ID K0YHG5_9CORY Unreviewed; 651 AA.
AC K0YHG5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
DE Flags: Fragment;
GN ORFNames=HMPREF9719_00103 {ECO:0000313|EMBL:EJZ82992.1};
OS Corynebacterium otitidis ATCC 51513.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=883169 {ECO:0000313|EMBL:EJZ82992.1, ECO:0000313|Proteomes:UP000006078};
RN [1] {ECO:0000313|EMBL:EJZ82992.1, ECO:0000313|Proteomes:UP000006078}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51513 {ECO:0000313|EMBL:EJZ82992.1,
RC ECO:0000313|Proteomes:UP000006078};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Turicella otitidis ATCC 51513.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|RuleBase:RU000644}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ82992.1}.
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DR EMBL; AHAE01000005; EJZ82992.1; -; Genomic_DNA.
DR RefSeq; WP_004599993.1; NZ_JH815192.1.
DR AlphaFoldDB; K0YHG5; -.
DR STRING; 29321.AAV33_08140; -.
DR PATRIC; fig|883169.3.peg.98; -.
DR eggNOG; COG0532; Bacteria.
DR HOGENOM; CLU_006301_5_1_11; -.
DR OrthoDB; 9811804at2; -.
DR Proteomes; UP000006078; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR CDD; cd03702; IF2_mtIF2_II; 1.
DR CDD; cd03692; mtIF2_IVc; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR HAMAP; MF_00100_B; IF_2_B; 1.
DR InterPro; IPR044145; IF2_II.
DR InterPro; IPR006847; IF2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00487; IF-2; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR Pfam; PF04760; IF2_N; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|RuleBase:RU000644};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU000644};
KW Reference proteome {ECO:0000313|Proteomes:UP000006078}.
FT DOMAIN 142..319
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EJZ82992.1"
SQ SEQUENCE 651 AA; 70325 MW; 49E192C336835073 CRC64;
RGGRRGGTAG AFGRPGGPPR KRRKSKRQKR HEYEAMKAPN VVGGVHLPDG GGKTIRLRQG
ASLADFAEKI GTDASNLVQA LFNLGEMVTA TASVSEDTLK LLGDEINYKV QVVSPEDEDR
ELLESFNLQF GESEGDEDDL ETRAPVVSVM GHVDHGKTRL LDAIRHANVA AREAGGITQG
IGAYQVSVNP SHSDDEDDER KITFLDTPGH EAFTAMRARG AKSTDIAILV VAADDGVMPQ
TVEAINHAKA ADVPIVVAVN KIDKPEAQPE KIRGQLTEYG LVPEEYGGDT LFVDISARNG
DNIDELLEAV LLTADASLEL EANPDMDAQG LAIEAHLDRG RGPVATVLVQ RGTLRVGDSI
VVGDAFGRVR RMLDEYGEDV EEAEPSRPVQ VQGLNSVPGA GDNLLVVDDD RVARQIANQR
DARRRSAMQA KNRKRVSLED LDEVLKEHST LNIILKGDNA GSVEALEDAL LGIEIDDEVQ
LDIIDRGVGA VTQTNVSLAA ASDAIIIAFN VRSEGKATEE ANQEGVEIRY YTVIYEAIEE
VESALKGMLK PVYKESEVGT AEIRQIFKSS AVGLIAGCKV EDGKVVRNAK ARLVRDGNVI
AEKASIESLR REKDDVTEVS AGYECGMVLS YPDIQVGDEI QVYEMVEVPR D
//
