ID K1QJV3_CRAGI Unreviewed; 884 AA.
AC K1QJV3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
DE AltName: Full=Beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00030512};
DE AltName: Full=N-acetyl-beta-glucosaminidase {ECO:0000256|ARBA:ARBA00033000};
GN ORFNames=CGI_10002999 {ECO:0000313|EMBL:EKC21981.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC21981.1};
RN [1] {ECO:0000313|EMBL:EKC21981.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC21981.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; JH815813; EKC21981.1; -; Genomic_DNA.
DR AlphaFoldDB; K1QJV3; -.
DR HOGENOM; CLU_007082_4_1_1; -.
DR InParanoid; K1QJV3; -.
DR OMA; SANCEIP; -.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd02847; E_set_Chitobiase_C; 1.
DR Gene3D; 2.60.40.290; -; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR008965; CBM2/CBM3_carb-bd_dom_sf.
DR InterPro; IPR012291; CBM2_carb-bd_dom_sf.
DR InterPro; IPR004866; CHB/HEX_N_dom.
DR InterPro; IPR004867; CHB_C_dom.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF03173; CHB_HEX; 1.
DR Pfam; PF03174; CHB_HEX_C; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SMART; SM01081; CHB_HEX; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR SUPFAM; SSF49384; Carbohydrate-binding domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 67..225
FT /note="Chitobiase/beta-hexosaminidases N-terminal"
FT /evidence="ECO:0000259|SMART:SM01081"
FT ACT_SITE 572
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 884 AA; 101165 MW; 996170F5BFFF2B11 CRC64;
MPLTSLHFNH SLQFCESFLI EEFKFPVPPT KTSPQEKGKF SPEEIEVKRK KSLSKQESQV
YVNYMADNFV INFTVIQNSA RTCIKKFSIY NAGQRNIPSF FWAIYFYDNG KVGHNSFPYP
RGLPVDNSEL LIFHEAGNLY RLSPTEKFSP YINSRDTIEV PYESYGPHVS RHYSFPNWFV
SCDICSPRVL KSTAGEDLSF VETFSKPQQL KRNSRDLYRA FTAKDRFSRN SAAAKAPKPS
VHSVIPTPLR VDAGGEESLV VTPSDWVVST KDFVEEASLL AEKLHLKIAK SATSKVITFS
QGKVTLPKNS SLSISEAYHI YINPSKNTIE VTANEASGAF YAAQTLLSLT EKDRSDSSKE
KGHRFPGMNI TDAPRFEYRG LMLDVSRNFV QKATVLKLLD LMATYKVNKF HFHLTDDDAW
RLEIPEFPEL TKYASNRCLD PSHEVCLPPS LGSGPFVNTS GSGFYTVNDY KEILRYAKSR
HIEVIPEIDV PGHARSAIQA MELRYRRTKN SMYRLIDPDD RSRYLSAQSY TDDAVNPCVD
GTYQFFKVIL RNLQELHKDI QPLTFYMLGG DEVAGGAWEK SPACADLKQK HELRDYHDLK
KFFFKRMMEE LRQEDLTFGL WGDAVLDKSL NPNPLEEGTK GKVYTYSWSN VWEWKRGSLA
YKLANAGYKP YEPDFEERGL YWATRCLDSR TAFSFVPDHL YWNRGRTQDG GEMTDEILCT
GGCPPLTQPQ NIRGIQADLW TETIRTPQHL HYMLFPRFLA FAERAWHKAS WEDLTDVAQR
DKEQQKDWER FAAIVGKEEL ERLESEGVEY RLDPPGARFS NSILEINTIF PGLPTEYSLN
QGASWEKYNP KITTNLSNAG KILVRSSSFD GKRKSRVVSV ENSN
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