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Database: UniProt
Entry: K0ZJ08_9ACTO
LinkDB: K0ZJ08_9ACTO
Original site: K0ZJ08_9ACTO 
ID   K0ZJ08_9ACTO            Unreviewed;       534 AA.
AC   K0ZJ08;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   07-OCT-2020, entry version 54.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|ARBA:ARBA00018893, ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF9241_00388 {ECO:0000313|EMBL:EJZ87760.1};
OS   Schaalia turicensis ACS-279-V-Col4.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae; Schaalia.
OX   NCBI_TaxID=883077 {ECO:0000313|EMBL:EJZ87760.1, ECO:0000313|Proteomes:UP000003994};
RN   [1] {ECO:0000313|EMBL:EJZ87760.1, ECO:0000313|Proteomes:UP000003994}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACS-279-V-Col4 {ECO:0000313|EMBL:EJZ87760.1,
RC   ECO:0000313|Proteomes:UP000003994};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Saerens B., Vaneechoutte M.,
RA   Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Larimer J., McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Actinomyces turicensis ACS-279-V-COL4.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC       ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU004227}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJZ87760.1}.
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DR   EMBL; AGWQ01000003; EJZ87760.1; -; Genomic_DNA.
DR   RefSeq; WP_006680594.1; NZ_JH815208.1.
DR   STRING; 883077.HMPREF9241_00388; -.
DR   EnsemblBacteria; EJZ87760; EJZ87760; HMPREF9241_00388.
DR   PATRIC; fig|883077.3.peg.380; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_2_0_11; -.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000003994; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00377};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW   Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003994}.
FT   DOMAIN          220..357
FT                   /note="AAA"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          437..505
FT                   /note="Bac_DnaA_C"
FT                   /evidence="ECO:0000259|SMART:SM00760"
FT   NP_BIND         228..235
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00377"
FT   REGION          87..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..102
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..133
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   534 AA;  60070 MW;  2AEB7EDA2349A1A7 CRC64;
     METPSLNAAW TQALELLAQT GLGPAGMGFL QSTRPLGNIE GTILLSVPND FTKNWIERSS
     SSVTDALSQT FGKRTRIAIT VDPDMELPET ADEKEHQAKN VEVASSTEDN QPTTNEVPSA
     GHHQTGDTPT YAQSFSYPSA EERLRQLDGV EAINDFPDSS FEEHDPKRFS YVAPQSTDRA
     LDTSSTRLNP KHTFDTFVIG PSNRFAHAAA VAVSESPGTD FNPLFIYGES GLGKTHLLQA
     IGHYTLSLYP NQKVRYVSSE EFTNEFINAI RVNNPNNSAV EEFHRRYREL DLLLIDDIQF
     LSKKEQTMEG FFHTFNALYQ ANKQIVITSD VQPKHLEGIE ERLRSRFGSG LLVDVQPPDL
     ETRIAILQKK TADENLDIDP EIFTYIAERI SSNIRELEGA ILRVVAYANL YHEKIDLALA
     EMTLKDYISD PDDTEITIPL IMGQCAKYFN VTIDQLCSTD RSRAIVEARQ IAMYLCRELT
     ELSLPKIGQS FDRDHSTVMH ANKKILEQMK QRREVYNDVT ELTNRIKKVA RGGN
//
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