ID K1QS00_CRAGI Unreviewed; 1493 AA.
AC K1QS00;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=CGI_10021030 {ECO:0000313|EMBL:EKC33959.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC33959.1};
RN [1] {ECO:0000313|EMBL:EKC33959.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC33959.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; JH816631; EKC33959.1; -; Genomic_DNA.
DR HOGENOM; CLU_249048_0_0_1; -.
DR InParanoid; K1QS00; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd08215; STKc_Nek; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR44535; PROTEIN CBG16200; 1.
DR PANTHER; PTHR44535:SF4; SERINE_THREONINE-PROTEIN KINASE NEK8; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00415; RCC1; 5.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50012; RCC1_3; 5.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EKC33959.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EKC33959.1}.
FT DOMAIN 240..498
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 1493 AA; 165039 MW; 401192FCE665AC45 CRC64;
MAQKEDGSHH ASYDDLHMIH DLPPHERSPT RRETKSLHDL HLAVQNSEDK RVTEFLTSDE
SQIRPPSKGK TTKTDNVADS EFESTGVPLQ IQDEAAVLGD VGGGHSNDSS QTEVGESPRL
LLVSTKIRNS IYFRHSIKPS VIFVQYKYDS MTTDGILALV NQTLNERKVD SIALMMSCCG
PNIQISGKDD KVKVTMSRDI AGNDSKQSSS ENKINVGKLY FRMEKLRGLS GNNQQSLAGF
EKIQTVGKGA YGAAVLYRKK DDDSLVILKE INMHDLNAAE RQLALNEVSI LAMLDHPNII
SYYDSFEEDG VLMIEIEYAD GGTLAQKLAA MATKDKNIEE KEVLQIFQQI VAAIRHIHEL
NILHRDLKTA NIFLTKEGVV KVGDFGISKM LSSANKGANT VLGTPYYISP EMCEGKPYND
KSDIWALGCI LYEMACLQKT FEGSNLPALV NKIMKGQFAP VKGNYSEEFK SLIMDMLKQD
PDERPSANEI MYTRLPELLN RFEDPDTDEE LSLSQGNVND PKSKKKLRSV FFYFESCTAS
MTPIELPPKI KIRHAAVGED HVIVVTTEKQ VYSWGSGDKG QLGHGNMESK MKPELVQSLN
GKSISRACCG EGFSIFASDN GIVLTCGDGT SGCLGHGDTL SCYRPRLIET LLSLDVIAIS
CGSKHVVVVG SEGEVLTWGC GADGRLGLGT EDNHCQPQEL RIEEPVVIRD VFCGVDGTMF
LTDVGSVYAC GSNSDNKLGL NNRQGFIMAM KNIFTKTEVE GSNVPTPVRA LARHRVLGIS
MGACHTAVIV EPGHIYTFGK NSEGQLGIGD TKPSRAPVEV KAMLESVRVQ CGNHYTVCST
TSNELYYWGL RNKTPVQTYL QDNDSKSSTT DSFVNNNDLR LESVTPRSGT TKASHSRQPS
LTSVTSATSN RDSMHGSQSS VQGEIEREAV TLMKSPAHRR QTSIDSVASI ASLTDSGLPS
STANTPQETT PQGPMGFRPL SSVRKRTPSE GSLKPESEHG PPDNSEIIFP PMHLMKILKS
GDEMLTISGF FCHGENLFIQ METTAPPPRR KKRKKIGIRK RFSGNTLNVP AETQALYTAS
SREGGDEYSS EASEIDTQGT VPAWIKNELR FSGQESKDDG NEADDTSDQS DDTLHRRVVD
SSMSNIQINK NLAPNPGIIE ISPRDKKKEQ TNEPSATNTS KLVKVQDFSR RSISTNSTES
EIDCSTDNGS KKVPAWIKNE LRFSGQESKD DGNEADDTSD QSDDTLHRRV VDSSMSNIQI
NKNLAPNPGI IEISPRDKKK EQTNEPSSTN TSKLVKVQDF SRRSISTNST ESEIDCSTDN
GSKKVGDSVG LRKSSQPTAK KPPQNRLPPG PQRPVIRGKG QTRTRGNDLS WKEKLAARGF
VSDVTVKRKQ EALQNELEIT REEKKKAEEK LREMEEEHKY QREMEKRELE RRAQEREKNL
EAQIQMLKQQ LESHCSQLQD NQKLLTSLQS ELTKVKGRNH SNPDKDSRVC AVM
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