ID   K1Q503_CRAGI            Unreviewed;       870 AA.
AC   K1Q503;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Neuronal acetylcholine receptor subunit alpha-9 {ECO:0000313|EMBL:EKC28968.1};
GN   ORFNames=CGI_10011842 {ECO:0000313|EMBL:EKC28968.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC28968.1};
RN   [1] {ECO:0000313|EMBL:EKC28968.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC28968.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA   Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; JH817687; EKC28968.1; -; Genomic_DNA.
DR   AlphaFoldDB; K1Q503; -.
DR   HOGENOM; CLU_329892_0_0_1; -.
DR   InParanoid; K1Q503; -.
DR   OMA; IENEEWA; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   CDD; cd18989; LGIC_ECD_cation; 2.
DR   CDD; cd19051; LGIC_TM_cation; 2.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 2.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   PANTHER; PTHR18945:SF865; ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 2.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 2.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000313|EMBL:EKC28968.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          31..229
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
FT   DOMAIN          464..667
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
SQ   SEQUENCE   870 AA;  98392 MW;  2C0F7057C27CB3C6 CRC64;
     MKQTLLLSAL CIFSSFVFVN GDVASDWIMF YRSIFNQYSK YSFPRVKQSH TVDVTLSYYL
     NGINNFDEVA GELKTVGFLK VEWKNELARW AEQPGGMSAA ITDTMIPISD LWFPPLALVN
     SVNSLAVLGS SEDLVAVQNT GENLWRPAVI LSSSCSTNPL YFPFDTQTCN LTFRAWDHIQ
     SEITLKATDT KVRLDFFSPS EQWELRDTEI ISWEREDISY LTFSLKLRRI PLWFVINMAA
     PIGLLGLLTT FVFLLPIEEG RVGYALGSFL TFSVYLSYII DSLPRTSDPM SYLTIYIVIQ
     VIMSGSVSCI SVFTVKLYMK DEEARIPNYM ALCIGFICCK FCSKDEEIEK EKTAAELEEK
     ENDNLGFSPD EENENQQNQE SSPQPEELPT SSKFGVPNIK WKPMDADGAE ICPDEDRIAF
     LNVEVPRVGW KMVAKTIDII FFLVPTCSIC QAIQKPNLGH VKLLFEDLFT HNNEYSNLVF
     PHEDQLATIK VNMKFALYSI PEFDEVGGTL SVIGRLKMAW FDNFVIEKYV PQRHVLEAIN
     IAQDDIWLPP ITVFNSVESL TPVGHSGYEV TVTLTNGYIQ WEIGVVTKTG CTVVATDYPF
     DTQYCTISFT PWGYSNSEVS IITDEENINL EDFIENEEWA VLESTQELSV AANRSIISYH
     LTLKRRPVFF IVNMMVPVIL LGMLNSLCFV LPIDSGERVG FATNVFLTFA VYLTILSSEL
     PVSSPLSIMS YYVAAMLSVS SVTTLIAIFT IQVSIYDPNE KIPTILVYIV AFITCRVCRK
     RYRRMGLRRH QTFEKTPLED DGRDPAAAGE VTDEDDDDED DIEKYRFGVS WLVVGKTLDK
     IFFLLFASGT LAVSGYFLVP LFMKLDTSIA
//