ID K1QFC1_CRAGI Unreviewed; 761 AA.
AC K1QFC1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Sodium-and chloride-dependent GABA transporter ine {ECO:0000313|EMBL:EKC20246.1};
GN ORFNames=CGI_10006472 {ECO:0000313|EMBL:EKC20246.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC20246.1};
RN [1] {ECO:0000313|EMBL:EKC20246.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC20246.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JH816573; EKC20246.1; -; Genomic_DNA.
DR AlphaFoldDB; K1QFC1; -.
DR HOGENOM; CLU_366485_0_0_1; -.
DR InParanoid; K1QFC1; -.
DR OMA; WSSPMLL; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002925; Dienelactn_hydro.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR42948; TRANSPORTER; 1.
DR PANTHER; PTHR42948:SF1; TRANSPORTER; 1.
DR Pfam; PF01738; DLH; 1.
DR Pfam; PF00209; SNF; 2.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 30..227
FT /note="Dienelactone hydrolase"
FT /evidence="ECO:0000259|Pfam:PF01738"
SQ SEQUENCE 761 AA; 84710 MW; 83013AA2A3F2E1F6 CRC64;
MSGKKVTIKS ENPKGDLPCI VFNELLAESD KGLVVIQEWW GMNKQIKEEA HNISKMGKFV
SIVPDLYRGK IATDNEEAGH LMSNLDWQGA VKDIRASILH LKSMGCKKVG VTGFCMGGAL
SLAAGALLQG VVDAIAPFYG IPDEKLCDVS TIKCPVQCHF AALDHLVGFS SLKDAEKLEE
KLKAGNVDYE MNIYDGAAHA FTNATGPNYN KDSCHLALQR LCTFMNKSLE RVEERPHFRN
RLGLICSCLG SVVGTGNIWR FPRILASNSE EQGGLVFLIA WVLFLVLWSS PMLLIEYGTG
RYTRKAVIGS FRHIIGDGAT WCGAWITMVT FLISCYYSVV LGWCLYYFVY MIGHDLPETA
AEGEKIFQDF AEHSNWPILT HAIASSLAGL AVLRGVSTIE KTNMFLVPLL LVIILFTFVW
SLTRDYADVG IRFLFTPHWD SFGEPRLWVD ALSQNAFDTG AGMGLMIPYA SFMTINNNIV
KYGILIPSIN NLISLICGIM LFATVFSTMI ALEPTISKPG ILDIMKQAGP GSTGLTFIWI
PVLFSTIGTF GRILCVLFFA CLSIAGVTSL VANVEMVTHT LYDFGVPRKF GMPCTVLLLF
LGGLASALNL DVLTNQDFVW GFALVINGFM LQIMVVTYGS RKFREEMFNR YSLGDWRLPR
VWEWLVKIIA PLEALFIIGW WAYDLIDGEA GDEEKWYEFG RETLVITVVQ WGGLMVLLFS
INMIYLCCRR SEGEDTVRLL GQKDLETSAT EKVISYKDVQ L
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