ID K0KYJ0_WICCF Unreviewed; 719 AA.
AC K0KYJ0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Carnitine O-acetyltransferase {ECO:0000313|EMBL:CCH47142.1};
DE EC=2.3.1.7 {ECO:0000313|EMBL:CCH47142.1};
GN Name=YAT1 {ECO:0000313|EMBL:CCH47142.1};
GN ORFNames=BN7_6753 {ECO:0000313|EMBL:CCH47142.1};
OS Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM
OS 3599 / NBRC 0793 / NRRL Y-1031 F-60-10) (Yeast) (Pichia ciferrii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=1206466 {ECO:0000313|EMBL:CCH47142.1, ECO:0000313|Proteomes:UP000009328};
RN [1] {ECO:0000313|EMBL:CCH47142.1, ECO:0000313|Proteomes:UP000009328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC Y-1031 F-60-10 {ECO:0000313|Proteomes:UP000009328};
RX PubMed=23193139; DOI=10.1128/EC.00258-12;
RA Schneider J., Andrea H., Blom J., Jaenicke S., Ruckert C., Schorsch C.,
RA Szczepanowski R., Farwick M., Goesmann A., Puhler A., Schaffer S.,
RA Tauch A., Kohler T., Brinkrolf K.;
RT "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10.";
RL Eukaryot. Cell 11:1582-1583(2012).
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH47142.1}.
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DR EMBL; CAIF01000334; CCH47142.1; -; Genomic_DNA.
DR AlphaFoldDB; K0KYJ0; -.
DR STRING; 1206466.K0KYJ0; -.
DR eggNOG; KOG3719; Eukaryota.
DR HOGENOM; CLU_013513_4_0_1; -.
DR InParanoid; K0KYJ0; -.
DR Proteomes; UP000009328; Unassembled WGS sequence.
DR GO; GO:0004092; F:carnitine O-acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR042572; Carn_acyl_trans_N.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF29; MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 13..637
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT REGION 529..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 317
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 719 AA; 82171 MW; 63894BEB8B42174F CRC64;
MSTFDYQDKL EKLPIPDLKS TCENYLSVLK PLQTEQEHKE TIKATESFLK GIGPYLDDQL
RKYANSRNSY IEQFWFDSYL NSDSPVVLNL NPFFLLEDDP TPINNTQIKR ASSLTQSSLE
FIRALRREEL PPDMVRGVPL SMDQYHKLFG SSRIPTKTGC IMQTDSNSHH IVVMSKSQFY
WFDVLDKNND LILTDDEISI NFESILKDSQ KSTPSELARS SFGVLTTENR KNWANLRNNL
INDEINYKIL KIIDSALFMV ILDDLNLETL NDLSMNMLCG ISKLDKGVQV GTCTNRWYDK
LQLIITKNAK AGINFEHTGV DGHTVLRFCS DIYTDSILKF AKSINSNSPS IWKTKSPLLK
NQNSIDTNVI TIPRKLEWNL TSDLSLALRF AETRISDLIS QYEFACLEFK NYGSDFIKKL
KCSPDAFVQM SFQAAYYVLY GKVECTYEPA MTKQFFHGRT ESIRTVSLES NQFVRRFFED
SKNLEKLDLL QKACSKHSKT TKNCSNGQGQ DRHLYALFNI WKRYVADQDQ DDESSNDNGH
NSDDDNSDVT IGNDSDPVLE KLNKNEIPSI FADSGWDKIN NSIISTSNCG NPALKNFGFG
PTSSNGFGIA YIIKSNSITV CVSSKHRQTQ RFIDTLKNYY EEISHIYNEE FLKPKIDQSS
RGRSTPRSGN LNYLLGGYGY FDLEDDEIKS RGNSPERFGF KKAGFTSRQL SEKLRLAEY
//
