ID K0VLT5_MYCVA Unreviewed; 346 AA.
AC K0VLT5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=MVAC_04071 {ECO:0000313|EMBL:EJZ12084.1};
OS Mycolicibacterium vaccae ATCC 25954.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1194972 {ECO:0000313|EMBL:EJZ12084.1, ECO:0000313|Proteomes:UP000006072};
RN [1] {ECO:0000313|EMBL:EJZ12084.1, ECO:0000313|Proteomes:UP000006072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25954 {ECO:0000313|EMBL:EJZ12084.1,
RC ECO:0000313|Proteomes:UP000006072};
RX PubMed=23105074; DOI=10.1128/JB.01462-12;
RA Ho Y.S., Adroub S.A., Abadi M., Al Alwan B., Alkhateeb R., Gao G.,
RA Ragab A., Ali S., van Soolingen D., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954.";
RL J. Bacteriol. 194:6339-6340(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ12084.1}.
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DR EMBL; ALQA01000005; EJZ12084.1; -; Genomic_DNA.
DR RefSeq; WP_003930007.1; NZ_JH814688.1.
DR AlphaFoldDB; K0VLT5; -.
DR PATRIC; fig|1194972.3.peg.822; -.
DR eggNOG; COG1024; Bacteria.
DR HOGENOM; CLU_009834_22_1_11; -.
DR Proteomes; UP000006072; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EJZ12084.1}.
FT DOMAIN 16..334
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 346 AA; 36518 MW; 953A00DFF2D078CC CRC64;
MDENKDVLVT AAGGLGRITL NRPKAINSLT HPMVETIART LTAWETDDAV DAVVVSGAGD
RGLCAGGDVV AIYHDAKTGG SGSRRFWHDE YLLNAYIGRY PKPYVAVMNG ITMGGGVGIS
AHGSVRVVTE TTKMAMPEVG IGFIPDVGGT YILSRTPGLL GVHAALTGAP FSGADAIAMG
FADHFVPQDR LESFVDAIEA DGVDAAVAAF AQEPPASALL AQREWIDHCY AQETVADIVA
ALRDHGGAAA EAADLIASRS PVAVSVTLEA VRRAAKLDTL EDVLRQEFRI SCASLRSHDL
VEGIRAQLID KDRNPKWSPA SLSQVTSADV EAYFASADPD LTFDEE
//
