ID K1PTE7_CRAGI Unreviewed; 601 AA.
AC K1PTE7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN ORFNames=CGI_10007830 {ECO:0000313|EMBL:EKC19685.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC19685.1};
RN [1] {ECO:0000313|EMBL:EKC19685.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC19685.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; JH819072; EKC19685.1; -; Genomic_DNA.
DR AlphaFoldDB; K1PTE7; -.
DR HOGENOM; CLU_454363_0_0_1; -.
DR InParanoid; K1PTE7; -.
DR OMA; CINDYGR; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF41; UNC5C-LIKE PROTEIN; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 34..59
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
SQ SEQUENCE 601 AA; 68364 MW; 6FABF48453528957 CRC64;
MQVKLDPEVS MISNHVSKKE NTLKQTLKHD LLKIIGLAVL AVLVFLLIVA IILLTLFFLR
RLRRQSDKLS NIEKVLQEKD TPLRNLSSKT SDRPQTDSAV DVSELDNSFG PLDRNNTANP
KIISIRSTKS LSVITRRSVH CVTSEPNRPP PLPAQVVNLT QVTENNPKKE QTTADDIKFN
TSLSDEFMGV YESYFKQNVA QNRPTSVLCP ADSENETVQF ETGMFVHKEI DTSGGEMDIS
GVKLKIPKGA VEKKTRFTLG ITWDMDVFPD LTKREALLSP LVVCQPSMSF RKPVELNFPH
CADKIDVNWK WKIIKRGGDL TQQSSWDSIT LGDYDQRMVS KSSVTIHLHH FTLFALIGTS
KDDRVAAKAV QMVTFSSVLQ RTSLFTSKLY CINDYGRDIQ DIRRKEFEVN RKVIDSPVPL
LVYDNGENVV VKQTKEPEEW KLMGKKSMEL DFELVWHSCN PNCAFAYKPQ STDIGEIVVE
YTCHQTKHEE TKSSIQIVAE APKFLPAPFD KKQSEMTRNL IVCLDPATDN NSDWRGLAEK
MGMKFDKIRW IEEQSGSATE LLLKLWMDEG RPLEELRSLL LEMNRDDAVS VIDKYQKGDK
F
//
