ID   K1Q337_CRAGI            Unreviewed;       224 AA.
AC   K1Q337;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   08-NOV-2023, entry version 49.
DE   RecName: Full=Calcyclin-binding protein {ECO:0000256|ARBA:ARBA00015702};
GN   ORFNames=CGI_10011554 {ECO:0000313|EMBL:EKC28333.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC28333.1};
RN   [1] {ECO:0000313|EMBL:EKC28333.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC28333.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA   Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- FUNCTION: May be involved in calcium-dependent ubiquitination and
CC       subsequent proteasomal degradation of target proteins. Probably serves
CC       as a molecular bridge in ubiquitin E3 complexes. Participates in the
CC       ubiquitin-mediated degradation of beta-catenin (CTNNB1).
CC       {ECO:0000256|ARBA:ARBA00025145}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; JH823227; EKC28333.1; -; Genomic_DNA.
DR   RefSeq; XP_011422401.1; XM_011424099.2.
DR   AlphaFoldDB; K1Q337; -.
DR   HOGENOM; CLU_081441_2_0_1; -.
DR   InParanoid; K1Q337; -.
DR   OMA; WDVLTSI; -.
DR   OrthoDB; 616630at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044548; F:S100 protein binding; IEA:InterPro.
DR   GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   CDD; cd06468; p23_CacyBP; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   InterPro; IPR037201; CacyBP_N.
DR   InterPro; IPR037893; CS_CacyBP.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR007699; SGS_dom.
DR   InterPro; IPR015120; Siah-Interact_N.
DR   PANTHER; PTHR13164:SF3; CALCYCLIN-BINDING PROTEIN; 1.
DR   PANTHER; PTHR13164; CALICYLIN BINDING PROTEIN; 1.
DR   Pfam; PF04969; CS; 1.
DR   Pfam; PF09032; Siah-Interact_N; 1.
DR   SUPFAM; SSF140106; Calcyclin-binding protein-like; 1.
DR   SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR   PROSITE; PS51203; CS; 1.
DR   PROSITE; PS51048; SGS; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
SQ   SEQUENCE   224 AA;  26036 MW;  234245A7887693D8 CRC64;
     MDIGELRQDV EEMRDLLVKA TRSRVKDIIG VELRKLEHEV SRLEKAAADP VSSTEVPQKK
     PRPQIQTQTI TNYAWDQSDK FMKIYVTIKG VHSLPKERVT CEFGKRSFKL QVEEEENKRR
     SELYISTLLE DINPEESWYK LKTDTVLLML KKSTTGKTWP YVTSGEKAKK AKEDNEKKPK
     MDDDKDPNDS LMEMMKKMYD EGDDDMKRTI AQAWTQSKDK KGGP
//