ID K1QJ46_CRAGI Unreviewed; 612 AA.
AC K1QJ46;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit {ECO:0000256|ARBA:ARBA00031109};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN ORFNames=CGI_10020786 {ECO:0000313|EMBL:EKC31209.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC31209.1};
RN [1] {ECO:0000313|EMBL:EKC31209.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC31209.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
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DR EMBL; JH817310; EKC31209.1; -; Genomic_DNA.
DR AlphaFoldDB; K1QJ46; -.
DR HOGENOM; CLU_018822_0_2_1; -.
DR InParanoid; K1QJ46; -.
DR OMA; CLLQREY; -.
DR UniPathway; UPA00363; UER00861.
DR GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF47; METHYLCROTONOYL-COA CARBOXYLASE; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 4: Predicted;
SQ SEQUENCE 612 AA; 67321 MW; 8CC3637C42825989 CRC64;
MLKPICQLLY ARRLLQSLPI IETSSTRFIT TSNSTNNRTF KSSFRVIQDT SIDPVESERN
EKNYKQLLDQ YTKHVELAKS GGGEAAVQRH TLKQKKLLAS ERLRLLLDDE EDFLELGLSA
GLGMPYGDVP RAGMISGIGR IHGRLCMIIA NDATVKGGTI YPVALKKQLR VQEIAEQNRL
PTYYVVESGG GFLPLQAEIF LPGGRTFYNE AVMSSLGIPQ LAIVCGNCTA GGAYIPTMAE
EAVMIHKQGY IFLGGPPLVK AATGEVISAE DLGGATLHCS VSGCTDYFAE DEPEAFMIGR
NIAETLPSHN SCTLESEPPL YDANDIPGLI SPENNIDIYQ IISRIIDGSQ FSEFKKKFGP
TLVTGFGYIH GCLVGIVGNN GWLSEHAADK GAHFVQLCCE RNIPLIFLQN TQDNPDPPLS
GEMYGNQLRA HAKMISAVSC SCVPLITFII GNAIGPTSYV MANRSMSPNF LFCWPNAVFC
IDNPNKITQD LLQAGSSTGA DVEAVKVKVT QKMNTETTSF YAASRVWNDG IVLPQETRKV
VRQCLEVVNA YRQRDQPKAQ VVRQCLEVVN AYRQRDQPKA QVGMGDFWEH KNLIPEQLNT
SDICHRAKLQ SE
//
