ID   K1PXE6_CRAGI            Unreviewed;      1003 AA.
AC   K1PXE6;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Mitofusin-2 {ECO:0000313|EMBL:EKC26368.1};
GN   ORFNames=CGI_10025826 {ECO:0000313|EMBL:EKC26368.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC26368.1};
RN   [1] {ECO:0000313|EMBL:EKC26368.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC26368.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA   Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. ROCO subfamily. {ECO:0000256|ARBA:ARBA00008171}.
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DR   EMBL; JH817066; EKC26368.1; -; Genomic_DNA.
DR   RefSeq; XP_011437741.1; XM_011439439.2.
DR   AlphaFoldDB; K1PXE6; -.
DR   GeneID; 105335524; -.
DR   KEGG; crg:105335524; -.
DR   HOGENOM; CLU_011921_0_0_1; -.
DR   InParanoid; K1PXE6; -.
DR   OMA; SNTNTIC; -.
DR   OrthoDB; 2958146at2759; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   PANTHER; PTHR26392; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-RELATED; 1.
DR   PANTHER; PTHR26392:SF92; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
PE   3: Inferred from homology;
SQ   SEQUENCE   1003 AA;  115899 MW;  67B2A1525107AF80 CRC64;
     MEEDEIDRLR LPVARKRAKD ESIDISSLRN IGEIRCSLKR HLLRDRKTRD EVIRGLSSDA
     ENDTILRKIL GEIFTSTIQA LQDLRQSGDT LMGHLEQCFD NLSPRLVNEE SNLLSESIKC
     PIMVLGETGS GKSSFINLVL GCELLPHSLL SNTNTICEIQ YGENFKACFH LTGSSKEEHS
     FKSLEEMRQS LSNKIQKKGE QKSLYKRVEI FLPSDILKTG LLIVDSPGIA DTGEMTDIVL
     GYLIKACAFI YIINSENAGG VAPDRLQHLF KKVVEKVFRD EQDYRSTCAM FICNKWDQVP
     YEERSKVYQD TVKKLCSEST GWPNCTEDQI FRLSTKEAMF IQDTPERYIV GHFAAVLHKI
     NGLIPESRHI LLINSARFLQ QVLDKAAMFI ETSLSDVNLS QEERMIKNKE TLEDLTKLRK
     DVNEFFEKEK NNFNKGLEKI IRDLRDHLRS KETVSALCDF THSMDTAGVK WKEATIKVRI
     KLYDSITEEI QRWETQHKKL EILGSGMAKQ FQQKFPDFDS KLFNLQKRYI QHNKSGKMVA
     EDEEPFVPVI VAEKFDNINL GLKVLMGISI SPVLLIGAIV RLPVWGIKEL ARKVKGHMLE
     KEYDTDPKAS LRKYAESILE STSDPIKMKP IMENEVSPMF QYLENQRRRV LQQIEAELNL
     LDKRKEEKET REFIAKNCSS QKVRFERLRR RLTYFYKIEL MKSSYKKLSE FKLEETLYQG
     LFGEVCKVLP KAETDHHLEA VVVKNKHRID GVNIMEHMRV EEAYRSKRFV YNMPCISMML
     ESSSEHHFFW PVLSLPKCSF RSFVKSKLIN PEEKTQTLYT YIEPVISGLD FLHTKKLVHV
     DVSQDSVMVD QNDRVKLMHI TYPQKLDLSL FPEASTELEQ FVHFHWETMS ASSQREYSFQ
     HDMYGVGLMM WEIWTGQKAF QQVVTGLEPR TLLQFIRFLS TNKNSLRLGV EDGLGILAVN
     AWNDCIIKCQ NLSINAADLL NTLAPCKNST FDYSHAQAPL YSM
//