ID K0NBW7_DESTT Unreviewed; 684 AA.
AC K0NBW7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=TOL2_C00160 {ECO:0000313|EMBL:CCK78186.1};
OS Desulfobacula toluolica (strain DSM 7467 / Tol2).
OC Bacteria; Thermodesulfobacteriota; Desulfobacteria; Desulfobacterales;
OC Desulfobacteraceae; Desulfobacula.
OX NCBI_TaxID=651182 {ECO:0000313|EMBL:CCK78186.1, ECO:0000313|Proteomes:UP000007347};
RN [1] {ECO:0000313|EMBL:CCK78186.1, ECO:0000313|Proteomes:UP000007347}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7467 / Tol2 {ECO:0000313|Proteomes:UP000007347};
RX PubMed=23088741; DOI=10.1111/j.1462-2920.2012.02885.x;
RA Wohlbrand L., Jacob J.H., Kube M., Mussmann M., Jarling R., Beck A.,
RA Amann R., Wilkes H., Reinhardt R., Rabus R.;
RT "Complete genome, catabolic sub-proteomes and key-metabolites of
RT Desulfobacula toluolica Tol2, a marine, aromatic compound-degrading,
RT sulfate-reducing bacterium.";
RL Environ. Microbiol. 15:1334-55(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FO203503; CCK78186.1; -; Genomic_DNA.
DR RefSeq; WP_014955544.1; NC_018645.1.
DR AlphaFoldDB; K0NBW7; -.
DR STRING; 651182.TOL2_C00160; -.
DR REBASE; 53405; M.DtoTol2ORF160P.
DR KEGG; dto:TOL2_C00160; -.
DR PATRIC; fig|651182.5.peg.17; -.
DR HOGENOM; CLU_012122_0_0_7; -.
DR OMA; TRHFYKY; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000007347; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933:SF3; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:CCK78186.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007347};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000313|EMBL:CCK78186.1}.
FT DOMAIN 13..150
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 167..471
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 684 AA; 79155 MW; 1686A604F5042DD8 CRC64;
MKQIVDKDKL NNLTNEIWKS AERLRGKFKA YEYQTVILPI IVIRRLECVL IQWRENQAAD
LKVKRPGVKD KNILELVKKL ELNSKKAPFS NTTAWTLEKI CAEDPTLMEK NFRAYINGFS
DNVQEIIEHF NYREIIGRMV KNSRLSPILN QYAKEPLGPD ELTNLEMGYV YEELLRRFSE
QSGEEAGEHF TPREVIRLMV ELLEIPLPQK HISVYDPACG TGGMLSVAKE YLYDRAATDM
EKANVQRLVT LHGHELQPGN YAICKADMLI KEEDAKIFFG NSLIPDAQNS PEPGDQLAAS
KYKFDYMLSN PPFGVTWGGK DGYEHEARKF KTTRYAAGMP RTNDGAFLFL QTMLSKMKPV
KNGGSKIAII FNGSPLSNGD CGSGESEIRR WILENDWLDA IVMLPDQLFY NTGIFTYIWL
LSNKKPERHK NNVMLIDGRS YYEKEPKSFG NKRNRISAHH METIKDYFQN GWEKGFENDH
VKIFNTTDFA FHKVSVVFWQ TNEKDEPGFV TEPYTKALTP ANITKEQTFY ESDLKFSIVL
TSKERETTIS FTLTPEDLFS KVFEKEIKTA FKQEIKILTK ALKTASEKTR AVKAFIKDLD
KSVVFTHRHY VSDTEYIPFG EDIEAFLKRE IEKPIIRWKD SPQLGYEILP NKYFYTYEPP
QPADELLKAF WALEKEAEEM LKKL
//