ID K1QC19_CRAGI Unreviewed; 460 AA.
AC K1QC19;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=alpha-L-fucosidase {ECO:0000256|ARBA:ARBA00012662};
DE EC=3.2.1.51 {ECO:0000256|ARBA:ARBA00012662};
GN ORFNames=CGI_10025762 {ECO:0000313|EMBL:EKC34402.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC34402.1};
RN [1] {ECO:0000313|EMBL:EKC34402.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC34402.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-
CC 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the
CC carbohydrate moieties of glycoproteins.
CC {ECO:0000256|ARBA:ARBA00004071}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 29 family.
CC {ECO:0000256|ARBA:ARBA00007951, ECO:0000256|PIRNR:PIRNR001092}.
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DR EMBL; JH819116; EKC34402.1; -; Genomic_DNA.
DR RefSeq; XP_011419621.1; XM_011421319.2.
DR AlphaFoldDB; K1QC19; -.
DR GeneID; 105322550; -.
DR KEGG; crg:105322550; -.
DR HOGENOM; CLU_002934_1_1_1; -.
DR InParanoid; K1QC19; -.
DR OMA; ADGFAMW; -.
DR OrthoDB; 2955544at2759; -.
DR GO; GO:0004560; F:alpha-L-fucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006004; P:fucose metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR016286; FUC_metazoa-typ.
DR InterPro; IPR031919; Fucosidase_C.
DR InterPro; IPR000933; Glyco_hydro_29.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10030; ALPHA-L-FUCOSIDASE; 1.
DR PANTHER; PTHR10030:SF46; ALPHA-L-FUCOSIDASE-RELATED; 1.
DR Pfam; PF01120; Alpha_L_fucos; 1.
DR Pfam; PF16757; Fucosidase_C; 1.
DR PIRSF; PIRSF001092; Alpha-L-fucosidase; 1.
DR PRINTS; PR00741; GLHYDRLASE29.
DR SMART; SM00812; Alpha_L_fucos; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001092};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001092};
KW Signal {ECO:0000256|PIRNR:PIRNR001092}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|PIRNR:PIRNR001092"
FT CHAIN 24..460
FT /note="alpha-L-fucosidase"
FT /evidence="ECO:0000256|PIRNR:PIRNR001092"
FT /id="PRO_5036530495"
FT DOMAIN 372..455
FT /note="Alpha-L-fucosidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16757"
SQ SEQUENCE 460 AA; 53808 MW; CA33F452505D846B CRC64;
MVMMKSVVLV LLLQIYIVCT VRYEPNWDSL DTRPLPEWYD KSKIGIFLHW GVFSVPAFKG
AWFWYEWKTQ KDKDVVKFME DNYPPDFTYA DFASQFHATF YNPDQWADLF EASGAKYVVL
VTKHHEGFTL WPSAASWNWN AYDVGPHRDL VGALADSIRN RTDIHFGVYH SLFEFYNPLY
LQDVANKHKT QDFVRNKALP ELYELVNRYK PDVVWSDGDW NENSTYWNST EFLAWLFNDS
PVKDTVVTND RWGKDANCKH GSFWNCQDKF KPGKIFKHKW ENCMTVDKKA WTHRRQIQIE
DVLTIEELLA EIAETVSYGG NILINVGPTA DGVIVPVFEE RLRQMGQWLK VNGEAIYETQ
PWFEGTDNIT FHGVWYTTKK QGNSTVVYGI VTMWPQDNRL LLGLPVTTAT TRVTMIGVKE
PLKWSLYKNI AMQIEFPLLP PNQMPCKWAW VIKMENLKNQ
//
