ID K1PAK8_CRAGI Unreviewed; 812 AA.
AC K1PAK8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=CGI_10012366 {ECO:0000313|EMBL:EKC18468.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC18468.1};
RN [1] {ECO:0000313|EMBL:EKC18468.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC18468.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
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DR EMBL; JH817765; EKC18468.1; -; Genomic_DNA.
DR AlphaFoldDB; K1PAK8; -.
DR HOGENOM; CLU_002173_5_0_1; -.
DR InParanoid; K1PAK8; -.
DR OMA; FSSFKCE; -.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 473..812
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
SQ SEQUENCE 812 AA; 92276 MW; 83FEFDC264057AEA CRC64;
MAATDCMESS NLITCPTCDH SMSQNRGNKR IICPKCGNFY DRDSAVDELR QIRRVNREKQ
SPNEIKDRDE DKDKSGGTLS SIANFFQNLG PNRKTKPAGP QSRSNSQASS NLSEPSTKTP
NTELPPINHS QTPSGKRTPS YNVNGPHSPR PAEKDKPTAT KGDNTRVNTW AQQADSSISQ
ITASANNNKL VYPVRTKTAE QLKEDVLLAK ESKNWKVVQD FYATTFESFL EINAIFKPQE
IQKVVLKSVI NSLLKDKRPH TKDDLRAYLV LLQNPQFENF TTYVIFAHLL RQIAALTDQD
HHFLVHWMKG LKKQVFQRII KRLHNFISVR LFPPKPQDLP PMAKCTWWIP SATKVLALLN
AANNLTSPTI VQYSEFYNPT LDHLDLMAEY YTWQNPSSCA GFSFCQYPFI LSINAKRNIL
QRDSEQQMII MARRSLVAKV QRRQMPDVGM LFLNLTVRRS HLVSDSLNEI ARKQHDLKKK
LKVTFAGEPG LDMGGLTKEW FLLLIRQIFH SDYGMFTYDK RAGVHWFSSA HCESYQEFNL
VGVLMGLAVY NSIILDIHFP ACCFKKLLSP AVVPYNNPQA MVGMTTMNIN DLKTVQPDVA
NGLQNLLDYD GDVEDDFGLS FQVSVTEFGV MKTVDLKPNG SNIPVTNENR KEYMQLYVDW
ILNKSIYHQF QAFYHGFHSV CASNALIMLR PQEVEMLVCG NPILDMNELR KVTTYDGYSP
QDQVIKNFWD VVLSLPNELQ KRLLLFTTGS DRIPVGGMSE MTFKISRVGG TDLLPMSHTC
FNMLVLPAYK NKKTMRVKLI HAVQNAEGFG LE
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