ID K0L061_WICCF Unreviewed; 271 AA.
AC K0L061;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Transcriptional activator HAP2 {ECO:0000256|RuleBase:RU367155};
GN ORFNames=BN7_6362 {ECO:0000313|EMBL:CCH46763.1};
OS Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM
OS 3599 / NBRC 0793 / NRRL Y-1031 F-60-10) (Yeast) (Pichia ciferrii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=1206466 {ECO:0000313|EMBL:CCH46763.1, ECO:0000313|Proteomes:UP000009328};
RN [1] {ECO:0000313|EMBL:CCH46763.1, ECO:0000313|Proteomes:UP000009328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC Y-1031 F-60-10 {ECO:0000313|Proteomes:UP000009328};
RX PubMed=23193139; DOI=10.1128/EC.00258-12;
RA Schneider J., Andrea H., Blom J., Jaenicke S., Ruckert C., Schorsch C.,
RA Szczepanowski R., Farwick M., Goesmann A., Puhler A., Schaffer S.,
RA Tauch A., Kohler T., Brinkrolf K.;
RT "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10.";
RL Eukaryot. Cell 11:1582-1583(2012).
CC -!- FUNCTION: Component of the sequence-specific heterotrimeric
CC transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3'
CC box motif found in the promoters of its target genes.
CC {ECO:0000256|RuleBase:RU367155}.
CC -!- SUBUNIT: Heterotrimer. {ECO:0000256|RuleBase:RU367155}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367155}.
CC -!- SIMILARITY: Belongs to the NFYA/HAP2 subunit family.
CC {ECO:0000256|RuleBase:RU367155}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH46763.1}.
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DR EMBL; CAIF01000271; CCH46763.1; -; Genomic_DNA.
DR AlphaFoldDB; K0L061; -.
DR STRING; 1206466.K0L061; -.
DR eggNOG; KOG1561; Eukaryota.
DR HOGENOM; CLU_1027466_0_0_1; -.
DR InParanoid; K0L061; -.
DR Proteomes; UP000009328; Unassembled WGS sequence.
DR GO; GO:0016602; C:CCAAT-binding factor complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.2430; -; 1.
DR InterPro; IPR018362; CCAAT-binding_factor_CS.
DR InterPro; IPR001289; NFYA.
DR PANTHER; PTHR12632:SF6; NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT ALPHA; 1.
DR PANTHER; PTHR12632; TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED; 1.
DR Pfam; PF02045; CBFB_NFYA; 1.
DR PRINTS; PR00616; CCAATSUBUNTB.
DR SMART; SM00521; CBF; 1.
DR PROSITE; PS00686; NFYA_HAP2_1; 1.
DR PROSITE; PS51152; NFYA_HAP2_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU367155};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367155};
KW Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU367155};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU367155}.
FT REGION 18..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 271 AA; 30531 MW; EDF6460ED7559854 CRC64;
MSLNSPQIHN NQYLSKQSYY NSPLDNNFQD PTTSSQHQQH FQSNTNNQNI TSSSTGSNDS
QQRQIQPPIP QNSRPQSYEE FSNNFSSIAG LNLNFNSNTT TGSSNSNQPS ESSNYITTPN
DNQSQPHSSG PESNNTLEQT PPTTNTTNTT TTTTTTQSQA PVEQPFYVNA KQYHRILKRR
IARAKLEENL KVARGRRPYL HESRHKHAMR RPRGQGGRFL TAAEIAERDR LEKEKADSNG
NDDNSNNIDQ SNNQNQNNSL KNETISNQAF N
//
