ID   K1PI66_CRAGI            Unreviewed;       698 AA.
AC   K1PI66;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Putative tyrosinase-like protein tyr-3 {ECO:0000313|EMBL:EKC18549.1};
GN   ORFNames=CGI_10011913 {ECO:0000313|EMBL:EKC18549.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC18549.1};
RN   [1] {ECO:0000313|EMBL:EKC18549.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC18549.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA   Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JH823223; EKC18549.1; -; Genomic_DNA.
DR   AlphaFoldDB; K1PI66; -.
DR   HOGENOM; CLU_012415_1_0_1; -.
DR   InParanoid; K1PI66; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   4: Predicted;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          305..316
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   698 AA;  78059 MW;  611B74690607F96B CRC64;
     MPGLLFVSLC VGFLGLSLAL LEPIPFPASL QECYEYRSYN MTPSFEAAHQ IQQYCYRNFE
     YQQIASGKVW SGTNITIQGI NYIDSLFRQI FREVEEMERQ NKNGRRTKRQ TIGRRYRREV
     RSPGAYQPFA DCIVRLQNQF VEDPSTGRNT YQTLAAFHSG QALRTAHGGP GFAPWHRIYL
     LLLETACGAP IPYWESGLDH DMEDPTASIL WSDDFFGNGN GVVTTGPFRS MRTILGGPII
     RNYGTGEGAL FTKTGYNAVL SRTRYDDISE PKQGAAYFFT LEGHHNGPHT WTGGHLARPN
     SAPYDPVFYM HHSYVDAVYE AFRQRQRQNG INPETDYPVN TPPGHGFDDL IDFRPYINQI
     TNRYAMSDAV ANLVTYEPFA NCRNRCNGSP HLYCQNGVCV SRNRPTAAPS GTFAFGDSDG
     AFRRNQERMR FAEAAGPIPA GEKFRTAPLR DIRNQEDRLG IAPVAPEIQA ASMQVREVQA
     RFRRDVSHLS KNESLHHGSH QSISSIGRSY TNSFILDGVV DQKRWVYVPV RIVYTRSPNV
     KGTDPTLLGN SELQNDVCQT AHSGASKVFV ASDGLDYYGN YKEFAIIDER QPVSVTTTAV
     GIKNPEFGEG EVLFTSYDSC GRPCRPLCLT SVNGQQKYKA CSGAFKISSA APTLYRNSYK
     EAISVSLSSY NLVDSSLDDA SPPVTFVCGN DNAWPWVY
//