ID K1QFX2_CRAGI Unreviewed; 2587 AA.
AC K1QFX2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Low-density lipoprotein receptor-related protein 1B {ECO:0000313|EMBL:EKC35782.1};
GN ORFNames=CGI_10018650 {ECO:0000313|EMBL:EKC35782.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC35782.1};
RN [1] {ECO:0000313|EMBL:EKC35782.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC35782.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH818918; EKC35782.1; -; Genomic_DNA.
DR HOGENOM; CLU_000085_2_1_1; -.
DR InParanoid; K1QFX2; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 17.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 17.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 6.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00057; Ldl_recept_a; 14.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR Pfam; PF00644; PARP; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00192; LDLa; 17.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 16.
DR SUPFAM; SSF63825; YWTD domain; 5.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 9.
DR PROSITE; PS50068; LDLRA_2; 17.
DR PROSITE; PS51120; LDLRB; 7.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:EKC35782.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EKC35782.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 838..883
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 884..926
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 976..1020
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1158..1201
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1463..1505
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1739..1783
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1784..1826
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 37..52
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 464..476
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 471..489
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 483..498
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 530..545
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 571..586
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 608..623
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 629..641
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 636..654
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 648..663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 690..705
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1960..1972
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1967..1985
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1979..1994
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2004..2022
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2016..2031
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2062..2077
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2108..2123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2127..2139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2134..2152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2212..2224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2219..2237
