ID K0KVI6_WICCF Unreviewed; 1176 AA.
AC K0KVI6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=F-box/LRR-repeat protein 2 {ECO:0000313|EMBL:CCH45942.1};
GN ORFNames=BN7_5529 {ECO:0000313|EMBL:CCH45942.1};
OS Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM
OS 3599 / NBRC 0793 / NRRL Y-1031 F-60-10) (Yeast) (Pichia ciferrii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=1206466 {ECO:0000313|EMBL:CCH45942.1, ECO:0000313|Proteomes:UP000009328};
RN [1] {ECO:0000313|EMBL:CCH45942.1, ECO:0000313|Proteomes:UP000009328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC Y-1031 F-60-10 {ECO:0000313|Proteomes:UP000009328};
RX PubMed=23193139; DOI=10.1128/EC.00258-12;
RA Schneider J., Andrea H., Blom J., Jaenicke S., Ruckert C., Schorsch C.,
RA Szczepanowski R., Farwick M., Goesmann A., Puhler A., Schaffer S.,
RA Tauch A., Kohler T., Brinkrolf K.;
RT "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10.";
RL Eukaryot. Cell 11:1582-1583(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH45942.1}.
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DR EMBL; CAIF01000219; CCH45942.1; -; Genomic_DNA.
DR AlphaFoldDB; K0KVI6; -.
DR STRING; 1206466.K0KVI6; -.
DR eggNOG; KOG0498; Eukaryota.
DR eggNOG; KOG0500; Eukaryota.
DR eggNOG; KOG1947; Eukaryota.
DR HOGENOM; CLU_006113_0_0_1; -.
DR InParanoid; K0KVI6; -.
DR Proteomes; UP000009328; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 2.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF13516; LRR_6; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00367; LRR_CC; 7.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 2.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 154..271
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 394..521
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 777..824
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1176 AA; 130718 MW; B08A7F19E07BF3F6 CRC64;
MRKKSSIARS KPSRQSPLAS KGNSTYSAIN NTSDDSKNSQ PYTRGTSPLT AVISESDFAS
NNKRQDLHCD QNSSNQDLIP TPTSLSSKSS YDSNNIIPRD LHPQNNENLH TIQQKQSNNH
NQEEIDNEDE LEIESLTRYN IPPQLLEKLT TFPLFRNAPR TFHKAIAGRL KLVQHHPQEY
IVKFGEPAKS MYLILRGSVA VTSPDGEAVH AELVSGQFFG EIGILFNRPR TATVIAKTKV
LLGVLTADNF NSVLPDFPIV ERMIRDEAQE RLSMQDKRFR NGVTNINFKS NSLTSSISNA
SGRVLINEND QNNTRSSVIA TANASIPGPS IPPHTKSEPS ALAQIPSSLL DNVSQNLRKS
SMVINNQTRK SLPKIHDNVD NSIPTRDFLR SLPMFTLLPS NIIHELVLGV EPQRFEPFET
IVKKGEQARD IYFIVNGEVE VLSPKRISLA SSKGDQDKKV DRVLARLGTG QYFGEMAFLQ
SITPSDDDLS PEQLKSERTA DIRSVSTVDV LIVSGDQLEN LYSRYPRICD EMRDTAKKRN
DRNQITSDHD SAKSFKPEND WNLLKDSPFS KWKGFASTNT DRKASTELHE PVPKRRRSNS
YVQSSNSLLT FDVSPSASPS PPSKRTKNIA ITSDPIFKQP KFTEPDIPKR AKSPLQDQSP
SSSSSQPSSS MTALLDSALQ SSFSTGPSST FSKPSMFNDK FEFQRRKSIA TISQTVDPLK
DSSSSSPLTL SVPPLNPVLP SINQFPSSQK SSQPFQYMNH AKRVRLQNIG GRRRSSVLST
GPLPDRILLN IFKLLPLPDL MKLRIICRRW RQLLYVAPGF FETLDLKPYN ISIDDKALIQ
IIDFVGSRPR IIDISDCFHI TDVGFCYMVN EIGMSGFIQT IKMRSVWEVS AMAIMDVAVP
SIGHHIIELD LSNCRKVRDD VVERLIGWKN KPGVSASQQQ QSVSNGYALE GPVPGMEEFD
NHEASIGCAN LKILNLGYCK HLTDRSMYHI ALHANDRIES LDLTRCTTIT DAGFAYWAYQ
PFPNLRKLKL SDCTFLSDKS IIAITSSAQG LHSLDLSFCC ALTDVSVEVL CLGCPGLKHL
DLSFCGSAIS DSSLLAISLH LRQLESLVIK GCVRVTRAGV DALLSSSLPL RYLDISQCRN
AHYYGGQIPA PKINPNPNSK SAYVTTSYDR VVEIVI
//
