ID K1LUW1_9LACT Unreviewed; 770 AA.
AC K1LUW1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN ORFNames=HMPREF9707_01531 {ECO:0000313|EMBL:EKB53778.1};
OS Falseniella ignava CCUG 37419.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Falseniella.
OX NCBI_TaxID=883112 {ECO:0000313|EMBL:EKB53778.1, ECO:0000313|Proteomes:UP000005147};
RN [1] {ECO:0000313|EMBL:EKB53778.1, ECO:0000313|Proteomes:UP000005147}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 37419 {ECO:0000313|EMBL:EKB53778.1,
RC ECO:0000313|Proteomes:UP000005147};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Facklamia ignava CCUG 37419.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKB53778.1}.
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DR EMBL; AGZE01000037; EKB53778.1; -; Genomic_DNA.
DR RefSeq; WP_006702164.1; NZ_JH932301.1.
DR AlphaFoldDB; K1LUW1; -.
DR STRING; 883112.HMPREF9707_01531; -.
DR PATRIC; fig|883112.3.peg.1528; -.
DR eggNOG; COG0557; Bacteria.
DR HOGENOM; CLU_002333_4_1_9; -.
DR Proteomes; UP000005147; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013223; RNase_B_OB_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF08206; OB_RNB; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 4.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW Reference proteome {ECO:0000313|Proteomes:UP000005147};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 638..718
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 729..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..770
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 88458 MW; 9041A8B0A17F4D91 CRC64;
MSLTKKEQRI LKFLQDHQEH SYSVQELAGI FNYQGNKTYK KLVKALAYLE RIGEIEFLAN
GRVRAFGQLQ TTLTGIYRAN DKGYGFVDYE GDSDLFIPPG YALNAMDQDK VEVTVLKQVN
PMTGKGSEAR VERIIERHYQ QLVGEFYAYS NEEQVETGYL GYVIPQGTSG QAYTVFILPE
GIEPVDHSIV IVKIRDYPTN ENPSTLTGYV AKEIGHRDEP GVDILAILYQ LNIPHEFPQN
VLEEAEKFGL EINPEDVNGR VDHRNQLVMT IDGADAKDLD DAIALDQLAN GNYRLYVHIA
DVSHYVREGS PIDREAFERG TSVYLTDRVV PMLPQRLSNG ICSLHPGVDR LTLTCAMEID
AQGSVVDYQI YPAVINSSYR MTYEAINAIY NGDKALIEEY DPIISTLYSM RDLHHILEAK
RHRRGAINFD TTEAIIEVDD QGHPISIKAR ERGVGERLIE SFMLVANETV AQSYHEKELP
MIYRVHEQPD ADRMLKFAEL LTGFGIILQG HVESIQPKQL QRVMQKLKDS PYEEVVSMML
LRSMQQAHYS EESLGHYGLA AKYYTHFTSP IRRYPDLIVH RLVHQYLIKR PNQAEIDRLE
QRLPEIAVQS SKRERRSVEA ERETDALKKA EYMQDKIGEE FEGMISSITS FGIFVQLPNT
VEGLVHLNKL NDDYYQYYPE QWVLIGKERG KVYRIGQSVR IVVDQVNIEE REIDFNIIDA
ENAETDDLSH LIKRESSSKK KRKSRNQSHP VRQRKNTKAK KHSPKRRRRK
//
