGVLA APHRSLVVLH GEPDRIRTLL PAATGPAPTP
VEPTPVPVAE PVLVAAQVAV RENVAVTGDE DAIAVIGVAG RYPGARDVDE FWRNLAAGRD
CVTEVPADRW DHDALFDPAK GVPGRTYGKW GGFLDGVDLF APEFFGISRR DAERMDPQER
LFLTTCLRTL ENAGHPPESL AGEVVGVYAG VMWNHYQLVQ GAEDGVAPHA MHCSIANRVS
HTFDLTGPSL AVDTACSSSL TAVHLAVESI RRGECTMALA GGVNVTVHPQ KYLQLAQGQW
LSVDGRCRAF GRDGTGYVPG EGVGAVLLKR LDRALADGDH VHGVIRATAL NHTGRTAGAT
VPSPGSQAAL IRRALDTAGW DPSSVGYVEA HGTGTSLGDP IEVEGLRQAF AGTPLPAGSC
AIGSVKSSVG HLEGAAGVAG LTKVLLQLRH RALAPSLHAE ETNPHIDFAA TPFRVQRALE
PWQGPVLRAG VSAFGAGGTN AHVLVEEFVP EPPPTTAGPA LVVLSARNAE ELRAYATVLA
GGLPSGSAVE AVAALLGVGA SEVDGSASLG DLGLDVSDVV ELVGAGALAG ITGDVPVSAL
PVDGPIADIA YTTQVGRTAM PVRLAVVASG SAALRVALEK FGRGEESPDV VLDGSTAAGD
PVALFRAGRL LDVARHWVGG GAVPWAECHR GEPRRRVPLP GYPLVEERCW IGAWAASKSP
RLVAPVPEVP VVGVPVVELP VVELPDAEVA VEPTADDGPE LEFRVLEHGI ALVVMRSPMF
TPGLLDGLKA VFGEIEQRDD VRAVVVTGSG TVFSMGGTPE ALRTLAEGAG TFTDASFIYD
GMLKCTRPVV VAASGHASGG GLAFACYGDV VVLSEESVYS ANFAKYGFTP GMGATYVLEQ
RFGAALAKEM LLTGRSLTGG ELLRRGVNVT VLPRAEVLPT ALDLARSMAD RPAAVIRVLK
DELAGRVLRD LPEIIASEVR MHRQVLGEDS AAMVREHFAK VDGFRATGDH EPAVETPEVD
GSGVDGSGVD ESGVDESGVG SAIREILGAL LYLEPDEIGA SRSFSDLGLD SIGAVELVRD
LNRRFGTELD SVAVYDHPTL PDLVGAVLTA AGEKAALRAQ ATAPLPVAPQ PRVEPPVSAD
PPRRPAPSAL TLTVPAVHAT LPAERSGPPD LLISLTPRED SPPRASARTP AVPKPAVPTL
AVAVPAVAVP DAVASGSGEA VPIAVIGMAG RFPDAPDLDA FWRNLVAGVS SIREVPRSRW
DLSSLYDPDP SRTDTTRSRW AALLDDVDAF DAGLFRVSPL EAEAMDPQQR LFLEQAWAAL
EDAGHAGRPL RCGVFVGCAA GDYSRLLDAA GVGTTSEAFL GTASSILPAR IAYLLDLTGP
TMAIDTACSS SLTAVHLACE SIRSGDCDTA LAGGVAVMCT PRMQVWTSQT GMLSPAGRCL
PFDESADGIV LGEGVGAVLL KRLDRALADG DHVHGVILAS GVNGDGRTNG ITAPSATSQA
ALLREVHARA GAAVSYVEAH GTGTHLGDPI EVKALRQVVA PDCALGSVKA NIGHTTMSAG
IAGVLKVLLS LRHRQLPPTP GVRDPIPGLP VVRELTPWSG EHLAAGVSSF GFSGTNCHVV
VGEAPTRPDC DVRGPAVVPV SARTAEALRA RLDRLAAHLK TSGVALHDVA TTLALGRAHL
TARVAFVADD IADLVRQLEH GTPRDISRDT SANHDLARRW AAGEDVDWEP VSRGRRVPLP
AYPFARDRFW VGDVRVDPGD PVVADHVVDG VPTLPGALFL RLATGAAPSV AAVTWLKPVR
VTGPVVLGLA TAGRVELTSG DQVHAVADPR PAPAAEPPLD LAAVEARCPR HVPGDALYAA
FDRVGLRYGP TFRVLSGVAV GDGEALATLH ARAGDDVQVL DGAMQAIAAL LTEEPRPLLP
FAIDSAHVDR DLPAAARVHV TRRSAHRFDV VLTDLAGVVR ARLDGVALRP AAERTGLLHV
PAWRPAATPP VRPTGRVAVV HTAADAALAG ALRPDLSVPL GELPEGRFDS VFVLARPDDP
