ID K0KJU4_WICCF Unreviewed; 915 AA.
AC K0KJU4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN Name=HUL4 {ECO:0000313|EMBL:CCH41378.1};
GN ORFNames=BN7_918 {ECO:0000313|EMBL:CCH41378.1};
OS Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM
OS 3599 / NBRC 0793 / NRRL Y-1031 F-60-10) (Yeast) (Pichia ciferrii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=1206466 {ECO:0000313|EMBL:CCH41378.1, ECO:0000313|Proteomes:UP000009328};
RN [1] {ECO:0000313|EMBL:CCH41378.1, ECO:0000313|Proteomes:UP000009328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC Y-1031 F-60-10 {ECO:0000313|Proteomes:UP000009328};
RX PubMed=23193139; DOI=10.1128/EC.00258-12;
RA Schneider J., Andrea H., Blom J., Jaenicke S., Ruckert C., Schorsch C.,
RA Szczepanowski R., Farwick M., Goesmann A., Puhler A., Schaffer S.,
RA Tauch A., Kohler T., Brinkrolf K.;
RT "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10.";
RL Eukaryot. Cell 11:1582-1583(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH41378.1}.
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DR EMBL; CAIF01000018; CCH41378.1; -; Genomic_DNA.
DR AlphaFoldDB; K0KJU4; -.
DR STRING; 1206466.K0KJU4; -.
DR eggNOG; KOG0941; Eukaryota.
DR HOGENOM; CLU_002173_5_1_1; -.
DR InParanoid; K0KJU4; -.
DR Proteomes; UP000009328; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR11254:SF440; E3 UBIQUITIN-PROTEIN LIGASE NEDD-4; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 572..915
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 342..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 883
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 915 AA; 105467 MW; 9D360EC114170FAC CRC64;
MNITENPHIQ VVAQIGSSSA GIDIISSSRD NNNNNNNNDN NSWLSSSMNL LRFGSIKKKK
DIEDDSSADT SISIDSPKED SIIIGHCKCC GSVVKYPEST KKFKCSICRC IINLIQLPDT
NNYESNEALS YKSVRNKIKE CQKQQHLNGE TNPHKIYKPL EEYLIHCFGT FKILNNSFKL
NKNESHLRHS TPNINFKEVK DTFLLILSLP TKKPFMKLLI ASNELLLRPN ELLSSASDLK
WLLILWEIPT LPQCLYHSKK QSSSLDTPEV KSLSYEITKK IIGFISNFDY NSLKYLAGWF
KNYSIDQFKH KVEFINLYIT FHLTRLINQH YKATGGIHSN IKSPRIEAPR SPQYNEYSES
PKLNNTTNSS NESRPSSSNS RPFLNLPITF HNGFSNWSSS RNIFYDHSED SKIIDFKLKV
GHYGNEWHLK SASRLLSVLN VSNKGKIPDY SFYNSLVDYI NVKQDFEMWQ NSFKLTSSNS
KTTSNKLILD LAGFTAPPKR IPQFTICQFP FLLSLGAKIS ILEYEARRTM ENKAEEAFIK
ALDKKQVLDV HLRIKVRRNH ISNDSLRCIK EQKDDLKKSL KVEFIGEPGI DAGGLKKEWF
GLLTKELFQQ ENGMFYYNEE SKLCWFAVLP LEKNDELYFM LGAVLGLAIY NSTILGLHFP
LALYKKILGK KVGIDDYLEL FPDTARGLLK LYEINNDELE NLDLFFETTY KNYFDEPITK
ELIPNGSKIK VNKSNLDNYI NEWVNFYLND SIESQFKNFQ NGFHNVIGGN SLSLFSPKEI
ELLICGNNDT CKIDINEFKS ITKYQGWSTR DLATNSTLIK WFWEWFENLN YQQQKKFLQF
ITGSDRIPAT GIHTMNIKIT KMPNYGPSIM NKSSSRLPVA HTCFNELCIY GYQTREEMWN
KLDWAINESK GFGLR
//