ID K1Q4V0_CRAGI Unreviewed; 2160 AA.
AC K1Q4V0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Myosin-VIIa {ECO:0000313|EMBL:EKC28928.1};
GN ORFNames=CGI_10016431 {ECO:0000313|EMBL:EKC28928.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC28928.1};
RN [1] {ECO:0000313|EMBL:EKC28928.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC28928.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; JH816162; EKC28928.1; -; Genomic_DNA.
DR SMR; K1Q4V0; -.
DR HOGENOM; CLU_000192_14_1_1; -.
DR InParanoid; K1Q4V0; -.
DR OMA; GFQGRCR; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692:SF33; MYOSIN; 1.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REGION 614..636
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 156..163
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2160 AA; 249076 MW; FF1D4FD703D068F5 CRC64;
MVILSKGDHI WLETTSKGEF AVSIGARVKF HDKNRINVVD DDGKEHWIDL NRPMRHMHTT
SVEGVEDMIL LGDLNESGIL RNLFIRYMDN LIYTYTGSIL VAVNPYQILP IYTAEQIQLY
RDKKIGELPP HIFAIADNAY YSMQRYKHDQ CVIISGESGA GKTESTKLIL QFLAAVSGQH
SWIEQQILEA NPIMEAFGNA KTIRNDNSSR FGKYIDIHFN QKGSIEGAKI EQYLLEKSRI
VTQAHDERNY HIFYCMLAGM TNEEKQKLDV ADATKYWYLT QGGSITCEGR DDAKEFADIR
SAMKVLMFKD PEVWDILKIL AALLHVGNIK YNAIEMDNIE ASEVQDIQFI NKTARLFEVR
AQDLIDVLTT RTIVTRGESV TVTMGRDGAA DVRDAFVKGI YGRMFVWIVN KINLAIYKPS
STQLFRTSIG VLDIFGFESF DVNSFEQLCI NYANENLQQF FVQHIFKLEQ EEYDNEGINW
KHIEFVDNQD TLDLIGARPM NLISLVDEES VFPKGTDRSM LDKFNNNHRN NRNYLMPKSN
INLQFGLNHF AGVVFYDCKG FLEKNRDTFS PDLLGLIQTS SNKFLVHLFN NDINMGSDTK
KRAATLGSQF KKSLDLLMKT LSACQPFFVR CVKPNEYKKP LEFDRELCCK QLRYSGMMET
IRIRKAGYPI RHLFKDFVDR YRILAPGIGP SHKEDCRAAS NKICSVVFSG GDYQIGKSKV
FLKDAQDVYL EQCREKELAK KILILQKTIR AWHCRRRFLK MKDSCITMQT TWRAYIARKR
FLMIRQGYMR LQAIIRSRVL TARFNAVRSV MINLQRYCRG YLVRQWASKR MTSIVRLQAC
IRTMIARKKY RRQKIEFKKL QEAERLRMEE EQRLKRKMNE KKAKQEAERL YKERLAKMEH
EVNEEEIRQK SEILHKREQI DQAERKKNET VSDSKLVEEI FDIFDDDGNE PQGEGPYPFM
DLEEKRRRMI SENGLDLDEM AIPLPDDEED LSEYKFSKFA AMYFKNNATH SYIRRVLREP
LLPLASDGDK LAALAVWITI LRFMGDLPEP KYHTAMAEAK DTTPVMTKIY STLGRKFNKK
DLEEAQRMGL DIEKEPIPGI RGSGKRSVRK KLVSLTLKKK SKITEEVTRK LMQELDSSFS
SSGSNALLED RPSSNLEKLH FIIGHGILRP DLRDEIYCQI SKQLTQNPSK SSHARGWILL
SLCVGCFAPS DKFIKYLRNF IHEGPPGYAP YCEERLRRTF ANGTRNQPPS WLELQATKSK
KPLMLPITFM DGNTKTLLAD SATTARELCQ QLSEKIGLRD QFGFSLYIAL FDKVSSLGSG
GDHVMDAISQ CEQYAKEQGA QERNAPWRLF FRKEIFAPWH DPGEDLTATN LIYQQVVRGI
KFGEYRCDKE DDLGMIAAQQ YYIEHGSSPT PEKLQSLLPS YIPDYALNRQ NAVNFWHSTI
LSKIKTPYFT NDKVRAQKVK EDIVSYAKYK WPLLFSRFYE AYKFAGPSLP KNDVIIAVNW
TGVYVVDDQE QVLLELSFPE ITAVSSSRTG KMHGQSFTLA TVKGDEYTFT SPNAEDIRDL
VVTFLEGLKK RSKYVIALQD YSSPGEGSSF LSFNKGDLIV LDQQNGETVM NSGWCIGECI
RTKKKGDFPA ECVYVLPTIT KPPQEILNLF VQSTDQTLAP THQETAPDVT GEKMYTLEEY
SLDHFRPPPK RTLSKTLSTA RRRKPDELWR YSKEPLKQPL LKKLMGRDDL NHPSRRGRTA
NELTDQIFEP PLKTEILRDE IYCQIIKQLT DNRNDTSERR GWELMWLATG CFTPSTNLTR
EVLQFLRSRR NQISTDCVNR MQKTQKNGTR KYPPHQVEVE AIQHKTTQIL HKVYFPDDTD
EAFEVESSTR AKDFCHNIAN KLMLKSSEGF SLFVKIADKV ISVPEGDFFF DFVRHLTDWI
RKARPTRDGS VPSFTYQVFF MKKLWTNTVP GKDSYADQIF HYHQELPKLL RGYHKCGKEE
AAQLGALIYR VKCGDNKSGL TNIPRMLREL IPSDLVKASS PDDWKRQIIG YYNKNAGMSS
EEAKVEFLRI IYKWPTFGSA FFEVKQTTEP NYPEILLIAI NKHGVNLIHP STKEILATHP
FTKISNWSSG NTYFHMTIGN LVRGSKLLCE TSLGYKMDDL LTSYISLMLT SMNKQKSVKK
//
