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Database: UniProt
Entry: K0KJU4_WICCF
LinkDB: K0KJU4_WICCF
Original site: K0KJU4_WICCF 
ID   K0KJU4_WICCF            Unreviewed;       915 AA.
AC   K0KJU4;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   Name=HUL4 {ECO:0000313|EMBL:CCH41378.1};
GN   ORFNames=BN7_918 {ECO:0000313|EMBL:CCH41378.1};
OS   Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM
OS   3599 / NBRC 0793 / NRRL Y-1031 F-60-10) (Yeast) (Pichia ciferrii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX   NCBI_TaxID=1206466 {ECO:0000313|EMBL:CCH41378.1, ECO:0000313|Proteomes:UP000009328};
RN   [1] {ECO:0000313|EMBL:CCH41378.1, ECO:0000313|Proteomes:UP000009328}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC   Y-1031 F-60-10 {ECO:0000313|Proteomes:UP000009328};
RX   PubMed=23193139; DOI=10.1128/EC.00258-12;
RA   Schneider J., Andrea H., Blom J., Jaenicke S., Ruckert C., Schorsch C.,
RA   Szczepanowski R., Farwick M., Goesmann A., Puhler A., Schaffer S.,
RA   Tauch A., Kohler T., Brinkrolf K.;
RT   "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10.";
RL   Eukaryot. Cell 11:1582-1583(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCH41378.1}.
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DR   EMBL; CAIF01000018; CCH41378.1; -; Genomic_DNA.
DR   AlphaFoldDB; K0KJU4; -.
DR   STRING; 1206466.K0KJU4; -.
DR   eggNOG; KOG0941; Eukaryota.
DR   HOGENOM; CLU_002173_5_1_1; -.
DR   InParanoid; K0KJU4; -.
DR   Proteomes; UP000009328; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR11254:SF440; E3 UBIQUITIN-PROTEIN LIGASE NEDD-4; 1.
DR   PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          572..915
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          342..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..380
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        883
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   915 AA;  105467 MW;  9D360EC114170FAC CRC64;
     MNITENPHIQ VVAQIGSSSA GIDIISSSRD NNNNNNNNDN NSWLSSSMNL LRFGSIKKKK
     DIEDDSSADT SISIDSPKED SIIIGHCKCC GSVVKYPEST KKFKCSICRC IINLIQLPDT
     NNYESNEALS YKSVRNKIKE CQKQQHLNGE TNPHKIYKPL EEYLIHCFGT FKILNNSFKL
     NKNESHLRHS TPNINFKEVK DTFLLILSLP TKKPFMKLLI ASNELLLRPN ELLSSASDLK
     WLLILWEIPT LPQCLYHSKK QSSSLDTPEV KSLSYEITKK IIGFISNFDY NSLKYLAGWF
     KNYSIDQFKH KVEFINLYIT FHLTRLINQH YKATGGIHSN IKSPRIEAPR SPQYNEYSES
     PKLNNTTNSS NESRPSSSNS RPFLNLPITF HNGFSNWSSS RNIFYDHSED SKIIDFKLKV
     GHYGNEWHLK SASRLLSVLN VSNKGKIPDY SFYNSLVDYI NVKQDFEMWQ NSFKLTSSNS
     KTTSNKLILD LAGFTAPPKR IPQFTICQFP FLLSLGAKIS ILEYEARRTM ENKAEEAFIK
     ALDKKQVLDV HLRIKVRRNH ISNDSLRCIK EQKDDLKKSL KVEFIGEPGI DAGGLKKEWF
     GLLTKELFQQ ENGMFYYNEE SKLCWFAVLP LEKNDELYFM LGAVLGLAIY NSTILGLHFP
     LALYKKILGK KVGIDDYLEL FPDTARGLLK LYEINNDELE NLDLFFETTY KNYFDEPITK
     ELIPNGSKIK VNKSNLDNYI NEWVNFYLND SIESQFKNFQ NGFHNVIGGN SLSLFSPKEI
     ELLICGNNDT CKIDINEFKS ITKYQGWSTR DLATNSTLIK WFWEWFENLN YQQQKKFLQF
     ITGSDRIPAT GIHTMNIKIT KMPNYGPSIM NKSSSRLPVA HTCFNELCIY GYQTREEMWN
     KLDWAINESK GFGLR
//
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