ID K1PZJ8_CRAGI Unreviewed; 1871 AA.
AC K1PZJ8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 6 {ECO:0000313|EMBL:EKC24504.1};
GN ORFNames=CGI_10012744 {ECO:0000313|EMBL:EKC24504.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC24504.1};
RN [1] {ECO:0000313|EMBL:EKC24504.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC24504.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; JH816628; EKC24504.1; -; Genomic_DNA.
DR HOGENOM; CLU_236423_0_0_1; -.
DR InParanoid; K1PZJ8; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00033; CCP; 2.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR InterPro; IPR024862; TRPV.
DR PANTHER; PTHR10582:SF2; INACTIVE; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00335; Tetraspanin; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00032; CCP; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF48652; Tetraspanin; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50923; SUSHI; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|EMBL:EKC24504.1};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 87..119
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 144..176
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1425..1482
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1483..1540
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
SQ SEQUENCE 1871 AA; 209135 MW; 8D48A3BF53C13061 CRC64;
MQAKFTGSTV WETRTDEQLL NEYKEDYFNK VVPHEACWDL NKRGGVGETP FQILYLVDSP
AHHAVGEILL RLYPKLSLDV YEGEEYFGES ALHIAIVFGC LDAVKLLIEK GAKIDQRSTG
RFFLPEDQKK GHTKTTNYEG YAYYGEYPIH FAAATGNQEI YDYLIDHGAN PNAQDTFGNT
ALHMVVICNQ VEMYKYIVRH HKLPAKTDIK NNVNLTPLTL ASKLGRHTIF KEMLELGSLE
LWRYSNITCS LYPLLALDSI GPTGDTNWNS ALMIIINGEN DDHLEMLEGG VMRQLLDEKW
KAFARRRFFV RLFLALIQLI LISVAVYLRP KTNLLAVNSY TDVIRFVCEI LTCIGCSITL
VADIFEIITQ GVFSFLKNCK NAPAQTLFMI SCTLFLACVP FRFLEMKQVE DVLMIIAVPC
AWLFLLFFAR TFKLTGPFVT MIYKMLLGDL LRFGIIYVIF LTGFTQAFYF LFRGNTSTQS
QGFDDIGDTV LTLFQMTLGE FKYQDFNYTK YSALTKIVFA IFMMLVPILL LNMLIAMMGN
TYQMVIAKSE KEWRKQWAKI VVVLERGFSR NQLLEFQKMY AIKMMGPPKE NLAEITEQVE
EQRGLMVIKT SSKTKARQRK GAISNWKLFG KEIIKQLKKH KNKGRKEPFK LGRIKRKRKP
SFNESDYSSD EDEKAKMFSK TLQQLAWERD IDLTKGKTFV TDPNLIEKLS PYIKKEDLSK
PPAAPNHHSP ANSNNNNSPT PNHVPNGVKH RGPGERTVKK PAGTPKAATT KQFSYNRVSP
LTLTKQPSPA EESGSDWEGS KPSRSVLKGM SVTDISLHGI DSAKSSYRKM FLEESRQTKD
IQKLPTEEVP NVAFKQGYAS SKSGSVKSDK SKSESEYKPS FYSKSEDGYT SQGSVESSRA
SRVSKSSSRT SRHSQRSTTT TTDETSTSTA TKSSKGGADC SLQEVDSETE DTSHISKISS
SRQETEHETS ESSAKPPRPS HTPEEEGSPK KHKHKRKKSK KSRHGSQASS STSLVNSMEN
EDHESELFGK EIIKQLKKHK NKGRKEPFKL GRIKRKRKPS FNESDYSSDE DEKAKMFSKT
LQQLAWERDI DLTKGKTFVT DPNLIEKLSP YIKKEDLSKP PAAPNHHSPA NSNNNNSPTP
NHVPNGVKHR GPGERTVKKP AGTPKAATTK QFSYNRVSPL TLTKQPSPAE ESGSDWEGSK
PSRSVLKGMS VTDISLHGID SAKSSYRKMF LEESRQTKDI QKLPTEEVPN VAFKQGYASS
KSGSVKSDKS KSESEYKPSF YSKSEDGYTS QGSVESSRAS RVSKSSSRTS RHSQRSTTTT
TDETSTSTAT KSSKGGADCS LQEVDSETED TSHISKISSS RQETEHETSE SSAKPPRPSH
TPEEEGSPKK HKHKRKKSKK SRHGSQASSS TSLVNSMENE DHENVTCNLE AYENTRVIIN
NTECNGNTTY ECEHGYYLVQ GNLQRTCLTG RTWSGIPPVC EQITCNLEVY ENTKVIINNT
IYNGITTYEC EHDYYLVQGN LQRTCLTGRT WSGIPPVCER CMCPCSMQNQ RFYNSSEELY
QRIQELRKIL KVEKNSTNAY LRKKISVPDS RPSSVGIGNI CGYGVIIVLI SDPLTVYKGS
VITDINNAIT ATGLGPEDYY GDGDLLLFLS GFLLVVFVAG LLVLVVALAG CCGGCCRNSA
ITKLYAAILI TFLIVEFILV IVIYGFSDSM MMGSIKKTLT SVVVSEYQGL VGNNTETFGW
NFIMTKYQCC GVYGYSDFTA TEVWKSSLVA GGTTYNLKIP IVCCDELPSS TDLNCTGTKT
GTNANKGCFE ELWKVSAGNL PIAVLALGLG LFLQVLLIVA ACDLSAKDKK GKVEPVVEVD
QTMKRGLPYK H
//
