UniProt: K1E055

Database: UniProt
Entry: K1E055_9MICO

LinkDB:  K1E055_9MICO 
Original site:  K1E055_9MICO

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (4)   
   InterPro (3)   
   Pfam (1)   
Literature (2)   
   PubMed (2)   
All databases (13)   

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ID   K1E055_9MICO            Unreviewed;       284 AA.
AC   K1E055;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Pyridoxal kinase PdxY {ECO:0000313|EMBL:RWU85063.1};
DE   SubName: Full=Pyridoxamine kinase {ECO:0000313|EMBL:EKA62220.1};
DE            EC=2.7.1.35 {ECO:0000313|EMBL:EKA62220.1};
GN   ORFNames=B277_03310 {ECO:0000313|EMBL:EKA62220.1}, CWN80_02605
GN   {ECO:0000313|EMBL:RWU85063.1};
OS   Janibacter hoylei PVAS-1.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC   Janibacter.
OX   NCBI_TaxID=1210046 {ECO:0000313|EMBL:EKA62220.1, ECO:0000313|Proteomes:UP000004474};
RN   [1] {ECO:0000313|EMBL:RWU85063.1, ECO:0000313|Proteomes:UP000288711}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PVAS-1 {ECO:0000313|EMBL:RWU85063.1,
RC   ECO:0000313|Proteomes:UP000288711};
RX   PubMed=19643890; DOI=10.1099/ijs.0.002527-0;
RA   Shivaji S., Chaturvedi P., Begum Z., Pindi P.K., Manorama R.,
RA   Padmanaban D.A., Shouche Y.S., Pawar S., Vaishampayan P., Dutt C.B.,
RA   Datta G.N., Manchanda R.K., Rao U.R., Bhargava P.M., Narlikar J.V.;
RT   "Janibacter hoylei sp. nov., Bacillus isronensis sp. nov. and Bacillus
RT   aryabhattai sp. nov., isolated from cryotubes used for collecting air from
RT   the upper atmosphere.";
RL   Int. J. Syst. Evol. Microbiol. 59:2977-2986(2009).
RN   [2] {ECO:0000313|EMBL:EKA62220.1, ECO:0000313|Proteomes:UP000004474}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PVAS-1 {ECO:0000313|EMBL:EKA62220.1,
RC   ECO:0000313|Proteomes:UP000004474};
RX   PubMed=23144385; DOI=10.1128/JB.01728-12;
RA   Pawar S.P., Dhotre D.P., Shetty S.A., Chowdhury S.P., Chaudhari B.L.,
RA   Shouche Y.S.;
RT   "Genome Sequence of Janibacter hoylei MTCC8307, Isolated from the
RT   Stratospheric Air.";
RL   J. Bacteriol. 194:6629-6630(2012).
RN   [3] {ECO:0000313|EMBL:RWU85063.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PVAS-1 {ECO:0000313|EMBL:RWU85063.1};
RA   Seuylemezian A., Cooper K., Vaishampayan P.;
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-
CC         amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP;
CC         Xref=Rhea:RHEA:19893, ChEBI:CHEBI:30616, ChEBI:CHEBI:57841,
CC         ChEBI:CHEBI:58354, ChEBI:CHEBI:456216; EC=2.7.4.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00000565};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-
CC         methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+);
CC         Xref=Rhea:RHEA:23096, ChEBI:CHEBI:15378, ChEBI:CHEBI:16892,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58354, ChEBI:CHEBI:456216;
CC         EC=2.7.1.49; Evidence={ECO:0000256|ARBA:ARBA00000151};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKA62220.1}.
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DR   EMBL; ALWX01000013; EKA62220.1; -; Genomic_DNA.
DR   EMBL; PIPF01000002; RWU85063.1; -; Genomic_DNA.
DR   RefSeq; WP_007925080.1; NZ_PIPF01000002.1.
DR   AlphaFoldDB; K1E055; -.
DR   STRING; 1210046.B277_03310; -.
DR   PATRIC; fig|1210046.3.peg.638; -.
DR   eggNOG; COG2240; Bacteria.
DR   OrthoDB; 9800808at2; -.
DR   Proteomes; UP000004474; Unassembled WGS sequence.
DR   Proteomes; UP000288711; Unassembled WGS sequence.
DR   GO; GO:0008478; F:pyridoxal kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009443; P:pyridoxal 5'-phosphate salvage; IEA:InterPro.
DR   CDD; cd01173; pyridoxal_pyridoxamine_kinase; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR013749; PM/HMP-P_kinase-1.
DR   InterPro; IPR004625; PyrdxlKinase.
DR   InterPro; IPR029056; Ribokinase-like.
DR   NCBIfam; TIGR00687; pyridox_kin; 1.
DR   PANTHER; PTHR10534; PYRIDOXAL KINASE; 1.
DR   PANTHER; PTHR10534:SF2; PYRIDOXAL KINASE; 1.
DR   Pfam; PF08543; Phos_pyr_kin; 1.
DR   SUPFAM; SSF53613; Ribokinase-like; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:EKA62220.1};
KW   Transferase {ECO:0000313|EMBL:EKA62220.1}.
FT   DOMAIN          92..252
FT                   /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT                   /evidence="ECO:0000259|Pfam:PF08543"
SQ   SEQUENCE   284 AA;  30682 MW;  E2B598C9599A2D98 CRC64;
     MTTILSIQSH VAYGHVGNSA SVFPMQRLGV EVWPVHTVNF SNHTGYGAWR GPLMDPADVA
     DVVTGIGERE AFAEIDAVLS GYQGGEGIGA TILDAVAAVK AVNPAAIYAC DPVMGNAKSG
     CFVHESIPVL LREKVVPQAD LITPNQFELG FLTDTEPQTL EETLASVDAA REIGPSTVLV
     TSVLRPDRPE GTIEMLACHD DEAWIVRTPH LPLKANGSGD VTAALFTSHW LRTQSLQESL
     GRTVSSVFDL LQLTLDSGRR ELQLVQAQEA YAHPRMQFEV TRVR
//

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