ID K0NE71_DESTT Unreviewed; 719 AA.
AC K0NE71;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=CRISPR-associated helicase, Cas3 family {ECO:0000313|EMBL:CCK79125.1};
GN OrderedLocusNames=TOL2_C09600 {ECO:0000313|EMBL:CCK79125.1};
OS Desulfobacula toluolica (strain DSM 7467 / Tol2).
OC Bacteria; Thermodesulfobacteriota; Desulfobacteria; Desulfobacterales;
OC Desulfobacteraceae; Desulfobacula.
OX NCBI_TaxID=651182 {ECO:0000313|EMBL:CCK79125.1, ECO:0000313|Proteomes:UP000007347};
RN [1] {ECO:0000313|EMBL:CCK79125.1, ECO:0000313|Proteomes:UP000007347}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7467 / Tol2 {ECO:0000313|Proteomes:UP000007347};
RX PubMed=23088741; DOI=10.1111/j.1462-2920.2012.02885.x;
RA Wohlbrand L., Jacob J.H., Kube M., Mussmann M., Jarling R., Beck A.,
RA Amann R., Wilkes H., Reinhardt R., Rabus R.;
RT "Complete genome, catabolic sub-proteomes and key-metabolites of
RT Desulfobacula toluolica Tol2, a marine, aromatic compound-degrading,
RT sulfate-reducing bacterium.";
RL Environ. Microbiol. 15:1334-55(2013).
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; FO203503; CCK79125.1; -; Genomic_DNA.
DR RefSeq; WP_014956475.1; NC_018645.1.
DR AlphaFoldDB; K0NE71; -.
DR STRING; 651182.TOL2_C09600; -.
DR KEGG; dto:TOL2_C09600; -.
DR PATRIC; fig|651182.5.peg.1152; -.
DR HOGENOM; CLU_009347_1_1_7; -.
DR OrthoDB; 9810236at2; -.
DR Proteomes; UP000007347; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF16; CRISPR-ASSOCIATED NUCLEASE_HELICASE CAS3-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007347}.
FT DOMAIN 11..192
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
SQ SEQUENCE 719 AA; 81685 MW; 2D5A55B3F994F46A CRC64;
MDVCDHIKAK GAPEFTTLYA HLCQVKSAIK VFAGYLNFDV ETAKLGAVFH DIGKASPIFQ
ERLVSKYKTG QSTFRHEIAS CFFLSLVEKT YHPQLIEMII AHHKSIENDK GLKGILDLEE
NEDDIFEFHI EHWDVWKLDA LKILAGFGIN SRDIGYDEAK ENYFKVLEYC ENTIMNNGYS
EWRGLLMSAD HFASALSSAA PDYLPHTFKK PILEFYNRTS QLYPLSLKKA SSNRPHTMVV
ACTGAGKTDY LFRRCRGRVF YTLPFQASIN AMFKRVKTDL IKLNPNLDIR VLHSSSKISS
GAESHEDMLL QRLVGSSVKV LTPYQLASII FATRGFESMI EDLKGCDVIL DEIHTYDNVS
KSIVLKIVEV LNHIGCRIHI GTATMSSSLY NEIIDLLGRD FVSEISLDSI ELEKFDRHIL
HKIGSWDDAH AVIKEAIKKN NKILLVCNRV DSAQEMFEIV KEAFSDIPLL LIHSRFKRGD
RRDKEASLLG LDSQGNTTFE FNTSSNACIV VSTQVVEVSL DISFDLMITE TAPIDSLIQR
FGRINRKRTP ATIGTYKPVY VIAPPEDEKA ARPYELEILR KSYAVLDHDQ VLHESDYQEK
INCVYPDLSY TSIENHTAYK GNGRWNVPML THRDRSILLE LLEVDSVNCI VDSDCQAYEQ
AGFEDQMMLE IPVRYYAVKN YFQLNFGSNP FVIPDSGYSR ETGLDLAKAN DRKADLNFL
//
