ID K0UL16_MYCVA Unreviewed; 536 AA.
AC K0UL16;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Putative adenylate/guanylate cyclase {ECO:0000313|EMBL:EJZ07446.1};
GN ORFNames=MVAC_18865 {ECO:0000313|EMBL:EJZ07446.1};
OS Mycolicibacterium vaccae ATCC 25954.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1194972 {ECO:0000313|EMBL:EJZ07446.1, ECO:0000313|Proteomes:UP000006072};
RN [1] {ECO:0000313|EMBL:EJZ07446.1, ECO:0000313|Proteomes:UP000006072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25954 {ECO:0000313|EMBL:EJZ07446.1,
RC ECO:0000313|Proteomes:UP000006072};
RX PubMed=23105074; DOI=10.1128/JB.01462-12;
RA Ho Y.S., Adroub S.A., Abadi M., Al Alwan B., Alkhateeb R., Gao G.,
RA Ragab A., Ali S., van Soolingen D., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954.";
RL J. Bacteriol. 194:6339-6340(2012).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ07446.1}.
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DR EMBL; ALQA01000043; EJZ07446.1; -; Genomic_DNA.
DR RefSeq; WP_003933453.1; NZ_JH814702.1.
DR AlphaFoldDB; K0UL16; -.
DR PATRIC; fig|1194972.3.peg.3759; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG3850; Bacteria.
DR HOGENOM; CLU_025433_2_1_11; -.
DR Proteomes; UP000006072; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 51..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 276..328
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 360..484
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 536 AA; 58304 MW; 4E4EF294B8AA21E0 CRC64;
MNATKSVPYR LGRVLERVTR QSGRLGTPDY GSWLLGKPEE SQARRRIRIQ VILTVFILLT
NILGIAVSLL LNTVAIPVPS VFSDAPAWLT FGVTPAFMVL ALILGTAWIT SRTVGSLRWA
IEERRPTGAD QRNVFLAPAR VAQKLLFLWG VGTFLLTLLY GLQDTAFIPR FLFAVGFPGI
VVATACYMIT EFALRPIAAQ ALEAGRPPRR LAHGVMGRTM TVWLLSSGVP VLGILLLAVF
SLSLKNLSST QFAVAVMIIA IVALVFGLVL MWLLSWLIAT PVRVVRSALK QVEEGDLDCN
LVVFDGTELG ELQRGFNSMV HGLRERERVR DLFGRHVGRE VALAAEKQRI ELGGEERHAA
VIFIDIIGST QLVTSRPAVE VVELLNRFFD VVVEEVDNHH GLVNKFEGDA VLAVFGAPVS
LDNAETEALS AARAMARRLR EEIPELRAGI GVAAGQVVAG NVGAKERFEY TVIGEPVNEA
ARLCELAKNE PHLVVAAADT VAGATEDERA RWQLGETVTL RGHDQPTQLA TPAGGL
//
