UniProt: K0P022

Database: UniProt
Entry: K0P022_9BACT

LinkDB:  K0P022_9BACT 
Original site:  K0P022_9BACT

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Ontology (3)   
   GO (3)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (7)   
   Pfam (3)   
   PROSITE (1)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (19)   

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ID   K0P022_9BACT            Unreviewed;       474 AA.
AC   K0P022;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=Magnesium transporter MgtE {ECO:0000256|RuleBase:RU362011};
GN   ORFNames=CAHE_0170 {ECO:0000313|EMBL:CCM09952.1};
OS   Cardinium endosymbiont cEper1 of Encarsia pergandiella.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Amoebophilaceae;
OC   Cardinium.
OX   NCBI_TaxID=1231626 {ECO:0000313|EMBL:CCM09952.1, ECO:0000313|Proteomes:UP000003996};
RN   [1] {ECO:0000313|EMBL:CCM09952.1, ECO:0000313|Proteomes:UP000003996}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zchori-Fein et al. 2004 {ECO:0000313|Proteomes:UP000003996};
RX   PubMed=23133394; DOI=10.1371/journal.pgen.1003012;
RA   Penz T., Schmitz-Esser S., Kelly S.E., Cass B.N., Muller A., Woyke T.,
RA   Malfatti S.A., Hunter M.S., Horn M.;
RT   "Comparative Genomics Suggests an Independent Origin of Cytoplasmic
RT   Incompatibility in Cardinium hertigii.";
RL   PLoS Genet. 8:e1003012-e1003012(2012).
CC   -!- FUNCTION: Acts as a magnesium transporter.
CC       {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362011};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362011}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC       {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU362011}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU362011}.
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DR   EMBL; HE983995; CCM09952.1; -; Genomic_DNA.
DR   AlphaFoldDB; K0P022; -.
DR   STRING; 1231626.CAHE_0170; -.
DR   KEGG; che:CAHE_0170; -.
DR   PATRIC; fig|1231626.3.peg.171; -.
DR   eggNOG; COG2239; Bacteria.
DR   HOGENOM; CLU_037408_2_2_10; -.
DR   Proteomes; UP000003996; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd04606; CBS_pair_Mg_transporter; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.25.60.10; MgtE N-terminal domain-like; 1.
DR   Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR   InterPro; IPR038076; MgtE_N_sf.
DR   InterPro; IPR006669; MgtE_transporter.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   NCBIfam; TIGR00400; mgtE; 1.
DR   PANTHER; PTHR43773; MAGNESIUM TRANSPORTER MGTE; 1.
DR   PANTHER; PTHR43773:SF1; MAGNESIUM TRANSPORTER MGTE; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01769; MgtE; 1.
DR   Pfam; PF03448; MgtE_N; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM00924; MgtE_N; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF161093; MgtE membrane domain-like; 1.
DR   SUPFAM; SSF158791; MgtE N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|RuleBase:RU362011};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362011};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362011};
KW   Metal-binding {ECO:0000256|RuleBase:RU362011};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362011}.
FT   TRANSMEM        300..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        405..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        450..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   DOMAIN          150..212
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          213..272
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   474 AA;  53710 MW;  A40F856276DC15BD CRC64;
     MVVPYGTKNE IMKLKGENKF FKWMRLLKQQ QEKRLVYCLE HASPIEVAEF LEKQAFDLVR
     TVFSNLSIPR QGEVFALFND NALQMQLYYS IPKSTFAKIF SCMPSDLRVD FYQRLSNKEH
     AHLLPYLSRK IREDVIMLNA YLPDTAGGIM NTDFATVLNS MTVEEAIDKI REDAPSKKML
     YYIYVVDEKM CLVGFVSLKD LVMHTPKEKI ETILKVNFVY ATVDEDQEVV AKKIEQYDLV
     AIPILNQEGQ IVGIVSYDDA IAIIRAEQVE DMDRFMGITS EEDTPGYLKV STLQHLKKRI
     KWIVLVFIAS MIGHAFTQAN SSFFSQFNLI FYLAMITETG GNVASQVASV VLQALNRGQV
     SLSDWVKIIL KELRIAITLA SLLFFLTCVK LFLASTLGFD ANRSFQVIFV VALSIVVQII
     CSAFIGAAFP LAAKYFNGDP SVAANPMINI TVDILGIMIY YVIIYWLIHP VGSM
//

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