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Database: UniProt
Entry: K0NBW7_DESTT
LinkDB: K0NBW7_DESTT
Original site: K0NBW7_DESTT 
ID   K0NBW7_DESTT            Unreviewed;       684 AA.
AC   K0NBW7;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   OrderedLocusNames=TOL2_C00160 {ECO:0000313|EMBL:CCK78186.1};
OS   Desulfobacula toluolica (strain DSM 7467 / Tol2).
OC   Bacteria; Thermodesulfobacteriota; Desulfobacteria; Desulfobacterales;
OC   Desulfobacteraceae; Desulfobacula.
OX   NCBI_TaxID=651182 {ECO:0000313|EMBL:CCK78186.1, ECO:0000313|Proteomes:UP000007347};
RN   [1] {ECO:0000313|EMBL:CCK78186.1, ECO:0000313|Proteomes:UP000007347}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7467 / Tol2 {ECO:0000313|Proteomes:UP000007347};
RX   PubMed=23088741; DOI=10.1111/j.1462-2920.2012.02885.x;
RA   Wohlbrand L., Jacob J.H., Kube M., Mussmann M., Jarling R., Beck A.,
RA   Amann R., Wilkes H., Reinhardt R., Rabus R.;
RT   "Complete genome, catabolic sub-proteomes and key-metabolites of
RT   Desulfobacula toluolica Tol2, a marine, aromatic compound-degrading,
RT   sulfate-reducing bacterium.";
RL   Environ. Microbiol. 15:1334-55(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; FO203503; CCK78186.1; -; Genomic_DNA.
DR   RefSeq; WP_014955544.1; NC_018645.1.
DR   AlphaFoldDB; K0NBW7; -.
DR   STRING; 651182.TOL2_C00160; -.
DR   REBASE; 53405; M.DtoTol2ORF160P.
DR   KEGG; dto:TOL2_C00160; -.
DR   PATRIC; fig|651182.5.peg.17; -.
DR   HOGENOM; CLU_012122_0_0_7; -.
DR   OMA; TRHFYKY; -.
DR   OrthoDB; 9784823at2; -.
DR   Proteomes; UP000007347; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.1260.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR022749; D12N6_MeTrfase_N.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR038333; T1MK-like_N_sf.
DR   PANTHER; PTHR42933:SF3; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR   PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR   Pfam; PF12161; HsdM_N; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:CCK78186.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007347};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   Transferase {ECO:0000313|EMBL:CCK78186.1}.
FT   DOMAIN          13..150
FT                   /note="N6 adenine-specific DNA methyltransferase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12161"
FT   DOMAIN          167..471
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   684 AA;  79155 MW;  1686A604F5042DD8 CRC64;
     MKQIVDKDKL NNLTNEIWKS AERLRGKFKA YEYQTVILPI IVIRRLECVL IQWRENQAAD
     LKVKRPGVKD KNILELVKKL ELNSKKAPFS NTTAWTLEKI CAEDPTLMEK NFRAYINGFS
     DNVQEIIEHF NYREIIGRMV KNSRLSPILN QYAKEPLGPD ELTNLEMGYV YEELLRRFSE
     QSGEEAGEHF TPREVIRLMV ELLEIPLPQK HISVYDPACG TGGMLSVAKE YLYDRAATDM
     EKANVQRLVT LHGHELQPGN YAICKADMLI KEEDAKIFFG NSLIPDAQNS PEPGDQLAAS
     KYKFDYMLSN PPFGVTWGGK DGYEHEARKF KTTRYAAGMP RTNDGAFLFL QTMLSKMKPV
     KNGGSKIAII FNGSPLSNGD CGSGESEIRR WILENDWLDA IVMLPDQLFY NTGIFTYIWL
     LSNKKPERHK NNVMLIDGRS YYEKEPKSFG NKRNRISAHH METIKDYFQN GWEKGFENDH
     VKIFNTTDFA FHKVSVVFWQ TNEKDEPGFV TEPYTKALTP ANITKEQTFY ESDLKFSIVL
     TSKERETTIS FTLTPEDLFS KVFEKEIKTA FKQEIKILTK ALKTASEKTR AVKAFIKDLD
     KSVVFTHRHY VSDTEYIPFG EDIEAFLKRE IEKPIIRWKD SPQLGYEILP NKYFYTYEPP
     QPADELLKAF WALEKEAEEM LKKL
//
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