ID   K0KU91_WICCF            Unreviewed;      1010 AA.
AC   K0KU91;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=WD40-repeat-containing protein {ECO:0000313|EMBL:CCH46746.1};
GN   ORFNames=BN7_6344 {ECO:0000313|EMBL:CCH46746.1};
OS   Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM
OS   3599 / NBRC 0793 / NRRL Y-1031 F-60-10) (Yeast) (Pichia ciferrii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX   NCBI_TaxID=1206466 {ECO:0000313|EMBL:CCH46746.1, ECO:0000313|Proteomes:UP000009328};
RN   [1] {ECO:0000313|EMBL:CCH46746.1, ECO:0000313|Proteomes:UP000009328}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC   Y-1031 F-60-10 {ECO:0000313|Proteomes:UP000009328};
RX   PubMed=23193139; DOI=10.1128/EC.00258-12;
RA   Schneider J., Andrea H., Blom J., Jaenicke S., Ruckert C., Schorsch C.,
RA   Szczepanowski R., Farwick M., Goesmann A., Puhler A., Schaffer S.,
RA   Tauch A., Kohler T., Brinkrolf K.;
RT   "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10.";
RL   Eukaryot. Cell 11:1582-1583(2012).
CC   -!- SIMILARITY: Belongs to the WD repeat WDR59 family.
CC       {ECO:0000256|ARBA:ARBA00038452}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCH46746.1}.
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DR   EMBL; CAIF01000267; CCH46746.1; -; Genomic_DNA.
DR   AlphaFoldDB; K0KU91; -.
DR   STRING; 1206466.K0KU91; -.
DR   eggNOG; KOG0309; Eukaryota.
DR   HOGENOM; CLU_001497_0_0_1; -.
DR   InParanoid; K0KU91; -.
DR   Proteomes; UP000009328; Unassembled WGS sequence.
DR   GO; GO:0005773; C:vacuole; IEA:UniProtKB-KW.
DR   CDD; cd16488; mRING-H2-C3H3C2_Mio-like; 1.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR006575; RWD_dom.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR049567; WDR59-like.
DR   InterPro; IPR049566; WDR59_RTC1-like_RING_Znf.
DR   InterPro; IPR001841; Znf_RING.
DR   PANTHER; PTHR46170; GATOR COMPLEX PROTEIN WDR59; 1.
DR   PANTHER; PTHR46170:SF1; GATOR COMPLEX PROTEIN WDR59; 1.
DR   Pfam; PF05773; RWD; 1.
DR   Pfam; PF00400; WD40; 2.
DR   Pfam; PF17120; zf-RING_16; 1.
DR   SMART; SM00591; RWD; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50908; RWD; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Vacuole {ECO:0000256|ARBA:ARBA00022554};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   REPEAT          121..157
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          208..243
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          440..545
FT                   /note="RWD"
FT                   /evidence="ECO:0000259|PROSITE:PS50908"
FT   DOMAIN          963..1000
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          686..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1010 AA;  115517 MW;  67E01930D5263E35 CRC64;
     MNKFGNTLSK IDQKLLHIDS VILMANITSP YESVTFGNSL SLRVDGGVGA VSINPSGLYV
     VDLDDPFSPP RWFHHMTSWE VADVQWSPHS SKPSWVISTS NQKAMVWNLA RSTSNAIEFV
     LHGHSRAITD INFHPDHPEL LATCSVDTSV LAWDTRSPKR PFYTVSDWRA GASQVKWNFK
     NPNILSSSHD HYFYVWDLRN NAKPLLKINA HERKINGVDF SRTKESEIIT CSNDHTVKFW
     DLSKDINNPV STINTEFPVW RARHLPFGEG CSIMPLRGGN NSIYLSSKQD QQGDSKLKSC
     YIFKGHTDRI TDFLWRQRHS SSEVDDRDFQ LVTWSKDCDL RLWSMNDDIY EKVGFQKGEP
     KKLPTYTYKS YREEPGAYLN NGYAMKKTKD TFVSSKGETI NSEAHLSWIS GVRIGRSAFA
     PPIDQNPNVN IENLPDNLGE EVSVVGHKFP KVKFEKISVS TGTLVLSLNG PWGNTSEELV
     FLRIEIKYPK TYPSEPPTFR IEENRDLEQS KRQEILKTLN EIVKKYASVN RFSLESSLRY
     FMGEKIELDN LEKDDDDFSL QLEEFDDLSS IPSSASSSES EAEDEELMPL THSGLMSAPL
     VDSTPIPKGC GACWTKTGEL LCFFIPKQAK QQNIIKFDQK GFSNQMTLNN DDQYSDDSLS
     DDLNDVLKDD VKSRSKIPGV FRMQNYNNNH QNRAPSLPTE RSGATQQNSV TKNIVAIFDF
     KHLIPTKLEL AKEYRISGGT PCDLSAHNSE VCTKYGYTDL ADSWRILSTI FSQNFHWGTH
     PFGKSWLIKE LMDYYERLGD VQMLAMLSCV IYGSRFQNND QFAMSTIETS SVNKENRSLS
     IHSYNDTNSI YNYSESAFRL PFSRSSSVLA KEPEKPISIK IEMMNEAELG FAEESFNYNS
     IEDETFDEPR FTRYREQYAN ILYTWELPFS RVEILKFNQN INESDIDIYR SKIRWLKKAV
     KCCNYCGLEV RRRLFTCYKC GHVLHADCAT EWWNDSNECP TGCGCSCIDE
//