ID K0TK71_THAOC Unreviewed; 1176 AA.
AC K0TK71;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=THAOC_07553 {ECO:0000313|EMBL:EJK71042.1};
OS Thalassiosira oceanica (Marine diatom).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=159749 {ECO:0000313|EMBL:EJK71042.1, ECO:0000313|Proteomes:UP000266841};
RN [1] {ECO:0000313|EMBL:EJK71042.1, ECO:0000313|Proteomes:UP000266841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1005 {ECO:0000313|EMBL:EJK71042.1,
RC ECO:0000313|Proteomes:UP000266841};
RX PubMed=22835381; DOI=10.1186/gb-2012-13-7-r66;
RA Lommer M., Specht M., Roy A.S., Kraemer L., Andreson R., Gutowska M.A.,
RA Wolf J., Bergner S.V., Schilhabel M.B., Klostermeier U.C., Beiko R.G.,
RA Rosenstiel P., Hippler M., Laroche J.;
RT "Genome and low-iron response of an oceanic diatom adapted to chronic iron
RT limitation.";
RL Genome Biol. 13:R66-R66(2012).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJK71042.1}.
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DR EMBL; AGNL01007720; EJK71042.1; -; Genomic_DNA.
DR AlphaFoldDB; K0TK71; -.
DR EnsemblProtists; EJK71042; EJK71042; THAOC_07553.
DR eggNOG; ENOG502TJ6H; Eukaryota.
DR Proteomes; UP000266841; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF14500; MMS19_N; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000266841}.
FT DOMAIN 321..417
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT REGION 235..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1176 AA; 127827 MW; 110B1498E65805F9 CRC64;
MSSTEGEDPG EVFKRWLSVC AVGGDRSDTL PELRGEASSH FKALSEASAS LSLTATVQQD
VLAASFTTAN GSLASLLKTL GPVFSSSDNT SKIRALHYIA GAIEGSTKLT HGIRMAMAQF
VVEICKPEEG GGKIREDFVD GGEGLSPKEL TAKLEAMERQ QIEDSSNDET TPFDEVRDAA
MVTLEALLES NLDVFPTQLS SHSSGKPRNE ALAVIYESIQ LRADVAVRCI NSRCASPSKD
KDDTWSSNGG DGYHPEHYNP NIEDGLSQLP RVKRSLCFEL LEGALRGIHD DILKWKKLTL
QKNQLTNDDY FESIPDNALN SLISYASTSA SCLYGETDPR CLLQLLLHLN RVQQVMLPFF
GTSDSRAETT LFPSVVIFDS VAPYYPIRFT PPKNDPHGIT REKLQAALLA VLCEKNAVYE
PNASMLDGET MVSLSARMFM ERLEPSEDMD YEPPSDGAQS EADDKIDAVN DLTSLLIPID
ETNFSNLGLV DSSLLRDLSF TLARVHEKSA HSTLNDLARR TRNLGSAISS CLDQRSTRST
CILDRAPRFE AFVSDLIRHL SPVLGTAPQG THGRASTAYM STLAAEGGLT TLNCVLQACY
PRLLGVSALA KTASQSSRDN EKVAAALRGI AALMSSCRVA LKKWEDRNGG AKVHPHPLES
FSADTIRIIS FVAIQKSSTS LKIAANGALE SFVTAVDTNA LESDDLDLLS ETLSATFDNV
LGDNKLVEND LRTASARAIS GVIAIGFDED KDNKSVGVLA SSFLPKVIQS ATRPSKRRPR
FDWIILSGAC ANGPKSVSRR IVSQLLTLAV EDTSGVTVFK LLSYLVRHSP GPTLGEMVHC
RSLSDPSLFD VIRMLSSDRC SQETEPLSRQ LSVGPSALRL PKSPAPQVED TDRNVSIFSP
KKTVPVTLNL FLFQKRIREL LPYLTRLFEC PAAQLSCSLL VNQVDQVIPP LSASDNLELR
VVLPLLSTVL NAPNMNWTIL DETTTRALDS MTSFFTQFSL SHEHDVDVKS AAASCLFSIL
VNSKLEEDRP LALFRDEISG ILAAAFNDNS TSSSSLSDDS MMENALNMTA LLVSFRPPNS
RPGEYLTNVL QASAAACRGG ASSRTADRAT LFLAELACTG KSICPFSEVP ILLRQLDGPS
QRRPLQTSSF TAYVLSASAY SEVISVQNGT PFWRQR
//