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2300..2318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2388..2398
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2587 AA; 292310 MW; AB4011E624777D88 CRC64;
MTSIQAPFET LSPYVSCNPN YERCPGEEVC IPLSKFCDKK KDCYLGGDEA SCNVTFRTLP
SCDTLNCEDN CTKTIKGPKC YCDSDKFTMV SEQNNTCIKY NPCDYHEGIC DQKCSFNNTT
NKVTCSCVSG YGSDGNQCFP LDGALTGKTY FWVAASKVLL QFRLDDVLNS TLRLAHSSPE
ANYIRTVDFD HRKQLVCWIM YRPSPIDKST MKCMNQTTQK IMEIPTEVSL ETIGSMAYDW
INENWYFLDV SNNRIILCNS EGQKCVRIVD FGNLVPQTLV LEPNLGLMFY TVKSKTMGWS
ICQAHLDGSN SSTLVDKIEE LFSPHGITID FANQQLYWVD HIKDTIERIN INGGAVNRNT
ITRLKTSINR GISILGNYIY VTSNDEDVKM SQIHRWNRSV SAVEYKHINL PDPYQLQIYH
PLRQPSYQLE EDQKSCKVRT ECSECKNGNC PNISYQECDI SSVCAVGFRR CPLSECLISS
WWCDTEPDCS DGADENFCDK KGKQRKRTCS EVTQFQCVRS GECIDREFQC NAVKDCEDGS
DEDGCEVYCS DMKTHYKCDS NSKCLLNSTI CDGKPDCLDG TDERNCEDCK GGFKCSESGE
CIPLRWKCDL EQDCEDGSDE YGCQPARNCT SDEFQCDGDS CILKSWRCDK EHDCKDGTDE
ANCTYSTCNF PNITCGPHDD VRCISPDKMC DGNDDCSDKS DENGCNPVNV SCRNHSCSDV
CRPAPPGLVK QLYICLCNES RDLSRDNRTC QPTNICQSWG ICQQTCEKLP QGHKCGCHEG
FHLEPDGFTC RPLDPEPEYL IFSNRHEMRS VDLSNHNYAA LVSGLHNTVA LDFYYNKSFI
FWTDVADDKI FRGKLQGNAL TDIEPIVDIG LATTEGLAVD WIGEKIYWVE SKLYQIEVAG
INGQNRTTLI AGNMVSPRAI VLDPRYGSLF WTDWDTKNPR IETCSMAGEN RHIIFHIRGI
VEGGWPNGLT VDYDFERLYW IDARSDSLHT ITYEGQDHRL VLLDKENIRH PFALTMFGSY
VYWTDWGINA IVSANKFDGS NVTVIKRTNT QPFDIQVYHP KRQLPWRNPC AVNNGNCSHL
CLISYNNTVG CVCPHLMELA ADGKTCKPDQ SFLVFVRRIE IRGVDLENAN FSVIPTLTTP
YVSKPVAVDY DISDEKEGYL FWADQDLKVI NRSPLSGLEV KTVIDAGRAL SLHAFAVDWI
SKNMYFSTYN EKTRRGSITV ANLDGAYRKE LYVRNETRVQ SITVSPVTGR LFFSVSNEDV
IYSAKMDGSG VQVIRSDANR PTNTNACKTK NGQCSQLCLP TGQNQRVCVC TAGYERKNET
YCAGINSLLI YSADSEIRGI TYNPNNSTQA LPFISQIQKA TVIDFHAAQD YIYWVETTPN
YRIVRIKRDL TGHEVILSDE QGRITDIAVD WIAGHLYWTD AQRKVIELIQ LEKKESEKER
KRYVVIHRDL LNPQNIVLSP KEGTMIWVDS GSMTIEQASL DGADRKVLLK LTTSNVSGLS
LDHTNRKMLY WCERESRSIR RLNIETKDLK TVSTAADCYS LTVFKTKMYW IDVPLSSSEA
SILSMSKEGG TPTVIQSKLP KNLISIKVFD REVQTDHDSY LLFSKVTAIQ SLHMTGNRNK
PAEEIQSKTQ IRNVIAIAAD YKQQRVFFSD IQQSNIQSVW INGSSFSNIT TVVPSIGSVE
GLAFDSVNST LYWTSYSNSS INRIKVNANT GEAAGKPQKL VQLSTSDHPR AIVVDSCTQR
MFWSNWHSSQ PGIQRAYFSG FSAQFIVKTD ISTPNGLAID HKEQFLYWID ARLDRIERCD
FDGNHRAVVM TSIPQHPFGL ALYEDYLYWT DWLLHAVVRV NKYDSSDYTY LEQNLNRQPM
GIAVFAEDAN DCTQNPCLNA GCTQQCHVVN KQAVCKCNDS FVLLPDGVRC ASETVRNCSN
LEFLCHDGSK CIPMVQTCNK INDCEDKSDE LDKVCNHTHC GTQFFTCANY QCIPWGKHCD
RQRDCLDGSD ERDCPCDKDS EFQCRNNQCI NKQHHCDQES DCDDHSDEVG CNVDCSLIYR
DDAYHWVSCN TTSTCIMQSW ICDGKPDCED NIDEKDCHPT NHSNNHCEEE GMFKCKKGDS
CIPMDWKCDF DNDCLDKSDE LNCDEKCEGG MTMCLDGTCI PQTWECDGHN DCINGTDEAL
DTCNHNRTCK STEFMCPSNF RCIPKVWLCD GDADCPKNED EDVAQGCQSL GCNKDEYQCH
NGLCIKSIFY CDSDNDCKDN SDEPPDCSRG CRPGEFKCTH HLNCINNSKL CDGFPDCYDH
SDEDAEKCAS KPPNNCQFRC GDGSCINESQ VCDGHDDCGD NTDEASNCNV NECTLMELDK
GKAIKNNGTY YKECQHDCTE KKIGYECVCN EGYELAPDKH SCTDVDECKT LYPCSHFCIN
TIGSYRCECA KGFHLVDGKN CQVTGSVKPY LILANGFYLR NISFLGHQSL VLNDLNNAVA
IDFDYQEEMI YWSEITNSMS KISRLNLTDH KVSSIAVVYG TGVYFAINAA YSARDTYSPR
DYNNYKRVYR CRVLTGDYCQ GAQDMKAPPN KSTRILFDSV VDNLINPGIF VIFNDTQAYP
EYLITFQ
//
