ID K0K1G5_SACES Unreviewed; 321 AA.
AC K0K1G5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Daunorubicin/doxorubicin resistance ATP-binding protein DrrA {ECO:0000313|EMBL:CCH30699.1};
DE EC=3.6.3.- {ECO:0000313|EMBL:CCH30699.1};
GN OrderedLocusNames=BN6_34010 {ECO:0000313|EMBL:CCH30699.1};
OS Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC
OS 15066 / NRRL 15764).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH30699.1, ECO:0000313|Proteomes:UP000006281};
RN [1] {ECO:0000313|EMBL:CCH30699.1, ECO:0000313|Proteomes:UP000006281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC {ECO:0000313|Proteomes:UP000006281};
RX PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT comparison to the other completely sequenced Pseudonocardiaceae.";
RL BMC Genomics 13:465-465(2012).
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DR EMBL; HE804045; CCH30699.1; -; Genomic_DNA.
DR AlphaFoldDB; K0K1G5; -.
DR STRING; 1179773.BN6_34010; -.
DR KEGG; sesp:BN6_34010; -.
DR PATRIC; fig|1179773.3.peg.3403; -.
DR eggNOG; COG1131; Bacteria.
DR HOGENOM; CLU_000604_1_2_11; -.
DR BioCyc; SESP1179773:BN6_RS16465-MONOMER; -.
DR Proteomes; UP000006281; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:CCH30699.1};
KW Hydrolase {ECO:0000313|EMBL:CCH30699.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006281};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 10..240
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 321 AA; 34503 MW; AC9AE1E46C346116 CRC64;
MREENTVNAI ETSGLVKIFG DTRAVDGVDL TVPAGTVYGL LGPNGAGKTT TVRMLATLLR
PDDGEARVFG HDVRADPNAV RELVSLTGQY ASVDEDLTGT ENLVLLSRLI GYSRPRARER
AAQMLEAFGL TEAAGKQVKH YSGGMRRRLD IAASILNTPR LLFLDEPTTG LDPRSRNQVW
DIVRAVVSHG TTVLLTTQYL DEADQLASRI AVIDRGKVIA EGTKGELKAS VGEGAVHVRL
RDADRRSDAR ALLVRVLDAE VLLDADPLAL TARLTGRATE QAAEALAQLA REGITVDNFS
LGQPSLDEVF LALTDKKEAA A
//
