ID   K0RRS9_THAOC            Unreviewed;       552 AA.
AC   K0RRS9;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Sulfhydryl oxidase {ECO:0000256|RuleBase:RU371123};
DE            EC=1.8.3.2 {ECO:0000256|RuleBase:RU371123};
DE   Flags: Fragment;
GN   ORFNames=THAOC_31739 {ECO:0000313|EMBL:EJK49387.1};
OS   Thalassiosira oceanica (Marine diatom).
OC   Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC   Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC   Thalassiosiraceae; Thalassiosira.
OX   NCBI_TaxID=159749 {ECO:0000313|EMBL:EJK49387.1, ECO:0000313|Proteomes:UP000266841};
RN   [1] {ECO:0000313|EMBL:EJK49387.1, ECO:0000313|Proteomes:UP000266841}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1005 {ECO:0000313|EMBL:EJK49387.1,
RC   ECO:0000313|Proteomes:UP000266841};
RX   PubMed=22835381; DOI=10.1186/gb-2012-13-7-r66;
RA   Lommer M., Specht M., Roy A.S., Kraemer L., Andreson R., Gutowska M.A.,
RA   Wolf J., Bergner S.V., Schilhabel M.B., Klostermeier U.C., Beiko R.G.,
RA   Rosenstiel P., Hippler M., Laroche J.;
RT   "Genome and low-iron response of an oceanic diatom adapted to chronic iron
RT   limitation.";
RL   Genome Biol. 13:R66-R66(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR';
CC         Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2;
CC         Evidence={ECO:0000256|RuleBase:RU371123};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974,
CC         ECO:0000256|RuleBase:RU371123};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJK49387.1}.
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DR   EMBL; AGNL01044848; EJK49387.1; -; Genomic_DNA.
DR   AlphaFoldDB; K0RRS9; -.
DR   EnsemblProtists; EJK49387; EJK49387; THAOC_31739.
DR   eggNOG; KOG1731; Eukaryota.
DR   OMA; QFHAVSC; -.
DR   Proteomes; UP000266841; Unassembled WGS sequence.
DR   GO; GO:0016971; F:flavin-dependent sulfhydryl oxidase activity; IEA:InterPro.
DR   Gene3D; 1.20.120.310; ERV/ALR sulfhydryl oxidase domain; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR036774; ERV/ALR_sulphydryl_oxid_sf.
DR   InterPro; IPR017905; ERV/ALR_sulphydryl_oxidase.
DR   InterPro; IPR039798; Sulfhydryl_oxidase.
DR   PANTHER; PTHR22897; QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE; 1.
DR   PANTHER; PTHR22897:SF8; SULFHYDRYL OXIDASE; 1.
DR   Pfam; PF04777; Evr1_Alr; 1.
DR   SUPFAM; SSF69000; FAD-dependent thiol oxidase; 1.
DR   PROSITE; PS51324; ERV_ALR; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU371123};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|RuleBase:RU371123};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU371123};
KW   Reference proteome {ECO:0000313|Proteomes:UP000266841}.
FT   DOMAIN          378..508
FT                   /note="ERV/ALR sulfhydryl oxidase"
FT                   /evidence="ECO:0000259|PROSITE:PS51324"
FT   REGION          27..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..57
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         552
FT                   /evidence="ECO:0000313|EMBL:EJK49387.1"
SQ   SEQUENCE   552 AA;  62220 MW;  D6D29EF1B7A821BA CRC64;
     MSGNPRPPKS LTSISTWPSC SAYATRTGVI GIRTPRTRRK RRTSRPEETE GGGDKKGWLA
     TLKEKATGGV KDEGGKTLVK LKSKRQAFLN LTSDAAHIVD TSGSTSGSRR RSFAGPRRSQ
     VCFVWVGVSK VYAHTTHRPL AVVQFHAVSC DVYHAICSTY DIDGFPTIFG WKHGESLESP
     GIALNDDGEP DADDVGELLE LDLAHEEKGL FNWTFETDED RESYEKDMIE QAKKAARTKK
     LWHETKPNTH NDRRVDGLSQ SARVGFAAGR GERYSVILWL RCASSNRALS SRNPQSWQLR
     TTFVKELQRR ISSDAIADRG VVESIIKTDM DRHRSGETED PWGYVDTTVR SKLVGKILGK
     PDPVQLAKDD KHWSKACTHS QPAKGFTCGL WNLFHILTIG ASKKDHEMYG FHRGFLVSQH
     HVAETIKNFI AYFFSCDVCR TNFLNMYDGC GHGHCDRLKQ EVLSVAGNDS DRMELALWLW
     EVHNSVNTRL MKEAATRQNR EITHEENFAA LFPTKRMCPG CWLDDDMTKW DNATVFDFLD
     GWYWPANSAP VD
//