ID K0S4K9_THAOC Unreviewed; 451 AA.
AC K0S4K9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=phosphoribosylaminoimidazole carboxylase {ECO:0000256|ARBA:ARBA00012329};
DE EC=4.1.1.21 {ECO:0000256|ARBA:ARBA00012329};
GN ORFNames=THAOC_19984 {ECO:0000313|EMBL:EJK59754.1};
OS Thalassiosira oceanica (Marine diatom).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=159749 {ECO:0000313|EMBL:EJK59754.1, ECO:0000313|Proteomes:UP000266841};
RN [1] {ECO:0000313|EMBL:EJK59754.1, ECO:0000313|Proteomes:UP000266841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1005 {ECO:0000313|EMBL:EJK59754.1,
RC ECO:0000313|Proteomes:UP000266841};
RX PubMed=22835381; DOI=10.1186/gb-2012-13-7-r66;
RA Lommer M., Specht M., Roy A.S., Kraemer L., Andreson R., Gutowska M.A.,
RA Wolf J., Bergner S.V., Schilhabel M.B., Klostermeier U.C., Beiko R.G.,
RA Rosenstiel P., Hippler M., Laroche J.;
RT "Genome and low-iron response of an oceanic diatom adapted to chronic iron
RT limitation.";
RL Genome Biol. 13:R66-R66(2012).
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-
CC phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00004747}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJK59754.1}.
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DR EMBL; AGNL01022387; EJK59754.1; -; Genomic_DNA.
DR AlphaFoldDB; K0S4K9; -.
DR EnsemblProtists; EJK59754; EJK59754; THAOC_19984.
DR eggNOG; ENOG502S0IG; Eukaryota.
DR UniPathway; UPA00074; UER00130.
DR Proteomes; UP000266841; Unassembled WGS sequence.
DR GO; GO:0043727; F:5-amino-4-imidazole carboxylate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR039476; P2CMN_synthase_LarB.
DR InterPro; IPR000031; PurE_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; NF033503; LarB; 1.
DR PANTHER; PTHR43064; PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR43064:SF1; SLL1489 PROTEIN; 1.
DR Pfam; PF00731; AIRC; 1.
DR SMART; SM01001; AIRC; 1.
DR SUPFAM; SSF52255; N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE); 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000266841}.
FT DOMAIN 248..382
FT /note="PurE"
FT /evidence="ECO:0000259|SMART:SM01001"
SQ SEQUENCE 451 AA; 48450 MW; CC24A687B575C88F CRC64;
MWETCPFCRT PTQFSDAAAL ALVQKRVDTM DPKATEYLAQ VNYKGRYGLE IDIPRTGDRI
MDGGSKSRRP GCSLLARILV LPYRGEGVEE DMTRGIRHLQ HVHEYSNGNH EVAVQHWMIS
AKMGYERSLN KIKGMFMKGH ATEAQHAEAL TGYQTALDEA RSPQREEAKA FFNKTALLVR
RQELATARCS TTAIIATRVD KETYEAVVSE GPLEGGTVEY HETARIISVK ADTVDDNRHV
IESSSGRPSV VVACAGTTDL PVAEEAALTL SLCGIRVERV NDCGVAGLHR IIGALPRLRD
PAVGCVIVCA GMDGALPSVV GGLVDVPTVA CPTSVGYGAS FNGVASLLTM LNSCSPGVSV
VNIDNGFGAA VFALKVVNAA AGTRRERGIP PDFLVESRRN DTPLIAPETP VPARDLSDDP
WVPLGLVKQT KTLTPLGAEC PLRVEGPMAS F
//
