ID K0KBX7_WICCF Unreviewed; 984 AA.
AC K0KBX7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Exosome complex exonuclease {ECO:0000313|EMBL:CCH42570.1};
DE EC=3.1.13.- {ECO:0000313|EMBL:CCH42570.1};
GN Name=DIS3 {ECO:0000313|EMBL:CCH42570.1};
GN ORFNames=BN7_2114 {ECO:0000313|EMBL:CCH42570.1};
OS Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM
OS 3599 / NBRC 0793 / NRRL Y-1031 F-60-10) (Yeast) (Pichia ciferrii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=1206466 {ECO:0000313|EMBL:CCH42570.1, ECO:0000313|Proteomes:UP000009328};
RN [1] {ECO:0000313|EMBL:CCH42570.1, ECO:0000313|Proteomes:UP000009328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC Y-1031 F-60-10 {ECO:0000313|Proteomes:UP000009328};
RX PubMed=23193139; DOI=10.1128/EC.00258-12;
RA Schneider J., Andrea H., Blom J., Jaenicke S., Ruckert C., Schorsch C.,
RA Szczepanowski R., Farwick M., Goesmann A., Puhler A., Schaffer S.,
RA Tauch A., Kohler T., Brinkrolf K.;
RT "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10.";
RL Eukaryot. Cell 11:1582-1583(2012).
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH42570.1}.
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DR EMBL; CAIF01000049; CCH42570.1; -; Genomic_DNA.
DR AlphaFoldDB; K0KBX7; -.
DR STRING; 1206466.K0KBX7; -.
DR eggNOG; KOG2102; Eukaryota.
DR HOGENOM; CLU_002333_5_0_1; -.
DR InParanoid; K0KBX7; -.
DR Proteomes; UP000009328; Unassembled WGS sequence.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR InterPro; IPR033770; RRP44_S1.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF13638; PIN_4; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR Pfam; PF17215; Rrp44_S1; 1.
DR SMART; SM00670; PINc; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:CCH42570.1};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Hydrolase {ECO:0000313|EMBL:CCH42570.1};
KW Nuclease {ECO:0000313|EMBL:CCH42570.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 84..198
FT /note="PIN"
FT /evidence="ECO:0000259|SMART:SM00670"
FT DOMAIN 514..847
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT REGION 320..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 111442 MW; B165B4B234141907 CRC64;
MTTPAITKRK LTDGLTVTSK VFVRSRNGNA SKVVREHYLR NDIPCLSKSC SKCFEILTPD
AQGQLPKFVL SEDPLNIKKL GGAHYVIVDT NIILQSIDLL ENNQIFYDVI IPQTVLDEVR
NKSFPIYSRL RSLCKSDEKR FIVFHNDFNE ETFVKRLDNE TINDRNDRAI RELAKWYQKH
LDGKINIVLV TNDRLNREAA SKDGIISKSL LEYVGLYPNG EELKDLIPEE NTFKTRDSKN
GTTAYFKDYY PTSRLMGGLK NGTLYQGNIN ISSYNFLEGE ISVATLPKPL LILGSENLNR
SFNGDSVVVE ILPKSQWKKP SSMIVDEDQL NSNEDPENDQ SQLEINDKER RLLTQDAINT
QSSTTDELQP TGRVVGIVKR SWRSYVGQIV ENSVSKQTTN SAKSCFVKLM DRSLPRIRIK
TRRAQELLGQ KIVIAIDSWN ITSKNPEGHF VKSLGAADTV GAETEALLLE HDVEYRPFSK
NVLDCLPKEG HDWKVPEDLT DETVLKADPL LPKRKDFRDK LICSIDPPGC VDIDDALHAK
KLPNGNWEVG VHIADVTHFV KAGSALDAEG ASRGTSVYLV DKRIDMLPML LGTDLCSLKP
YVERFAFSVI WELDDDANII NVDYNKSIIK SREAFSYEQA QLRIDDKSNQ DELTVGMRAL
LHLSKKLKQQ RLDAGALNLA SPEVKVHMDS ETSDPGEVEI KKLLETNSLV EEFMLLANIS
VARKIFNEFP QTAMLRRHAA PPSTNFEKLN DMLRIKKNMS VSLESSKALA DSLDRCIDPK
DEYFNTLVRI MSTRCMMAAE YFSSGSYGYP EFRHYGLAVD IYTHFTSPIR RYCDVVAHRQ
LAAAISYEPL DLTHRDKTKM ELICKNINKR HRNAQFAGRA SIEYYVGQVM KNNESTETGY
VIRVFSNGIV VLVPKFGVES LIKLEDITSH VNDAIFKEDE YSLDFKLDNG ERRLVSVFDK
VKVDVKSVLD SSIGKRKAQL VLVD
//
