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Database: UniProt
Entry: K1QHC7_CRAGI
LinkDB: K1QHC7_CRAGI
Original site: K1QHC7_CRAGI 
ID   K1QHC7_CRAGI            Unreviewed;       466 AA.
AC   K1QHC7;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   11-DEC-2019, entry version 35.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 4 {ECO:0000313|EMBL:EKC36212.1};
GN   ORFNames=CGI_10024138 {ECO:0000313|EMBL:EKC36212.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Bivalvia; Pteriomorphia;
OC   Ostreoida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC36212.1};
RN   [1] {ECO:0000313|EMBL:EKC36212.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC36212.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W.H., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E.W., Wang H., Li N., Qian L., Zhang G.,
RA   Li Y., Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; JH817566; EKC36212.1; -; Genomic_DNA.
DR   RefSeq; XP_011444562.1; XM_011446260.2.
DR   RefSeq; XP_011444563.1; XM_011446261.2.
DR   RefSeq; XP_011444564.1; XM_011446262.2.
DR   EnsemblMetazoa; EKC36212; EKC36212; CGI_10024138.
DR   GeneID; 105340302; -.
DR   KEGG; crg:105340302; -.
DR   InParanoid; K1QHC7; -.
DR   KO; K05330; -.
DR   OMA; GHNRNGQ; -.
DR   OrthoDB; 956263at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434609,
KW   ECO:0000313|EMBL:EKC36212.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM        116..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        192..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          79..221
FT                   /note="IRK"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          228..400
FT                   /note="IRK_C"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
SQ   SEQUENCE   466 AA;  53412 MW;  CEDAB7BCBB8CE8CA CRC64;
     MQTVVMETGY GQISSETSTV LQQSDSPDLL DNGKHNMKTA SNDSFTEFMA RCAPTLSNGP
     TQGRRADRHY SKRMRRRLVY KNGEVNITQT NIRKRRRRFL ADIFTTLVDI KWRYNLLLFA
     LAFILSWLIF AVIWWLICFS HGDLEQQTMK NPQHVPCVKE MHSFTSALLF SIETQHTIGY
     GSRHTTEECP EAITVMMIQS CFGVICQAMM TGIVFAKLSR PKKRAETLMF SKNACICKQD
     GELCLLVRVG DMRKSHIVEA HVRAVVIKKK ITKEGEVLPL YQFDVNLGFE DGSDRLFLVW
     PVIISHRINE ESPFWEMSPE DLHREQFELI IILEGIVEST GMTTQARSSY LPGEILWGHR
     FERLVTFQKE NGQYQIDFSR FHNTMPVDTP QCSAKELAEM GDILQEHAYI DEDENTSLCS
     HKNDGFPSPY VIKRHGAAQT DFDDDLDSND SSIPSRIAVE ESETLL
//
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