ID   K0NLS8_DESTT            Unreviewed;      1289 AA.
AC   K0NLS8;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Cya: adenylate cyclase {ECO:0000313|EMBL:CCK79612.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:CCK79612.1};
GN   Name=cyaA2 {ECO:0000313|EMBL:CCK79612.1};
GN   OrderedLocusNames=TOL2_C14490 {ECO:0000313|EMBL:CCK79612.1};
OS   Desulfobacula toluolica (strain DSM 7467 / Tol2).
OC   Bacteria; Thermodesulfobacteriota; Desulfobacteria; Desulfobacterales;
OC   Desulfobacteraceae; Desulfobacula.
OX   NCBI_TaxID=651182 {ECO:0000313|EMBL:CCK79612.1, ECO:0000313|Proteomes:UP000007347};
RN   [1] {ECO:0000313|EMBL:CCK79612.1, ECO:0000313|Proteomes:UP000007347}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7467 / Tol2 {ECO:0000313|Proteomes:UP000007347};
RX   PubMed=23088741; DOI=10.1111/j.1462-2920.2012.02885.x;
RA   Wohlbrand L., Jacob J.H., Kube M., Mussmann M., Jarling R., Beck A.,
RA   Amann R., Wilkes H., Reinhardt R., Rabus R.;
RT   "Complete genome, catabolic sub-proteomes and key-metabolites of
RT   Desulfobacula toluolica Tol2, a marine, aromatic compound-degrading,
RT   sulfate-reducing bacterium.";
RL   Environ. Microbiol. 15:1334-55(2013).
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DR   EMBL; FO203503; CCK79612.1; -; Genomic_DNA.
DR   RefSeq; WP_014956958.1; NC_018645.1.
DR   STRING; 651182.TOL2_C14490; -.
DR   KEGG; dto:TOL2_C14490; -.
DR   HOGENOM; CLU_262373_0_0_7; -.
DR   OrthoDB; 5436892at2; -.
DR   Proteomes; UP000007347; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:InterPro.
DR   Gene3D; 2.160.20.80; E3 ubiquitin-protein ligase SopA; 1.
DR   InterPro; IPR001646; 5peptide_repeat.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   InterPro; IPR016024; ARM-type_fold.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   Pfam; PF13599; Pentapeptide_4; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF141571; Pentapeptide repeat-like; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:CCK79612.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007347}.
FT   DOMAIN          668..860
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   1289 AA;  149222 MW;  E41007E0B2234FDB CRC64;
     MDAVLKDFDF NMFEAQWKKL SEEKQTIIVE IAEQLDPADA IIAVLAGITS YHFHLRNNAK
     RSLETIQHKI HALLADPSDK EGFLQGMKAS ASVCARICAY IRPGLHFNEL SYFFTKLLEF
     EGKGAFFAYR LVYRGLVCVS DMEKIISNVS EHMKLAFVDQ YIQTSPSARL KFGLSFKGIL
     RSIQHRKAVV EFYAGLFDRR RDADPILYNI NAGLRDPDKI IFNEIQSQSP DIKIMGLKAL
     SMMVKKISPV LLINILKADT NENVRLVIYK IIENSSKGMY PELFCPILEI FYESDLPEAF
     AAFKALLVSG KLPPYALIEL VKKKYPALMP VIMIEISELS KISFFIIQDI ALNKEKYLNE
     NFDVNLACVL GMIKKRPERV VNILNRYGID SKDSLRSDVV QFIEKIKQFL HLEKKSIETE
     FDSIISLAKK NSKTNRGFIQ KFFLSPSEKK IEALKKNTLL KSIDFKDEVI QNIDLSCCSF
     FSVSLFFCKC NIRNCDFSRA SFFKAFFKKS LFYNVDMHET EFDRVNFDDT VFINVNAQNA
     TFKNCSFQNV SVFNCNFNCA DMTDASFLNA VISKTSFNRT KIAGACFAHS RISAVSFVDS
     NIEQADFSNV SARFCRFPSG AGLIVKTQDM DYNAREFQVS LNDMPKMDKT TVAQINILIF
     SEFIHYGEKK FLKQNQLSLL TAFDIFKTKQ ADLFQIIPFL LHEHIEFQGV SGISDKTPRG
     ICDYVPSFET QEVLKKYISI DNIPVRRCKN HAIEGLFTIG SIGSIAQTSE SDIDYWICIN
     EDNFTEKELD LLKKKLKTIE HLALYEFDTT VMFFLVDIIK TKHNDFGEST FESSGSAQTR
     LLKEEFYRTM IYVAGKIPLW SVLPTAISIN YYNTILNEIS NFSKFVRYMD LGDIHAISTN
     EYFGASIWQM FKWLKSPFKS VIKIALLEKY IYEYGKESLL CNKYKDEWMN SGIHLQLAQN
     DAYYILLKNL INYYQTAKDE YSVNLMLTCF FLKLGISKEE QIDNTVFGLR KILLEKCLIK
     WSWKKNKIFY IGGFKTWPYS DIVKLSNSIK KYMKKKHATV KTLFQGMFHD RSRISPEDRI
     VLERRVSIEF SKQPGKVDKI LLISQNDRHF QGLHLKYIKR NDTIGTWELF NKNKKSVYHN
     EESLIKAKTI EEIGAWLINN NLYKETAVVN LIPNPTYASF NDIRKLYKTM YDFFSPVYKK
     VITFDQLSEE KEVIYLFVSI NFYSPRQQQK ITEYTAVYLN SWGEIFCKSF YSDHGFSTME
     ETKKDLMNRI GLERLPENTV FYFSKGAVR
//