ID K1QFE3_CRAGI Unreviewed; 1960 AA.
AC K1QFE3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Echinoderm microtubule-associated protein-like 6 {ECO:0000313|EMBL:EKC29849.1};
GN ORFNames=CGI_10026183 {ECO:0000313|EMBL:EKC29849.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC29849.1};
RN [1] {ECO:0000313|EMBL:EKC29849.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC29849.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR EMBL; JH817210; EKC29849.1; -; Genomic_DNA.
DR RefSeq; XP_011439843.1; XM_011441541.2.
DR HOGENOM; CLU_001930_0_0_1; -.
DR InParanoid; K1QFE3; -.
DR OMA; WIFGYSA; -.
DR OrthoDB; 2959353at2759; -.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF33; HELP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 12.
DR SMART; SM00320; WD40; 32.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR SUPFAM; SSF50960; TolB, C-terminal domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
FT DOMAIN 4..49
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT DOMAIN 381..461
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 661..709
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT DOMAIN 1342..1399
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
SQ SEQUENCE 1960 AA; 216254 MW; 8B6873676DBDB8D3 CRC64;
MATKTAPKSQ LRLEWVFGYR GHQCRNNLYY TASKEVTYFV AGVGIVYNPR EHKQRFFLGH
DDDILCLALH PDKTMVATGQ TGKNPFICVW DTTTMETVSI LQDGHQNGVA AVGFDKEGGR
VVSVGLDQHA TINVWDWRKG KILATVRGHS DRVFDVQFNP YAENSLVSCG VKHIKFWSLC
GNALTAKKGV FGKTGEIQTI MCLAFGPDDT TYSGTLAGDI YVWRGNNLDR VIPAAHQGAI
FTLDMSEDGY STGGKDGTVR LWDPDFKPVT SVNLSNSPVG YKGLSVRSVC WRGDRVLIGT
QDSQIFEVIV RDRDKPRCIV DGHAEGELWA LAVHPKKPIF ATGSDDQTLR LWNMNNFEAI
SKMSVDQKIR SCAFDADGSH IALGLTDGSF MVLKTRDLSE VIHLKDRKEV IHEMKFSPCG
KYLAVASNDN FVDIYSTEQR YKLLGTCRGS SSFITHIDWS TDSNYLQTNS GAAERLFFKM
PAGKQVTNRE EISSIHWYTF TGVLGNEVNG IWEKYTDTND VNAVDANFQG EVLVTGDDFG
LVKLFKFPCL KKGAKFRKYV GHSAHVTNVR FSHDKTRVIT TGGADHAVFQ WKFLADGSSE
PDPQSGFVDS NSEESDSDLS DVADMDSDLE AEKQVVYSRA IYKEDAAKIR KLNKEELQAG
QKRKRGPTAG LKLQFIHGYR GYDCRNNLFY TQNGEVVYHV AAAGIVYNRD KHSQKFYTEH
TDDILCLCIH PIKDLVATGQ VGRDPAVHVW DAETLKTASI LKGQHQRGVC AVDFSGDGKK
LASVGLDDNH CIVVWDWRKG EKLATTRGHK DKIFVIKWNP FEANKLITVG VKHIKFWTQA
GGGFTSTRGT FGNVSKSCDM LCVAFGRAAD ISFSGGSDGN VFIWKDSNLQ KSVKAHEGPL
FAMHSLDKGF VTGGKDGMIG LWDDQFERCL KQYYIKKSGI EQSSRGVLMT DLPPIRAIVL
GHGKILVGTK NGEVLEVDKG GPMTILAQGH MQGELWGLGM HPTKPICATV SDDKTLRVWD
LGTEHKMISY KILKQAGRSV GFSSDGKFLA VGQKDGSFMV VNGENMEEVI SFHHRKEEIS
DINFSPGEGK YLAVASHDNF VDIYNVLSKK RVGTCKAASS YITHVDWDGA GKLLMVNTGA
KEQLFYEAPR GKRLTLSNSE VEKLNWATWT CVLGKTCEGI WPPKSDITDV NATCLSKDRQ
LLATGDDFGF VKLFQYPVKG KFAKHKRYVG HSAHVTNVRW SADDKLLVST GGADTAVMVW
QCSSAADRNT TCGESDDSDT DSEEEGGYDS DVEREKNIDY NTKIYVNPIR EKEGTKPHLQ
EHAEVEKPSV SRNAPVPPKV QRVEIPSTGS KRKKITPVND LQLEYVHGYR GFDSRNNLHY
INDGADIVFH AAGAGIVQNL STGNQSFYLE HTDDIICLAV NQHSKFKNIV ASGQIGNPPS
IHVWDAVTKE TKSMLRGGHS RGVCSVDFSC TGKYIVSVDL ADDHQIAVWR WQDGVKVASA
PGHNQRIFRA EFRPDSDSQF VSVGVKHVKF WSVAGSELVG KRGILTDAGT GTKIKTLHTM
LSVAFGANNM TFTGAMNGDV YVWKDTTLTR LVPKAHNGPV FTMFTTLRDG FIVTGGKEGS
GKDNGPVKLW DQEMMRRRAF PLTETGNKID VVKSVCRAKG KILVGTKDNT VLEITEKNAA
VQVLVAGHGE GEVWGLDTHP LAAKFATSSY DGSVRIWDLA NKSLVGKLTV SAARSVAFSL
DGELIAVGCK NGEFLVFSAN DLKLLGKRRD RSGAINDIRF SPDKKHLAVG SEENCVDFYD
LSSGPALNRS GYCKGIPSFV IQMDFSADSR YIRVSTGAYI HQVFEVPSGK IIEDQKIIDN
ITWASWTSVL GKEVVGIWPK DSSNADVNCA HLSHLGTALA TGDDFGFVKL FDFPCSEVNA
PHKSFVGHSA HVTNVRFSFD DKYLISTGGD DCSIFVWRCL
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