ID K0T7D7_THAOC Unreviewed; 854 AA.
AC K0T7D7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EJK73550.1};
GN ORFNames=THAOC_04819 {ECO:0000313|EMBL:EJK73550.1};
OS Thalassiosira oceanica (Marine diatom).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=159749 {ECO:0000313|EMBL:EJK73550.1, ECO:0000313|Proteomes:UP000266841};
RN [1] {ECO:0000313|EMBL:EJK73550.1, ECO:0000313|Proteomes:UP000266841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1005 {ECO:0000313|EMBL:EJK73550.1,
RC ECO:0000313|Proteomes:UP000266841};
RX PubMed=22835381; DOI=10.1186/gb-2012-13-7-r66;
RA Lommer M., Specht M., Roy A.S., Kraemer L., Andreson R., Gutowska M.A.,
RA Wolf J., Bergner S.V., Schilhabel M.B., Klostermeier U.C., Beiko R.G.,
RA Rosenstiel P., Hippler M., Laroche J.;
RT "Genome and low-iron response of an oceanic diatom adapted to chronic iron
RT limitation.";
RL Genome Biol. 13:R66-R66(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. CDPK subfamily. {ECO:0000256|ARBA:ARBA00024334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJK73550.1}.
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DR EMBL; AGNL01004410; EJK73550.1; -; Genomic_DNA.
DR AlphaFoldDB; K0T7D7; -.
DR EnsemblProtists; EJK73550; EJK73550; THAOC_04819.
DR eggNOG; KOG0032; Eukaryota.
DR OMA; VHARCAN; -.
DR Proteomes; UP000266841; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR24349:SF507; -; 1.
DR PANTHER; PTHR24349; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000266841}.
FT DOMAIN 137..431
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 545..632
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 648..765
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 785..814
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 815..850
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT BINDING 171
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 854 AA; 95135 MW; 3D89D79255E577EA CRC64;
MSPRLSTLAR TWTSKNAAWG TVAAAAAAAA ALAAWHPREV GDGDSGDAGD ALTCNLLVDE
RGKVTSPDRG PSHDSLLLRI LGASQTSTNR HACHCESSGL KNEDKEIKRA NIQRSRTIRI
LSSKATQNRK LSDVYDVNFD TPLGEGAFGK VLLVSHKQTG ERVAMKRIPK KLASREDFQR
EMEALLRIQK WGGHPHICAL HEHFDEGGYY YLILDLVEGG EMFDHLVNHG AYSEADAARL
VREVASALDF LHGIGVEEQV HNDVKPENLM LSSTAQRCGS IQLVDFGCAE VEGEDDDDDD
HLDLDDIFSR KRGAKGSNKH VGQGGFTPAY SSPEAFEDRN AAPLPPSDMW ALGVIVYIML
TGVHPFDIQG RATDEDIERE VRNCDAPLPL GPKHPFTRHL SPSARDLIAS LMERDPKKRL
SAFEMLHHPW VTGETASTNI MIGSDQKLNR FRKFKTRLQT QFFADAVGWS DEAIAEETRR
RTSLIERSFH AFDGSDLKMR KLLSNRKHGL LASELGLGLD NEPRNEVQEV DNRAEMTMSD
YQDLLSENMK QKYFPKGHVI YNEGDTGRSM YFINSGTVIV STSDGIKNKR HSGDFFGEGA
LLHPKGKHSA TITCKTPVHV IEISREYFEQ YMAEDTGVVL SLREKQKIRK RNRAKALLKL
QSGMKTKKAA FGEVIYSEGD EGDSLYLVEK GKIDLTSGGH NVLVATEGNF CGEHSLLTGR
LRNTTATCIN EEGCILERMS GYDFRKLMEA SPLVRESLVD LMNRRDFKKA MVLKLGESFP
YGNPRKAFDA VDVGKKGYLD YQDIATLMRL LDKKYTDDEC SNVFETIDLS KDGKVTYNEF
AKVFIGDIRA TASM
//
