ID K1QCW7_CRAGI Unreviewed; 698 AA.
AC K1QCW7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Exostosin-2 {ECO:0000313|EMBL:EKC34747.1};
GN ORFNames=CGI_10021731 {ECO:0000313|EMBL:EKC34747.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC34747.1};
RN [1] {ECO:0000313|EMBL:EKC34747.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC34747.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH823219; EKC34747.1; -; Genomic_DNA.
DR RefSeq; XP_011422165.1; XM_011423863.2.
DR AlphaFoldDB; K1QCW7; -.
DR GeneID; 105324710; -.
DR KEGG; crg:105324710; -.
DR HOGENOM; CLU_013906_4_1_1; -.
DR InParanoid; K1QCW7; -.
DR OMA; NCTFWDC; -.
DR OrthoDB; 1220028at2759; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 86..361
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 436..681
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
SQ SEQUENCE 698 AA; 80488 MW; 3E860E57DFFC93ED CRC64;
MAVRLRVSLM LLFGLAGGIV TFYFIYHVNS AKSQEEDGRV RHSFKRSPGR ETVNLQNLDS
KPTPQNSKCT YHSCVDVFHC GYNDRTRISV YVYPVVEYID ENGSQASPVL SREFNEVLEA
ISDSPYYTNN PETACLFAPS FDVLNQNNVR TKALGKLYSL LQWWNDGANH LIFNMLPGEL
PDYKTTLEVD TGKAMIAGGG FSTWTYRRGF DVSIPVFNPF LENAYLQPKS NLESRKWLLV
SAQVGLHSEY KEVMFEVAAS EKRFLIMDKC TEGKNWDFKK RCQGTVEYTY PDILQDSKFC
MVLRSARLGH TALSDALRTG CIPVIVADGY VLPFSEVLDW KRAAVVIREE NLKDVVEVLK
SYSMERIYQM RRQARFFWEN YFHSIKAITE TTLQIINDRV FPYVAKKYEE WNEIPNPKAV
WNPMFLPLIP PSSQGFTAVV LTFNRPESLF QVISKLSLVQ SLSKIVVIWN NQAKPPPPMT
AWPLIPKPLK IIQTQKNKLS NRFFPYHEIQ TECILAIDDD ITMLTSDELE FGYQVWREFP
DRLVGFPSRV HLYGNESNKF KYESEWKNNI SMVLTGAAFH HKYYSYLYTY NMPGHIRQWV
DDNMNCEDIA MNFLISNVTG KGPIKVTPRK KFKCPECTNS EMLSSDTLHM VERSECVNNF
VRAYRSMPLK GVEFRADPVL YKDDVPNVVK MYTEVGSL
//
