ID K0ZKD7_9ACTO Unreviewed; 655 AA.
AC K0ZKD7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DNA-directed DNA polymerase family A palm domain-containing protein {ECO:0000259|SMART:SM00482};
GN ORFNames=HMPREF9241_00161 {ECO:0000313|EMBL:EJZ88300.1};
OS Schaalia turicensis ACS-279-V-Col4.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Schaalia.
OX NCBI_TaxID=883077 {ECO:0000313|EMBL:EJZ88300.1, ECO:0000313|Proteomes:UP000003994};
RN [1] {ECO:0000313|EMBL:EJZ88300.1, ECO:0000313|Proteomes:UP000003994}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACS-279-V-Col4 {ECO:0000313|EMBL:EJZ88300.1,
RC ECO:0000313|Proteomes:UP000003994};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Saerens B., Vaneechoutte M.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Larimer J., McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Actinomyces turicensis ACS-279-V-COL4.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ88300.1}.
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DR EMBL; AGWQ01000002; EJZ88300.1; -; Genomic_DNA.
DR RefSeq; WP_006680367.1; NZ_JH815208.1.
DR AlphaFoldDB; K0ZKD7; -.
DR STRING; 883077.HMPREF9241_00161; -.
DR PATRIC; fig|883077.3.peg.154; -.
DR eggNOG; COG0749; Bacteria.
DR HOGENOM; CLU_012044_0_0_11; -.
DR Proteomes; UP000003994; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08642; DNA_pol_A_pol_I_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000003994}.
FT DOMAIN 375..619
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 655 AA; 71640 MW; 75577F8395D9A1E6 CRC64;
MRSLACDLET YSPVNLTKSG VYPYATDPEF ELLLFGYSID SGDVHVIDLA SGQQLPDELL
AALVDPGVVK WAHNAAFERV AFSAWLRRHH PDLLAEEFLD PAQWRCTMVW AAYLGLPMSL
DAVGTALDLD VKKDSAGKKL IKQFCTPATP SVLNGGGTRN LPASDPTGWA QFVDYNRRDV
EVELAIHDRL SPFPMPEAEW DAYALDQTIN DTGILLDRTL ADAAVALDGQ HSTATLVRAR
ELTGLENPNS PIQLKDWLTT NGCKMSSLAK AEVAAALETA TGVVREVLEL RGDLAKSSVK
KYQAMHNVAG SDGRARGLIQ FYGAGRTGRF AGRLVQVQNL PRNYLPDLDA ARTLTRQGNL
DALELLYDSV PDTLSQLIRT AFIPSEGCRL IVADYSAIEA RVIAWLARET STLRAFRDGK
DLYCETASRM FGVPVEKHGV NAELRQKGKI ATLACGYNGS VGALKAMGAL RMGLAEHELK
PTVDAWRAAN PNIVQLWADV EQAALDAITT RSTLRLRNLC FSVESGILFI TLPSGRRLAY
VQPRLGENRW GGTSITYSGV TTGRKWGRLE TYGGKLVENI VQAVARDLLV HAMQLVAEAG
HRIVMHVHDE IVIDEPQDSV FTVADACALM ATLPAWADGL PLNADGYECD YYQKD
//