TSPAEDDRSV LHAFRLVRHL VETGAGRGPL ALTFVVAGTQ AVDGEPVHPH AAGLVGLANA
IAAEYPEWSV TCVDVGEGDP AGYADAVRRE HGEDRLVALR GDRRLVRVLE PAPEPIGSPL
REGGVYVLLG GAGGIGVEVT RHLVQTRNAR VAWLGRSVED TRIGALAAEF GDNVRYFTAD
AGDARAVRGA VEEVRRVFGP VNGAFHSAIT LRDRSLATMT EDDLLAVLRP KTAGLAAFAA
ALRDEPLDFL AVFSSAMAFV PAPGQGNYAA ATAFEDSYAL ALHHAGVPVK LVNWGFWGTV
GIVARADYIA RFAALGIESI EPAEGVTALE HVLAGDHPQV AVLKGTPDGL ALLGVRSPQT
EPQPEDDLAR SRAAFAALDG LARDLLRAAD VPAGDTPLHR AVAAAATAPV AGLSAADVLA
LHPDLTPHVE LLNRCTEGLP GVLDGRTPPT EVLFPGGSTD LVGAVYQGQR AADFYHRLMA
DELARAVGRT DAPRVLEIGA GTGAGTAFAL PAAGGAHYDY TDVSTAFLRS GEEEFGARFP
NAAFRVFDVE ADPVAQGFTP GTYDVVLATN VLHATRDVVQ VLRHARALLR PGGVLLVNEV
TRTSDFLTAT FGLLPGWWRF ADAHRRLPHS PLLSPAGWRS ALGEAGLSMR VLGMPGCADD
EQEQCVLVAT AGAPPSGAAV RDYVRRVFAE VLKFRPADLD DTLTFENFGV DSLVSQRIVR
RFEADLGDLP ATLLFEHLTI GHLAAHLATE HAAALAAVLT PAPATVAAPP ATPVPAVTRV
VTHETVAREA VARDDGKRDD GERIAVVGLA GRYPGARDLD EFWGNLVAGV ASITEVPADR
WDWREHFDPQ KGKPQHTYGR WGGFLADVDR FDPAFFGILP KDAAAMDPQE RLFLETSWLL
LEGTGYLGAE KVRDTGVFVG TMYGSYGRIA AATGWPRGRF TDGHSAYWSI ANRVSYALDL
TGPSFAVDSA CSSSLTAVHL ACESIRRGEC EMAIAGGVNL VLHPAHLIAL SSMTMLARDG
ACKVFDERAD GFVPGEGVGA VLLKPLAAAL RDGDRIRAVI EGGAVNAGGK TAGYTVPNPA
AQAELVVRAL AAAGAEPGSV GYVEAHGTGT ALGDPIEITG LAKALGDDGR CAVGSVKANI
GHLEGAAGIA GLTKVVLQLE HGTIAPCAAL DTVNPRIDLP AGFSLPTAAT PWPAPRRAGV
SSFGAGGANA HLVLSGHETP ERPGVDDTGR HAVLLSARTP AELDALASAV ADHVERHAPG
LASLAWTTQV GRAELAHRLA VVVSDPAELP ARLRAGDVRR GTAGDDFPGR DLVTADAVAD
LVTANDIDRL AELWTHGVAV DWRRTWPVRP DRVPLPPYPF TRQRLWLPEP DDRPWLTAHR
VAGRRVLPGA AALEPVCAEL GTSFTLHDVR WPEPLHVDSR PEPRADLADG TFTVTSGPIT
VAAGRHTAAR PLTEVLDLTG LRARCATEVE PADLYAGLRA GGLDHGERMR VLREVRVGDG
EVLVRIEADH RILVLDGAFQ ALAALPGPAR TQLPVGFAAL TCAGPLPTRT LVHAVETAAP
TGERRFDLRI ADEGGRVLLA VDGLRVVAVA DDDPCTYLRP EWVPEALSAN GSDSPAVIVL
RPSVDAEGLV DEIGQSLHAV LRAASAALSQ DPAGLLRIVV VCPDARPAYA AVAAALRTLA
LEHSGFSGLV VHGGEPHPDE LRHVTGAPEA RVDEVRYVDG VRQVRRMVGF RPAARPQPRS
GGVYLVVGGT GAIGGHVAEH LRATRAPKAV VVAGRSVADV AVAQDVRRLV AEVKARYGRI
DGVVHAAGVH DDARALSKSA DQVDAVLAPK VRGVRNLVAA LGDEPLEFFA LFSSVAARTG
NLGQVDYAYA NAYLDEFAAA TPGLVSVCWP LWADGGMAVD DQTRRLFARR WGSEPLGTAD
ALRAFDRLVS GPDPVVAVVR PAAEPVGERP AVVAARPAPV DLDAGLRALA AGFLLVEPEE
IEPDIALLDL GFDSISLTGL INEVNERFGL DLLPTVLYEC PTLADFAEYL RGLDGFDASV
PDDLPVTAVE PDVTAAGPDV TAVGPEAPVS AAGPEDDVIA VIGMAGVLPG SPDLDAFWQH
LVAGDDLVRP VPEDRVDLRR DPAVASVSAG FLDDVRSFDA RRFGISPREA ALMDPQQRLF
LHTAWQAVAD AGYHPERLAG TETGLFVGVS ACDYDDLLHA HGVPVEAHTA SGLADCILAN
RVSYLLDLRG PSEAIDTACS SSLVAVHHAV RALRSGECDV ALAGGVNVLL SPGLFVAFQS
SGMLSEDGRC RTFDDAAAGY GRGEGCGVVV LKPLRAALAD GDQVIAVIRG SAVNHAGRGP
SLTAPNPEAQ ARVIARAYET AGVDPARVSY VEAHGTGTRL GDPIEVEGLK KAFAGVDARI
GLGAVKTNIG HLEAAAGIAG LLKVLLALRH GELPPTLHQD KPNPYVRLDG TPFRVVAQRT
PWTGDRVAGV SSFGFGGTNA HVVVESVTEP ASPSAVGPWP LVLSADSAEA LAEYRSRVAR
FLAHDRDLGR LCHTLATGRE ALGHRFAAVV ADRAEAVAVL TGSAEPRLDD ETSTWLGGAD
VDWSARWEAR PRLISAPVPP FAATPFWFDQ IVRPERKLVL RDPAALRPNG SAPALSPPVA
NGSAPAVVLP NLVDFEPEGP APVVVPVVAA EPEKPFVDGQ VARVIRESVA AVLGTAVDEI
AADTAFSDLG LDSIFRMELA RSLMAAFDVE LTAAQLYEHD TVDALAALIE GAASQPPPLP
AAPEPASVPE VVAAPEVVPG PSVAEIVEEA LERPLDRGLS FADNGLTSFD MLRAVGALEN
RYGALPKTLL FDRPTMAELT EFLAGRAARA GQPSQRGDRS IESPAVVDGE PVIYLKRNLP
GLGRLRDLVS DLDRRYAKEG GLAGRDIAPY AFLDTAREGY VNFSVRGDDL FAWSFVGAMD
HFHDLVADWM AWARRTGLRP NFLSLAHLTE VAGEPVTATP FGAVQRLDDL STFTTSGGRM
SRLRYLLGRF ERAGAVRTEE YRVGDDPATD GRIVALMDSW GDHKQMVNPY VGVVREEIRT
GRLDPRHRMF LTSVDGELVN AIIVTRIPSE QGYLLDLEFY PDSMPAGGLE HAIVEIIATT
AAEGCTSFSF GASFGVAISE SPNADPEVSE AIEELHSVGV FGSGNFQFKN KFRTTNTPIY
LCSPATGDRT SVTDVILMIA NPELTATKPE RATDTTPVEL TATTRSRPAH ASNGSTAAAP
AATAPARPSP PAPVRTAPVA TGGDVATEAG RAAVLAAHGH NALTVPTGLV PVDLVTDSWA
ERAEDFVAER ARQLAKLPTP ELTSHDWLPF TDVLPTRSGR SAEAMLCRGF PGPRGNVPHA
QAFPTWLLSL TDVGFEPKAV GDGRRLDPDA IAAAIDDRTS FVVVETSTNA GGGQPIGLAE
LREVRRITRE RGVPLVLDAT RIVENGVFLA PDDPWSAVRD LLSLADTATF SLSKDFGVAA
GGLIATNDPE LAARLHEDVR RRGWDVDLTA RNQIAAAVAD RDWVGTAVRR RMAAVEALGA
GLREAGIPLV EPVGGHCVLV DVAAMPAFAA QEHAVMSSLA WLYQGAGVRG APHLAAGAGA
VRLAVPVGFG PGDVAPVVDR IARLRTDSVP ELVTGGLRTP GDAARAVYQP VARVPEDVRH
ALRDERKPGD DNEAVLREHC PAVRRSVVSV AGTEVEVFTA GAGEPVLLMH PFNIGAGVFA
HQFAGLSRTN LVVSVHHPGV GATAAAPDIT LSGLAALERE ALRELGIDGP VHVVGASFGG
LVALTYALDF PAGTATLSLL GSSYKIGNRV GEINRLAVVA AEDLDRTIEG GGSSRLKRER
AAVEELLLRC ESMSPQIGLR YLDVFAARPD LLSRLDEVSV PTLVMQGRHD TVIPLKTAHL
LHGAIPGARY AEISDAGHFP YVTSPSRCNR VLAAFVAEHS VSEVRA
//
